KEGG ENZYME: 1.3.1.104

ENZYME: 1.3.1.104

Entry

EC 1.3.1.104                Enzyme

Name

enoyl-[acyl-carrier-protein] reductase (NADPH);
acyl-ACP dehydrogenase (ambiguous);
enoyl-[acyl carrier protein] (reduced nicotinamide adenine dinucleotide phosphate) reductase;
NADPH 2-enoyl Co A reductase;
enoyl-ACP reductase (ambiguous);
fabL (gene name)

Class

Oxidoreductases;
Acting on the CH-CH group of donors;
With NAD+ or NADP+ as acceptor

Sysname

acyl-[acyl-carrier protein]:NADP+ oxidoreductase

Reaction(IUBMB)

an acyl-[acyl-carrier protein] + NADP+ = a trans-2,3-dehydroacyl-[acyl-carrier protein] + NADPH + H+ [RN:R01404]

Reaction(KEGG)

R01404 > R04430 R04725 R04956 R04959 R04962 R04967 R04970

Substrate

acyl-[acyl-carrier protein] [CPD:C00173];
NADP+ [CPD:C00006]

Product

trans-2,3-dehydroacyl-[acyl-carrier protein] [CPD:C00693];
NADPH [CPD:C00005];
H+ [CPD:C00080]

Comment

The enzyme completes each cycle of fatty acid elongation by catalysing the stereospecific reduction of the double bond at position 2 of a growing fatty acid chain, while linked to the acyl-carrier protein, in an NADPH-dependent manner. This entry stands for enzymes whose stereo-specificity with respect to NADP+ is not known. [cf. EC 1.3.1.39 enoyl-[acyl-carrier-protein] reductase (NADPH, Re-specific), EC 1.3.1.10, enoyl-[acyl-carrier-protein] reductase (NADPH, Si-specific) and EC 1.3.1.9, enoyl-[acyl-carrier-protein] reductase (NADH)].

History

EC 1.3.1.104 created 2013

Pathway

ec00061

Fatty acid biosynthesis

ec01100

Metabolic pathways

Orthology

K10780

enoyl-[acyl-carrier protein] reductase III

Genes

SMAF:

D781_2232

SFW:	WN53_21285

SFG:	AV650_17030

SRZ:	AXX16_2910

SERM:

CLM71_11550

SRHZ:

FO014_22215

PALC:

A0T30_17150

PCAM:

HNE05_12885

LPH:

LPV_0452

LPO:

LPO_0408

LPU:	LPE509_02876

LPM:	LP6_0350(fabL)

LPA:

lpa_00572

LPE:

lp12_0359

LLO:

LLO_0519

LFA:	LFA_2780(fabL)

LHA:	LHA_0370(fabL)

LOK:

Loa_00420

LCD:	clem_13305(fabL)

LSH:	CAB17_06780(fabL)

LLG:	44548918_00264(fabL)

LIB:	E4T55_06160(fabL)

LGT:	E4T54_04805(fabL)

LJR:	NCTC11533_00288(fabL)

LCJ:	NCTC11976_01126(fabL) NCTC11976_02509(phaB_4)

LWA:	SAMEA4504053_0677(fabL)

LSS:	NCTC12082_02402(fabL)

TMC:	LMI_0465(fabL)

BMAR:

HF888_13400

GBI:	PG2T_08100

PPAI:

E1956_04250

BOZ:	DBV39_18780(fabL)

VEI:

Veis_2543

RBS:	RHODOSMS8_02171(fabL)

RDI:	CMV14_20020

DLM:	DPPLL_21860(fabL)

DPR:	Despr_0937

DDU:	GF1_05560(fabL)

ECOM:

QTN59_07475(fabL)

MSD:	MYSTI_06026

CCX:	COCOR_02185(fabG9)

MFU:	LILAB_25050

SUR:	STAUR_4694 STAUR_7038

AGE:	AA314_01964 AA314_07156

AVM:	JQX13_22655

MBD:	MEBOL_004393

CFUS:

CYFUS_001265

CCRO:

CMC5_023740

MRM:	A7982_00886 A7982_02081

SAMY:

DB32_005294

LLU:	AKJ09_02466

BSU:	BSU08650(fabL)

