KEGG   ENZYME: 1.2.1.98
Entry
EC 1.2.1.98                 Enzyme                                 
Name
2-hydroxy-2-methylpropanal dehydrogenase;
mpdC (gene name)
Class
Oxidoreductases;
Acting on the aldehyde or oxo group of donors;
With NAD+ or NADP+ as acceptor
Sysname
2-hydroxy-2-methylpropanal:NAD+ oxidoreductase
Reaction(IUBMB)
2-hydroxy-2-methylpropanal + NAD+ + H2O = 2-hydroxy-2-methylpropanoate + NADH + H+ [RN:R11350]
Reaction(KEGG)
R11350
Substrate
2-hydroxy-2-methylpropanal [CPD:C21291];
NAD+ [CPD:C00003];
H2O [CPD:C00001]
Product
2-hydroxy-2-methylpropanoate [CPD:C21297];
NADH [CPD:C00004];
H+ [CPD:C00080]
Comment
This bacterial enzyme is involved in the degradation pathways of the alkene 2-methylpropene and the fuel additive tert-butyl methyl ether (MTBE), a widely occurring groundwater contaminant.
History
EC 1.2.1.98 created 2016
Orthology
K20928  2-hydroxy-2-methylpropanal dehydrogenase
Genes
MVQ: MYVA_3537
PSEA: WY02_10405
PSEE: FRP1_03820
PSEQ: AD006_11480
PECQ: AD017_19310
PHH: AFB00_04325
RRD: RradSPS_2606
RMAR: GBA65_01870
Reference
1  [PMID:16622053]
  Authors
Lopes Ferreira N, Labbe D, Monot F, Fayolle-Guichard F, Greer CW
  Title
Genes involved in the methyl tert-butyl ether (MTBE) metabolic pathway of Mycobacterium austroafricanum IFP 2012.
  Journal
Microbiology 152:1361-74 (2006)
DOI:10.1099/mic.0.28585-0
  Sequence
[ag:AAZ78235]
Other DBs
ExplorEnz - The Enzyme Database: 1.2.1.98
IUBMB Enzyme Nomenclature: 1.2.1.98
ExPASy - ENZYME nomenclature database: 1.2.1.98
BRENDA, the Enzyme Database: 1.2.1.98

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Chemical substance (6)   
   KEGG COMPOUND (6)   
Chemical reaction (2)   
   KEGG REACTION (1)   
   KEGG RCLASS (1)   
Gene (10)   
   KEGG ORTHOLOGY (1)   
   KEGG GENES (9)   
Protein sequence (5)   
   UniProt (4)   
   SWISS-PROT (1)   
DNA sequence (4)   
   GenBank (2)   
   EMBL (2)   
Protein domain (5)   
   InterPro (5)   
All databases (32)   

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