KEGG ENZYME: 1.2.98.1

ENZYME: 1.2.98.1

Entry

EC 1.2.98.1                 Enzyme

Name

formaldehyde dismutase;
aldehyde dismutase;
cannizzanase;
nicotinoprotein aldehyde dismutase

Class

Oxidoreductases;
Acting on the aldehyde or oxo group of donors;
With other, known, physiological acceptors

Sysname

formaldehyde:formaldehyde oxidoreductase

Reaction(IUBMB)

2 formaldehyde + H2O = formate + methanol [RN:R00614]

Reaction(KEGG)

R00614

Substrate

formaldehyde [CPD:C00067];
H2O [CPD:C00001]

Product

formate [CPD:C00058];
methanol [CPD:C00132]

Comment

The enzyme contains a tightly but noncovalently bound NADP(H) cofactor, as well as Zn2+ and Mg2+. Enzyme-bound NADPH formed by oxidation of formaldehyde to formate is oxidized back to NADP+ by reaction with a second formaldehyde, yielding methanol. The enzyme from the bacterium Mycobacterium sp. DSM 3803 also catalyses the reactions of EC 1.1.99.36, alcohol dehydrogenase (nicotinoprotein) and EC 1.1.99.37, methanol dehydrogenase (nicotinoprotein) [3]. Formaldehyde and acetaldehyde can act as donors; formaldehyde, acetaldehyde and propanal can act as acceptors [1,2].

History

EC 1.2.98.1 created 1986 as EC 1.2.99.4, modified 2012, transferred 2015 to EC 1.2.98.1

Pathway

ec00625

Chloroalkane and chloroalkene degradation

ec00680

Methane metabolism

ec01100

Metabolic pathways

ec01120

Microbial metabolism in diverse environments

Orthology

K17067

formaldehyde dismutase / methanol dehydrogenase

K17068

formaldehyde dismutase

Genes

PASI:

LG197_22300

DEX:	HWD60_01710(mdo)

DVN:	HQ394_08800(mdo)

GPI:	GPICK_06680

GEB:

GM18_3226

GUR:

Gura_3568

GHC:	L9S41_14580

AORY:

AMOR_45610

DAE:

Dtox_4270

MDX:	BTO20_03135 BTO20_38200

MADI:

A7U43_05480

MSM:	MSMEG_6242

MSG:	MSMEI_6081

MSB:	LJ00_30865

MSN:	LI99_30870

MSH:	LI98_30875

MVA:

Mvan_5479

MCB:	Mycch_5913

MNE:	D174_25530

MYN:	MyAD_25070

MLL:	B1R94_22390

MRH:	MycrhN_3030

MAUU:

NCTC10437_05223(thcE)

MTY:	MTOK_19990

MPSC:

MPSYJ_14360

MANY:

MANY_50600

MPOF:

MPOR_01100

MMAT:

MMAGJ_31270

MGO:	AFA91_03425

MRF:	MJO55_25005(mdo)

ASD:

AS9A_4308

NFA:

NFA_22240

NFR:	ERS450000_01873(thcE)

RHA:	RHA1_ro06057

RER:

RER_17770

REY:

O5Y_08520

REB:	XU06_08765

RQI:	C1M55_08995(mdo)

ROP:

ROP_61160

ROA:	Pd630_LPD02697

RPY:	Y013_08845

RBY:	CEJ39_19735(mdo)

RHB:

NY08_1972

RAV:	AAT18_18670

RFA:	A3L23_00307

RHS:	A3Q41_03101

RRZ:	CS378_08140(mdo)

RHU:	A3Q40_00401

RHQ:	IM25_00685

RHOD:

AOT96_19365

RRT:	4535765_03582(thcE)

RKO:	JWS14_33040(mdo)

RGO:	KYT97_09645(mdo)

ROZ:	CBI38_20475

RPSK:

JWS13_10915(mdo)

RGOR:

NMQ04_15600(mdo)

RANT:

RHODO2019_14350(mdo)

