| Entry |
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| Name |
columbamine oxidase;
berberine synthase
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| Class |
Oxidoreductases;
Catalysing the reaction X-H + Y-H = X-Y;
With oxygen as acceptor
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| Sysname |
columbamine:oxygen oxidoreductase (cyclizing)
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| Reaction(IUBMB) |
2 columbamine + O2 = 2 berberine + 2 H2O [RN: R00044]
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| Reaction(KEGG) |
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| Substrate |
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| Product |
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| Comment |
An iron protein. Oxidation of the O-methoxyphenol structure forms the methylenedioxy group of berberine.
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| History |
EC 1.21.3.2 created 1989 as EC 1.1.3.26, transferred 2002 to EC 1.21.3.2
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| Pathway |
| ec00950 | Isoquinoline alkaloid biosynthesis |
| ec01110 | Biosynthesis of secondary metabolites |
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| Reference |
1 |
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| Authors |
Rueffer, M. and Zenk, M.H. |
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| Title |
Berberine synthesis, the methylenedioxy group forming enzyme in berberine synthesis. |
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| Journal |
Tetrahedron Lett 26:201-202 (1985) |
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| Other DBs |
| ExplorEnz - The Enzyme Database: | 1.21.3.2 |
| ExPASy - ENZYME nomenclature database: | 1.21.3.2 |
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