KEGG ENZYME: 1.2.99.6

ENZYME: 1.2.99.6

Entry

EC 1.2.99.6                 Enzyme

Name

carboxylate reductase;
aldehyde:(acceptor) oxidoreductase

Class

Oxidoreductases;
Acting on the aldehyde or oxo group of donors;
With unknown physiological acceptors

Sysname

aldehyde:acceptor oxidoreductase

Reaction(IUBMB)

an aldehyde + acceptor + H2O = a carboxylate + reduced acceptor [RN:R00544]

Reaction(KEGG)

R00544 > R00326 R00638

Substrate

aldehyde [CPD:C00071];
acceptor [CPD:C00028];
H2O [CPD:C00001]

Product

carboxylate [CPD:C00060];
reduced acceptor [CPD:C00030]

Comment

A tungsten protein. Methyl viologen can act as acceptor. In the reverse direction, non-activated acids are reduced by reduced viologens to aldehydes, but not to the corresponding alcohols.

History

EC 1.2.99.6 created 1992

Pathway

ec00620

Pyruvate metabolism

Reference

1 [PMID:2550230]

Authors

White H, Strobl G, Feicht R, Simon H.

Title

Carboxylic acid reductase: a new tungsten enzyme catalyses the reduction of non-activated carboxylic acids to aldehydes.

Journal

Eur J Biochem 184:89-96 (1989)
DOI:10.1111/j.1432-1033.1989.tb14993.x

Other DBs

ExplorEnz - The Enzyme Database:

1.2.99.6

IUBMB Enzyme Nomenclature:

1.2.99.6

ExPASy - ENZYME nomenclature database:

1.2.99.6

BRENDA, the Enzyme Database:

1.2.99.6

CAS:	125008-36-8

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