KEGG   ENZYME: 1.20.2.1
Entry
EC 1.20.2.1                 Enzyme                                 
Name
arsenate reductase (cytochrome c);
arsenite oxidase (ambiguous)
Class
Oxidoreductases;
Acting on phosphorus or arsenic in donors;
With a cytochrome as acceptor
Sysname
arsenite:cytochrome c oxidoreductase
Reaction(IUBMB)
arsenite + H2O + 2 oxidized cytochrome c = arsenate + 2 reduced cytochrome c + 2 H+ [RN:R09787]
Reaction(KEGG)
R09787
Substrate
arsenite [CPD:C06697];
H2O [CPD:C00001];
oxidized cytochrome c
Product
arsenate [CPD:C11215];
reduced cytochrome c [CPD:C00126];
H+ [CPD:C00080]
Comment
A molybdoprotein containing iron-sulfur clusters. Isolated from alpha-proteobacteria. Unlike EC 1.20.9.1, arsenate reductase (azurin), it does not use azurin as acceptor.
History
EC 1.20.2.1 created 2011
Orthology
K08355  arsenite oxidase small subunit
K08356  arsenite oxidase large subunit
Genes
VSP: VS_II0658 VS_II0659
VTA: A0943 A0944 B1225 B1226
VSL: LTQ54_20390 LTQ54_20395
VSY: K08M4_35820(aioB) K08M4_35830(aioA_1)
MBS: MRBBS_1242(aoxB) MRBBS_1243(aoxA)
MPQ: ABA45_06345
MVS: MVIS_1833(aoxA)
MYA: MORIYA_1165 MORIYA_1166
AEH: Mlg_1558
SHAI: LMH63_04690 LMH63_04695
GAI: IMCC3135_25220
EPS: L0Y14_10895 L0Y14_10900
HSI: BOX17_13460 BOX17_13465
RSL: RPSI07_mp0919(aoxA) RPSI07_mp0920(aoxB)
RSG: JK151_18780 JK151_18785
CUH: BJN34_21510 BJN34_21515
CBW: RR42_s1794 RR42_s1795
CCUP: BKK81_17850 BKK81_17855 BKK81_22395
CUU: BKK79_24695 BKK79_24700
CUK: KB879_31230 KB879_31235
BOC: BG90_1022 BG90_1023
BVE: AK36_5595 AK36_5596
BMJ: BMULJ_05810(asoA) BMULJ_05811(asoB) BMULJ_05832(asoB) BMULJ_05833(asoA)
BMU: Bmul_5678 Bmul_5679 Bmul_5703 Bmul_5704
BMK: DM80_6068 DM80_6069 DM80_6143 DM80_6144
BURK: DM992_39955 DM992_39960
PARB: CJU94_00385 CJU94_00390
PGIS: I6I06_12610 I6I06_12615
PDIO: PDMSB3_0039.2(aioB) PDMSB3_0040.2(aioA)
PPNO: DA70_08845 DA70_08850
CABA: SBC2_73790(aioB) SBC2_73800(aioA)
TVL: FAZ95_24930 FAZ95_24935
AXX: ERS451415_05769(aioB) ERS451415_05770(aioA)
ADY: HLG70_07540 HLG70_07545
RFR: Rfer_3084 Rfer_3085
OTK: C6570_08745 C6570_08750
HPSE: HPF_13640(aioB)
HYN: F9K07_29420 F9K07_29425
HTN: KI616_13715 KI616_13720
DRG: H9K76_03270 H9K76_03275
HAR: HEAR0478(aoxB) HEAR0479(aoxA)
HEE: hmeg3_02275 hmeg3_02280
TIN: Tint_3061 Tint_3062
THI: THI_3162(aoxB) THI_3163(aoxA)
METR: BSY238_2675
SULF: CAP31_08915 CAP31_08920
SPLB: SFPGR_23330(soxF)
URU: DSM104443_02691
UPL: DSM104440_02414
AZD: CDA09_11970 CDA09_11975
ATW: C0099_09795 C0099_09800
BEBA: BWI17_13330
MOH: IHQ72_14000 IHQ72_14005
AAK: AA2016_4246 AA2016_4247
AMIH: CO731_03145(aioB) CO731_03146(aioA)
AMIS: Amn_21870 Amn_21880
