Entry |
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Name |
methylarsonate reductase;
MMA(V) reductase
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Class |
Oxidoreductases;
Acting on phosphorus or arsenic in donors;
With disulfide as acceptor
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Sysname |
methylarsonate:glutathione oxidoreductase
|
Reaction(IUBMB) |
methylarsonate + 2 glutathione = methylarsonite + glutathione disulfide + H2O [RN: R05748]
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Reaction(KEGG) |
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Substrate |
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Product |
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Comment |
The product, methylarsonite, is biologically methylated by EC 2.1.1.137, arsenite methyltransferase, to form cacodylic acid.
|
History |
EC 1.20.4.2 created 2000 as EC 1.97.1.7, transferred 2001 to EC 1.20.4.2, modified 2003
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Reference |
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Authors |
Zakharyan RA, Aposhian HV. |
Title |
Enzymatic reduction of arsenic compounds in mammalian systems: the rate-limiting enzyme of rabbit liver arsenic biotransformation is MMA(V) reductase. |
Journal |
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Other DBs |
ExplorEnz - The Enzyme Database: | 1.20.4.2 |
ExPASy - ENZYME nomenclature database: | 1.20.4.2 |
UM-BBD (Biocatalysis/Biodegradation Database): | 1.20.4.2 |
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