KEGG   ENZYME: 1.2.5.2
Entry
EC 1.2.5.2                  Enzyme                                 
Name
aldehyde dehydrogenase (quinone);
aldehyde dehydrogenase (acceptor)
Class
Oxidoreductases;
Acting on the aldehyde or oxo group of donors;
With a quinone or similar compound as acceptor
Sysname
aldehyde:quinone oxidoreductase
Reaction(IUBMB)
an aldehyde + a quinone + H2O = a carboxylate + a quinol [RN:R10911]
Reaction(KEGG)
R10911 > R01019 R03535 R10912
Substrate
aldehyde [CPD:C00071];
quinone [CPD:C15602];
H2O [CPD:C00001]
Product
carboxylate [CPD:C00060];
quinol [CPD:C15603]
Comment
Wide specificity; acts on straight-chain aldehydes up to C10, aromatic aldehydes, glyoxylate and glyceraldehyde. The enzymes contains a PQQ cofactor and multiple hemes that deliver the electrons to the membrane quinone pool.
History
EC 1.2.5.2 created 1983 as EC 1.2.99.3, modified 1989, transferred 2015 to EC 1.2.5.2
Pathway
ec00071  Fatty acid degradation
ec00620  Pyruvate metabolism
Reference
1
  Authors
Ameyama, M. and Adachi, O.
  Title
Aldehyde dehydrogenase from acetic acid bacteria, membrane-bound.
  Journal
Methods Enzymol 89:491-497 (1982)
Reference
2
  Authors
Ameyama, M., Osada, K., Shinagawa, E., Matsushita, K. and Adachi, O.
  Title
Purification and characterization of aldehyde dehydrogenase of Acetobacter aceti.
  Journal
Agric Biol Chem 45:1189-1890 (1981)
Reference
3  [PMID:6779711]
  Authors
Patel RN, Hou CT, Derelanko P, Felix A.
  Title
Purification and properties of a heme-containing aldehyde dehydrogenase from Methylosinus trichosporium.
  Journal
Arch Biochem Biophys 203:654-62 (1980)
DOI:10.1016/0003-9861(80)90223-4
Reference
4  [PMID:20802042]
  Authors
Gomez-Manzo S, Chavez-Pacheco JL, Contreras-Zentella M, Sosa-Torres ME, Arreguin-Espinosa R, Perez de la Mora M, Membrillo-Hernandez J, Escamilla JE
  Title
Molecular and catalytic properties of the aldehyde dehydrogenase of Gluconacetobacter diazotrophicus, a quinoheme protein containing pyrroloquinoline quinone, cytochrome b, and cytochrome c.
  Journal
J Bacteriol 192:5718-24 (2010)
DOI:10.1128/JB.00589-10
Other DBs
ExplorEnz - The Enzyme Database: 1.2.5.2
IUBMB Enzyme Nomenclature: 1.2.5.2
ExPASy - ENZYME nomenclature database: 1.2.5.2
BRENDA, the Enzyme Database: 1.2.5.2
CAS: 75536-77-5

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Pathway (4)   
   KEGG PATHWAY (4)   
Chemical substance (12)   
   KEGG COMPOUND (12)   
Chemical reaction (7)   
   KEGG REACTION (4)   
   KEGG RCLASS (3)   
Protein sequence (171)   
   UniProt (162)   
   SWISS-PROT (4)   
   RefSeq(pep) (5)   
DNA sequence (220)   
   RefSeq(nuc) (3)   
   GenBank (125)   
   EMBL (92)   
Protein domain (8)   
   InterPro (8)   
All databases (422)   

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