KEGG   ENZYME: 1.21.3.10
Entry
EC 1.21.3.10                Enzyme                                 
Name
hercynylcysteine S-oxide synthase;
Egt1;
Egt-1
Class
Oxidoreductases;
Catalysing the reaction X-H + Y-H = X-Y;
With oxygen as acceptor
Sysname
hercynine,L-cysteine:oxygen [S-(hercyn-2-yl)-L-cysteine S-oxide-forming]
Reaction(IUBMB)
hercynine + L-cysteine + O2 = S-(hercyn-2-yl)-L-cysteine S-oxide + H2O [RN:R11014]
Reaction(KEGG)
R11014
Substrate
hercynine [CPD:C05575];
L-cysteine [CPD:C00097];
O2 [CPD:C00007]
Product
S-(hercyn-2-yl)-L-cysteine S-oxide [CPD:C20994];
H2O [CPD:C00001]
Comment
Requires Fe2+ for activity. The enzyme, found in fungal species, is part of a fusion protein that also has the the activity of EC 2.1.1.44, L-histidine Nalpha-methyltransferase. It is part of the biosynthesis pathway of ergothioneine. The enzyme can also use L-selenocysteine to produce hercynylselenocysteine, which can be converted to selenoneine.
History
EC 1.21.3.10 created 2015 as 1.14.99.51, transferred 2022 to EC 1.21.3.10
Pathway
ec00340  Histidine metabolism
ec01100  Metabolic pathways
Orthology
K20246  L-histidine Nalpha-methyltransferase / hercynylcysteine S-oxide synthase
Genes
NCRNCU04343(egt-1)
NTENEUTE1DRAFT145472(NEUTE1DRAFT_145472)
SMPSMAC_01803
PBELQC761_303570(EGT1)
PPSDQC762_303570(EGT1)
PPSPQC763_303570(EGT1)
PPSAQC764_303570(EGT1)
MTMMYCTH_2074210
CTHRCTHT_0030600
MGRMGG_00020 MGG_13219
PPEIPpBr36_02899
PGRIPgNI_01802
TMNUCRPA7_3011
SSCKSPSK_08945
FGRFGSG_03421 FGSG_11987 FGSG_12773
FPUFPSE_06241 FPSE_08378 FPSE_11477
FPOAFPOAC1_005802 FPOAC1_008076(EGT1)
FVNFVRRES_06401 FVRRES_08641
FVRFVEG_15947
FOXFOXG_20012
NHENECHADRAFT_70968 NECHADRAFT_97208
FFCNCS54_01025400
FKRNCS57_01018600 NCS57_01307200
FMUJ7337_009501(EGT1)
TRETRIREDRAFT_81410
TRRM419DRAFT_103267
MAWMAC_09617
MAJMAA_04856
PCHMVFPPC_14279
CMTCCM_07351
AMUSLMH87_009924
PLJVFPFJ_01447
PTKZJDV02_003062(EGT1_2)
VDAVDAG_10242
CFJCFIO01_13296
CLUPCLUP02_15291
CHIGCH63R_04852
SAPOSAPIO_CDS7015
PFYPFICI_05616
BFUBCIN_12g04180
MBEMBM_01989
PSCOLY89DRAFT_586353
GLZGLAREA_08265
ANIANIA_10996
AFMAFUA_2G15650
ACTACLA_074540
NFINFIA_090880
AORAO090012000265 AO090023000415
ANGAn15g05880
AFVAFLA_001980 AFLA_006763
ALUCAKAW2_60182A
ACHEACHE_10907A ACHE_60451S
APUUAPUU_80300A
PDPPDIP_81160
POUPOX_d05123
TMFEYB26_002139
TRGTRUGW13939_05155
CIMCIMG_00276
CPWCPC735_059060
UREUREG_00352
PBLPAAG_03909
PBNPADG_11594
ABEARB_02453
TVETRV_08045
AJEHCAG_01026
BGHBDBG_06484
PNOSNOG_13930(SNOG_13929)
PTEPTT_06791
BZECOCCADRAFT_109454
BSCCOCSADRAFT_32544
BORCOCMIDRAFT_95519
AALTCC77DRAFT_949140
ARABEKO05_0009390
ZTRMYCGRDRAFT_75935
PFJMYCFIDRAFT_56905
FFUCLAFUR5_11164
CBETCB0940_06825
BCOMBAUCODRAFT_116776
NPAUCRNP2_8392
SPOSPBC1604.01(mug158)
SOMSOMG_00523(egt1)
CNECNJ01670
CNBCNBJ1790
CNGCNAG_04737
CGICGB_I2320W
CDEUCNBG_6003
TMSTREMEDRAFT_42626
TASAA1Q1_06211
TVSTRAVEDRAFT_64341
DSQDICSQDRAFT_55495
PCOPHACADRAFT_212229
SHSSTEHIDRAFT_66030
HIRHETIRDRAFT_156207
PSQPUNSTDRAFT_131244
ADLAURDEDRAFT_115403
FMEFOMMEDRAFT_78835
GTRGLOTRDRAFT_139012
RSXRhiXN_01637
LBCLACBIDRAFT_188236
CCICC1G_02949
ABPAGABI1DRAFT120644(AGABI1DRAFT_120644)
ABVAGABI2DRAFT186400(AGABI2DRAFT_186400)
PCUBJR316_0007212
MRRMoror_1006
MOREE1B28_012164
SCMSCHCO_02619710(SCHCODRAFT_02619710)
CPUTCONPUDRAFT_77468 CONPUDRAFT_85801
SLASERLADRAFT_470869
WSEWALSEDRAFT_60925
WICJ056_001286
SGRAEX895_000427
PGRPGTG_04084
PTRCPtA15_2A358 PtA15_9A275
PSTRPst134EA_020867
MLRMELLADRAFT_110519
 » show all
Reference
1  [PMID:24828577]
  Authors
Pluskal T, Ueno M, Yanagida M
  Title
Genetic and metabolomic dissection of the ergothioneine and selenoneine biosynthetic pathway in the fission yeast, S. pombe, and construction of an overproduction system.
  Journal
PLoS One 9:e97774 (2014)
DOI:10.1371/journal.pone.0097774
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 1.21.3.10
IUBMB Enzyme Nomenclature: 1.21.3.10
ExPASy - ENZYME nomenclature database: 1.21.3.10
BRENDA, the Enzyme Database: 1.21.3.10

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