KEGG ENZYME: 1.2.99.10

ENZYME: 1.2.99.10

Entry

EC 1.2.99.10                Enzyme

Name

4,4'-diapolycopenoate synthase;
crtNc;
4,4'-diapolycopenealdehyde oxidase (misleading)

Class

Oxidoreductases;
Acting on the aldehyde or oxo group of donors;
With unknown physiological acceptors

Sysname

4,4'-diapolycopen-4-al,donor:oxygen oxidoreductase (4,4'-diapolycopen-4-oate-forming)

Reaction(IUBMB)

(1) 4,4'-diapolycopen-4-al + H2O + acceptor = 4,4'-diapolycopen-4-oate + reduced acceptor [RN:R11913];
(2) 4,4'-diapolycopene-4,4'-dial + 2 H2O + 2 acceptor = 4,4'-diapolycopene-4,4'-dioate + 2 reduced acceptor [RN:R11914]

Reaction(KEGG)

R11913 R11914

Substrate

4,4'-diapolycopen-4-al [CPD:C21766];
H2O [CPD:C00001];
acceptor [CPD:C00028];
4,4'-diapolycopene-4,4'-dial [CPD:C19798]

Product

4,4'-diapolycopen-4-oate [CPD:C21768];
reduced acceptor [CPD:C00030];
4,4'-diapolycopene-4,4'-dioate [CPD:C21770]

Comment

The enzyme has been described from the bacteria Methylomonas sp. 16a and Bacillus indicus.

History

EC 1.2.99.10 created 2017

Pathway

ec00906

Carotenoid biosynthesis

ec01110

Biosynthesis of secondary metabolites

Orthology

K22445

4,4'-diapolycopenoate synthase

K25072

4,4'-diapolycopenoate synthase

Genes

MMT:	Metme_3773

MDN:	JT25_002370

MDH:	AYM39_15935

MKO:	MKLM6_3291

METL:

U737_16975

MPAD:

KEF85_14160

MELL:

IVG45_20690

MRP:	NM686_003120

MPSY:

CEK71_14810

SDO:	SD1155_11615

NTX:	NQZ71_05585

LYP:	MTP04_10760

LLB:	R6U77_01040

PSYB:

KD050_16600

DOM:	RRU94_17435

SAU:	SA1736(aldH)

SAV:	SAV1920(aldH)

SAW:	SAHV_1905(aldH)

SAH:	SaurJH1_2010

SAJ:	SaurJH9_1977

SAM:	MW1861(aldH)

SAS:

SAS1844

SAR:

SAR2013

SAC:	SACOL1984(aldA2)

SAX:	USA300HOU_1923(aldH1)

SAA:	SAUSA300_1901(aldA2)

SAO:	SAOUHSC_02142

SAE:

NWMN_1858

SAD:	SAAV_1988(aldA2)

SUU:	M013TW_1958

SUV:	SAVC_08865

SUE:

SAOV_2023

SUJ:	SAA6159_01852

SUK:	SAA6008_01942(aldH)

SUC:	ECTR2_1793

SUT:	SAT0131_02050

SUQ:	HMPREF0772_11220

SUZ:

MS7_1956

SUD:	ST398NM01_2015

SUX:	SAEMRSA15_18300

SUW:	SATW20_19150

SUG:

SAPIG2015

SUF:	SARLGA251_18050

SAUA:

SAAG_02441

SAUE:

RSAU_001807(aldA)

SAUN:

SAKOR_01884

SAUS:

SA40_1762

SAUU:

SA957_1846

SAUG:

SA268_1918

SAUZ:

SAZ172_1934

SAUT:

SAI1T1_2014580(aldH)

SAUJ:

SAI2T2_1014590(aldH)

SAUK:

SAI3T3_1014580(aldH)

SAUQ:

SAI4T8_1014590(aldH)

SAUV:

SAI7S6_1014590(aldH)

SAUW:

SAI5S5_1014530(aldH)

SAUX:

SAI6T6_1014550(aldH)

SAUY:

SAI8T7_1014570(aldH)

SAUF:

X998_1976

SAB:

SAB1857

SUY:	SA2981_1878(aldH)

SAUB:

C248_1998

SAUM:

BN843_19610

SAUC:

CA347_2010

SAUR:

SABB_02345(aldH)

SAUI:

AZ30_10235

SAUD:

CH52_09320

SUH:	SAMSHR1132_17650

SER:	SERP1456(aldA-1)

SEP:

SE_1603

SEPP:

SEB_01590

SEPS:

DP17_549

SHA:	SH1033(aldH)

SHH:	ShL2_00921(aldH)

SSP:

SSP0871

SCA:	SCA_1490(aldH)

SLG:	SLGD_01007

SLN:	SLUG_10460

SSD:	SPSINT_1673

SDT:	SPSE_0822(aldA2)

SDP:	NCTC12225_00891(aldA2)

SWA:	A284_04405

SPAS:

STP1_0437

SXY:	BE24_07515

SXL:	SXYLSMQ121_0908

SXO:	SXYL_00917

SHU:	SHYC_04225

SCAP:

AYP1020_1196(alkH)

SSCH:

LH95_04115

SSCZ:

RN70_04335

SAGQ:

EP23_05765

SEQO:

SE1039_17070

SSIF:

AL483_02355

SCV:	A4G25_12615

SPET:

CEP67_04025

SLZ:	B5P37_02055

SCOH:

BZ166_08815

SNL:	BJD96_04780

SKL:	C7J89_05895

SFQ:	C7J90_11540

SHOM:

EGX58_08535

SMUS:

C7J88_04315

SCAR:

DWB96_04715

SCHR:

DWB92_04145

SARL:

SAP2_09350

SPIC:

SAMEA4384060_1031(aldH)

SSH:	NCTC13712_01941(calB)

SSIM:

SAMEA4384339_1841(aldH)

SDB:	CNQ82_09420

SLLO:

ISP08_04560

SRAI:

LN051_03735

SPSD:

JMB28_05070

STAS:

HYI43_04865

SURY:

MUA21_08330

SEDA:

MNY58_04630

SCAQ:

QMO72_04595

SDEV:

Q2T90_02705

SROT:

ML435_09515

STAP:

AOB58_59

SSCU:

CEP64_03375

SFF:	FOB90_03705

SSTE:

SAMEA4384403_0759(aldH)

MLEN:

H3V22_04970

MVT:	I6J10_07365

MACR:

BHM04_00375

MARY:

LAU42_09760

MBRU:

MGG13_09295

MEPI:

KFV12_11020

MEQU:

KFV11_09435

MBOC:

QSV55_09575

MCL:

MCCL_1656

MCAK:

MCCS_21160(alkH)

MBOE:

HT586_10310

PALR:

HGI30_08165

SPOO:

J3U78_06760

STHO:

QNH10_10790

UTH:	DKZ56_06040

VLU:	M2919_01510

VLC:	G314FT_06580(aldH1)

VIE:	OL234_09655

JEM:	LZ578_05880

CINT:

HZF06_08110

LXA:	OW255_02140

AHB:	bsdtb5_31030(aldH)

TEM:	JW646_16765

TGC:	L0P85_11025

TMY:	TEMA_06960(aldH1)

PEB:	O0R46_01890

TBB:	J0J69_03605

TSF:	NQ543_10475

MANR:

MPAN_016780

MLY:	CJ228_009790

CFIL:

MYF79_02315

SSIY:

JVX97_14910

DCN:	MUK70_10645

PPSV:

PEPS_04960(aldH)

FAG:	K5I29_07655

FRR:	IB67_08655

» show all

Reference

1 [PMID:15933032]

Authors

Tao L, Schenzle A, Odom JM, Cheng Q

Title

Novel carotenoid oxidase involved in biosynthesis of 4,4'-diapolycopene dialdehyde.

Journal

Appl Environ Microbiol 71:3294-301 (2005)
DOI:10.1128/AEM.71.6.3294-3301.2005

Sequence

[ag:AAX46184]

Reference

2 [PMID:25326460]

Authors

Steiger S, Perez-Fons L, Cutting SM, Fraser PD, Sandmann G

Title

Annotation and functional assignment of the genes for the C30 carotenoid pathways from the genomes of two bacteria: Bacillus indicus and Bacillus firmus.

Journal

Microbiology 161:194-202 (2015)
DOI:10.1099/mic.0.083519-0

Other DBs

ExplorEnz - The Enzyme Database:

1.2.99.10

IUBMB Enzyme Nomenclature:

1.2.99.10

ExPASy - ENZYME nomenclature database:

1.2.99.10

BRENDA, the Enzyme Database:

1.2.99.10

DBGET integrated database retrieval system