RHOP:

D8W71_01660(mdo)

PDEF:

P9209_16105(mdo)

GBR:

Gbro_1931

GPO:	GPOL_c18220 GPOL_c38190

GOR:

KTR9_1872

GOQ:	ACH46_07270

GTA:	BCM27_10050

GOC:	CXX93_15365(mdo)

GIT:	C6V83_07720(mdo)

GRU:	GCWB2_09440(thcE)

GOM:	D7316_01326(mno) D7316_03687(thcE)

GAV:	C5O27_18320(mdo)

GOD:	GKZ92_09040(mdo)

GAM:	GII34_08675(mdo)

GPD:	GII33_01450(mdo) GII33_08060(mdo)

GJI:	H1R19_09330(mdo)

GOI:	LK459_01040(mdo) LK459_01660(mdo)

GHN:	MVF96_09455(mdo)

GAMI:

IHQ52_12330(mdo)

GMG:	NWF22_19715(mdo)

GSI:	P5P27_05920(mdo)

TSM:	ASU32_17935

TSD:	MTP03_02780

DTM:	BJL86_1140

DIZ:	CT688_01100(mdo)

DPC:	A6048_01130

DKN:	NHB83_01010(mdo)

TOY:	FO059_05730(mdo)

SHY:

SHJG_2446

SHO:	SHJGH_2211

STUI:

GCM10017668_53940

SANT:

QR300_11405(mdo)

ALX:	LVQ62_05600(mdo)

BEI:	GCM100_01200

JAY:	H7A72_14585(mdo)

PHW:	G7075_01320(mdo)

NARO:

CFH99_06345(mdo)

NAQU:

ENKNEFLB_00974(mno)

NRO:	K8W59_04780(mdo)

NPC:	KUV85_09765(mdo)

NPS:	KRR39_16410(mdo)

NML:

Namu_0777

SEN:

SACE_2386

SACG:

FDZ84_34730(mdo)

AMQ:	AMETH_5577(mdo)

PSEA:

WY02_13685

PSEE:

FRP1_00395 FRP1_00630

PSEH:

XF36_28100

PSEQ:

AD006_08035 AD006_08270

PECQ:

AD017_15870 AD017_16100

PHH:	AFB00_08750 AFB00_13725

PAUT:

Pdca_61440 Pdca_62050

PBRO:

HOP40_10780(mdo)

PPEL:

H6H00_10950(mdo)

ACTY:

OG774_15480(mdo)

RRD:	RradSPS_2629

RUB:	GBA63_20895

RMAR:

GBA65_20385(mdo)

» show all

Reference

Authors

Kato, N., Shirakawa, K., Kobayashi, H. and Sakazawa, C.

Title

The dismutation of aldehydes by a bacterial enzyme.

Journal

Agric Biol Chem 47:39-46 (1983)

Reference

2 [PMID:3514215]

Authors

Kato N, Yamagami T, Shimao M, Sakazawa C

Title

Formaldehyde dismutase, a novel NAD-binding oxidoreductase from Pseudomonas putida F61.

Journal

Eur J Biochem 156:59-64 (1986)
DOI:10.1111/j.1432-1033.1986.tb09548.x

Sequence

[ag:AAA25818]

Reference

3 [PMID:19875438]

Authors

Park H, Lee H, Ro YT, Kim YM

Title

Identification and functional characterization of a gene for the methanol : N,N'-dimethyl-4-nitrosoaniline oxidoreductase from Mycobacterium sp. strain JC1 (DSM 3803).

Journal

Microbiology 156:463-71 (2010)
DOI:10.1099/mic.0.034124-0

Sequence

[ag:ACS29499]

Other DBs

ExplorEnz - The Enzyme Database:

1.2.98.1

IUBMB Enzyme Nomenclature:

1.2.98.1

ExPASy - ENZYME nomenclature database:

1.2.98.1

BRENDA, the Enzyme Database:

1.2.98.1

CAS:	85204-94-0

DBGET integrated database retrieval system