SAME: SAMCFNEI73_pC1772(aioB) SAMCFNEI73_pC1773(aioA)
EAK: EKH55_4985 EKH55_4986
RHT: NT26_p10029(aioB) NT26_p10030(aioA)
BSEI: KMZ68_21350 KMZ68_21355
BPAH: QA639_35220
BRAZ: LRP30_02820 LRP30_02825
NHA: Nham_4426 Nham_4427
PCAX: AFIC_003115 AFIC_003116
BOF: FQV39_32090 FQV39_32095
XAU: Xaut_3949 Xaut_3950
SNO: Snov_1288 Snov_1289
ANC: GBB76_17085 GBB76_17090
MOC: BB934_26195 BB934_26200
CHEL: AL346_18905 AL346_18910
CDQ: BOQ54_03350 BOQ54_03355
BLAG: BLTE_10210 BLTE_10220
MSC: BN69_1400(aoxB) BN69_1401
MROS: EHO51_05095 EHO51_05100
AUZ: Sa4125_32580 Sa4125_32590
JAV: OXU80_17520 OXU80_17525
NOH: G5V57_02085 G5V57_02090
PSF: PSE_5043 PSE_5044
LABP: FJ695_09860 FJ695_09865
ACUT: MRB58_23145 MRB58_23150
CSE: Cseg_2507 Cseg_2508
RLI: RLO149_c022030(aoxA) RLO149_c022040(aoxB)
CON: TQ29_15470 TQ29_15475
SPSE: SULPSESMR1_00155(aioA) SULPSESMR1_00156(aioB)
AHT: ANTHELSMS3_01774(aioA) ANTHELSMS3_01775(aioB)
THAA: CFI11_15005 CFI11_15010
TGL: HFZ77_15760 HFZ77_15765
HAT: RC74_20735
PSEW: JHW44_16040 JHW44_16045
PSAP: JHX88_09005 JHX88_09010
DAA: AKL17_1594 AKL17_1595
PPSO: QPJ95_16145 QPJ95_16150
PAMO: BAR1_01585 BAR1_01590
PGV: SL003B_2333 SL003B_2334
NSM: JO391_20400 JO391_20405
AMV: ACMV_26640 ACMV_26650 ACMV_P2_00160 ACMV_P2_00170
SKU: Sulku_1032
SULR: B649_04295
SBA: Sulba_2413 Sulba_2414
SMUL: SMUL_3119(aioB) SMUL_3120(aioA)
SHAL: SHALO_2876 SHALO_2877
SULS: Sdiek1_1026 Sdiek1_1028
NIS: NIS_0033
BACI: B1NLA3E_03580
GST: HW35_13485
BACQ: DOE78_14710
BACA: FAY30_05805
BCO: Bcell_2932
BCOH: BC6307_03535
BON: A361_18050
CGOT: J1899_13040
CFIR: NAF01_16185
CSOA: LIS82_03630 LIS82_16610
CSPG: LS684_09815
VIR: X953_02020
VHL: BME96_01380
FEC: QNH15_19550
BSJ: UP17_09935
PBUT: DTO10_23785
PPSR: I6J18_11655
PFRI: L8956_11020
POF: GS400_18185
NMK: CHR53_05940
NDT: L1999_04460
NCM: QNK12_03900
NNV: QNH39_06015
MEKU: HUW50_24820
AIA: AWH56_015545
DOM: RRU94_00135
EAT: EAT1b_1905
BBE: BBR47_47180
BLR: BRLA_c027090
BFM: BP422_19300
BRW: GOP56_06075
PMS: KNP414_01413
PMQ: PM3016_1730
PMW: B2K_08810
ACUR: JZ785_04745 JZ785_04750
CAU: Caur_1209 Caur_1210
CHL: Chy400_1322 Chy400_1323
CAG: Cagg_0377 Cagg_0378
TTR: Tter_2537
DGE: Dgeo_1251
DDR: Deide_08260
DMR: Deima_1145
DPT: Deipr_0889
DPD: Deipe_0804
DSW: QR90_01820
DCH: SY84_03750
DAB: AUC44_05220
DPU: SU48_09115
DFC: DFI_03960
DEIN: DAAJ005_03325
DGA: DEGR_20740
TRA: Trad_0410
TTJ: TTHB127(TTHB127) TTHB128(TTHB128)
TTS: Ththe16_2239 Ththe16_2240
TSC: TSC_c14680(aoxB) TSC_c14700(aoxA)
TAQ: TO73_0834 TO73_0835
TBC: A0O31_02546 A0O31_02547
TANT: KNN15_12350 KNN15_12355
MRB: Mrub_2869
MRE: K649_08180
PND: Pla175_21920(aioB)
SUS: Acid_2926
PFER: IRI77_14250
ABAC: LuPra_00131(aioB)
CPB: Cphamn1_2364 Cphamn1_2365
CLI: Clim_0382 Clim_0383
HHO: HydHO_0313 HydHO_0314
HYS: HydSN_0324 HydSN_0325
TRD: THERU_04625 THERU_04630
NDE: NIDE3704(aoxA) NIDE3705(aoxB)
HALB: EKH57_17170 EKH57_17175
HLC: CHINAEXTREME13385 CHINAEXTREME13390
APE: APE_2556.1 APE_2563
ACJ: ACAM_1597 ACAM_1598
STO: STK_23910 STK_23920
SOH: D1869_13100 D1869_13105
SULA: BFU36_12340 BFU36_12370
SULL: EWF20_14140 EWF20_14145
MCN: Mcup_1604 Mcup_1611
MHK: DFR87_05070 DFR87_05105
MTEN: GWK48_00020 GWK48_11320
MJN: MjAS7_1216 MjAS7_1224
AHO: Ahos_1882 Ahos_1883
AMAN: B6F84_04000 B6F84_04010
ABRI: DFR85_00200 DFR85_00205 DFR85_00260
ASUL: DFR86_03900 DFR86_03910
ACIH: HS5_06700 HS5_06710
CSTY: KN1_02360 KN1_02370
STEP: IC006_2112 IC006_2120
SMET: RQ359_002115 RQ359_002123
PCL: Pcal_1369 Pcal_1370
PYR: P186_1845 P186_1846
POG: Pogu_0531 Pogu_0532
 » show all
Reference
1  [PMID:15178476]
  Authors
vanden Hoven RN, Santini JM
  Title
Arsenite oxidation by the heterotroph Hydrogenophaga sp. str. NT-14: the arsenite oxidase and its physiological electron acceptor.
  Journal
Biochim Biophys Acta 1656:148-55 (2004)
DOI:10.1016/j.bbabio.2004.03.001
Reference
2  [PMID:17306216]
  Authors
Santini JM, Kappler U, Ward SA, Honeychurch MJ, vanden Hoven RN, Bernhardt PV
  Title
The NT-26 cytochrome c552 and its role in arsenite oxidation.
  Journal
Biochim Biophys Acta 1767:189-96 (2007)
DOI:10.1016/j.bbabio.2007.01.009
Reference
3  [PMID:19525272]
  Authors
Branco R, Francisco R, Chung AP, Morais PV
  Title
Identification of an aox system that requires cytochrome c in the highly arsenic-resistant bacterium Ochrobactrum tritici SCII24.
  Journal
Appl Environ Microbiol 75:5141-7 (2009)
DOI:10.1128/AEM.02798-08
  Sequence
[ag:ACK38266 ACK38267]
Reference
4  [PMID:20421652]
  Authors
Lieutaud A, van Lis R, Duval S, Capowiez L, Muller D, Lebrun R, Lignon S, Fardeau ML, Lett MC, Nitschke W, Schoepp-Cothenet B
  Title
Arsenite oxidase from Ralstonia sp. 22: characterization of the enzyme and its interaction with soluble cytochromes.
  Journal
J Biol Chem 285:20433-41 (2010)
DOI:10.1074/jbc.M110.113761
Other DBs
ExplorEnz - The Enzyme Database: 1.20.2.1
IUBMB Enzyme Nomenclature: 1.20.2.1
ExPASy - ENZYME nomenclature database: 1.20.2.1
BRENDA, the Enzyme Database: 1.20.2.1

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Chemical substance (6)   
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Chemical reaction (1)   
   KEGG REACTION (1)   
Gene (1497)   
   KEGG ORTHOLOGY (2)   
   KEGG GENES (340)   
   KEGG MGENES (868)   
   RefGene (287)   
Protein sequence (3)   
   UniProt (3)   
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