BSR:

I33_0968

BSL:

A7A1_0300

BSH:	BSU6051_08650(fabL)

BSY:	I653_04335

BSUT:

BSUB_00939(fabL)

BSUL:

BSUA_00939(fabL)

BSUS:

Q433_04825

BSO:	BSNT_07250(fabL)

BSN:	BSn5_16190

BSQ:	B657_08650(fabL)

BSX:	C663_0887(fabL)

BSP:	U712_04400

BSS:	BSUW23_04355(fabL)

BST:

GYO_1133

BIT:	BIS30_14905

BLI:	BL03039(fabL)

BLD:	BLi00887(fabL)

BLH:	BaLi_c09910(fabL)

BAY:	RBAM_008740(fabL)

BAQ:	BACAU_0849(fabL)

BYA:	BANAU_0792(fabL)

BAMP:

B938_04215

BQY:	MUS_0887(fabL)

BAML:

BAM5036_0783(fabL)

BAMA:

RBAU_0847(fabL)

BAMN:

BASU_0823(fabL)

BAMB:

BAPNAU_0805(fabL)

BAMT:

AJ82_04870

BAMY:

V529_08190(fabL)

BMP:	NG74_00869(fabL)

BAO:	BAMF_0873(fabL)

BAZ:	BAMTA208_03980(fabL)

BQL:	LL3_00935(fabL)

BXH:	BAXH7_00830(fabL)

BAMI:

KSO_015445

BAMC:

U471_08640

BAMF:

U722_04360

BSIA:

CWD84_17480

BAE:	BATR1942_01895

BVM:	B9C48_04330

BSON:

S101395_01084(phbB)

BHT:	DIC78_05445(fabL)

BMOJ:

HC660_08980(fabL)

BTEQ:

G4P54_04520(fabL)

BIQ:	AN935_04495

BSTR:

QI003_04650(fabL)

BPU:

BPUM_0812

BPUM:

BW16_04360

BPUS:

UP12_04370

BIF:	N288_05665

BMET:

BMMGA3_03445(fabL)

BSM:	BSM4216_0820

BGY:	BGLY_0909(fabL)

BWH:	A9C19_16770

BXI:	BK049_03945

BALT:

CFN77_04250(fabL)

BAER:

BAE_11815

BSAF:

BSL056_04215

BFD:	NCTC4823_02971(fabL)

BSHI:

LGQ02_04825(fabL)

BBAD:

K7T73_03305(fabL)

BCAB:

EFK13_04855(fabL)

BRY:	M0696_04835(fabL)

BJS:

MY9_0954

BACI:

B1NLA3E_03370

GST:	HW35_14250

BACW:

QR42_04160

BACP:

SB24_05545

BACB:

OY17_07015

BACY:

QF06_03160

BACL:

BS34A_09630(fabL)

BALM:

BsLM_0900

BACS:

AUL54_06290

BACQ:

DOE78_05160(fabL)

BACA:

FAY30_06395(fabL)

BAQU:

K6959_02525(fabL)

BZH:	NF868_03600(fabL)

BHAI:

KJK41_06355(fabL)

BAEI:

RE735_15245(fabL)

BCO:	Bcell_0978

BHK:	B4U37_05220

BCIR:

C2I06_23175

NTX:	NQZ71_18495(fabL)

BMQ:

BMQ_0404

BMD:

BMD_0405

BMH:	BMWSH_4822(fabL)

BMEG:

BG04_2695(fabL)

BEO:

BEH_02810

BFX:	BC359_18390

PKS:	IE339_02595(fabL)

BHA:

BH0938

BCL:	ABC1313(fabL)

BLE:	BleG1_1207

SHUA:

PQ477_14510(fabL)

BGI:	BGM20_19495

BPF:	BpOF4_10865

BON:	A361_06105

BKO:	CKF48_03275

CGOT:

J1899_04845(fabL)

CSUA:

IM538_02670(fabL)

CFIR:

NAF01_05770(fabL)

CSOA:

LIS82_05480(fabL)

CSPG:

LS684_03950(fabL)

CPSS:

M5V91_15660(fabL)

BDA:	FSZ17_06550(fabL)

GKA:

GK0465

GTE:	GTCCBUS3UF5_5810

GTK:	GT3570_02290

GTM:	GT3921_16915

GLI:	GLN3_12750

BCAL:

CWI35_07755

GTN:	GTNG_0470(fabI)

GWC:	GWCH70_0470

GYC:	GYMC61_1347

GYA:	GYMC52_0468

GCT:	GC56T3_3006

GMC:	GY4MC1_3310

GGH:	GHH_c04870(fabL)

GJF:	M493_02735

GEA:	GARCT_00511(fabL)

GEL:	IB49_12935

GSE:	GT50_12145

GSR:	GS3922_13360

GEJ:	A0V43_18130

GZA:	IC807_16070(fabL)

GTH:	Geoth_3364

PTL:	AOT13_05915

PTB:	DER53_06955(fabL)

PCAL:

BV455_01279(fabL)

PARG:

PspKH34_32790(fabL)

ANM:	GFC28_2058(fabL)

AAMY:

GFC30_882(fabL)

ANL:	GFC29_3376(fabL)

AND:	GRQ40_02945(fabL)

ACAI:

ISX45_18400(fabL)

ASED:

IRT44_09025(fabL)

FEC:	QNH15_12635(fabL)

APAK:

AP3564_02345

ACOP:

RI196_15135(fabL)

BSJ:	UP17_03800

BMUR:

ABE28_003640

PBUT:

DTO10_15160(fabL)

PASA:

BAOM_0748(fabL)

PPSR:

I6J18_10860(fabL)

PFRI:

L8956_03850(fabL)

BTHV:

CQJ30_05400

PSYH:

D0S48_17065(fabL)

PSYO:

PB01_15925(fabL)

PSYB:

KD050_06060(fabL)

RUE:	DT065_17745(fabL)

SALE:

EPH95_17465(fabL)

SCIB:

HUG20_05875(fabL)

SCIA:

HUG15_08260(fabL)

NMK:	CHR53_06670

NDT:	L1999_05165(fabL)

NCM:	QNK12_05235(fabL)

NNV:	QNH39_06795(fabL)

MEKU:

HUW50_12015(fabL)

MSEM:

GMB29_02775(fabL)

MDG:	K8L98_03440(fabL)

MLIT:

KDJ21_001880(fabL)

AIA:	AWH56_003345(fabL)

BLEN:

NCTC4824_03129(fabL)

BVQ:	FHE72_06720(fabL)

RMF:	D5E69_07415(fabL)

RAZ:	U9J35_06720(fabL)

BCK:	BCO26_2328

BAG:

Bcoa_2111

BCOA:

BF29_1474(fabL)

BVJ:	I5776_16130(fabL)

BOU:	I5818_19755(fabL)

MCUI:

G8O30_01735(fabL)

PSUA:

FLK61_28145(fabL)

SLMS:

MM221_15895(fabL)

MJO:	FOF60_05100(fabL)

MSUT:

LC048_16725(fabL)

SFOR:

QNH23_10385(fabL)

ECTO:

MUG87_03860(fabL)

ALKL:

MM271_04935(fabL)

DOM:	RRU94_21925(fabL)

AHAL:

FTX54_005865(fabL)

STEA:

C0679_05560

PUK:	PU629_11165 PU629_12465(fabL) PU629_17860(fabL)

LMO:

lmo1688

LMN:	LM5578_1835

LMY:	LM5923_1787

LMT:	LMRG_02762

LMOC:

LMOSLCC5850_1751(fabL)

LMOE:

BN418_2021

LMOB:

BN419_2025

LMOD:

LMON_1755

LMOW:

AX10_02655

LMOQ:

LM6179_02444(fabL)

LMR:	LMR479A_1790(fabL)

LMOM:

IJ09_01415

LMF:	LMOf2365_1712

LMC:	Lm4b_01702

LMOG:

BN389_17160(fabL)

LMP:

MUO_08685

LMOL:

LMOL312_1695(fabL)

LMOJ:

LM220_01906

LMOZ:

LM1816_07017(fabL)

LMOX:

AX24_06135

LMH:	LMHCC_0876

LMQ:	LMM7_1777(fabL)

LML:	lmo4a_1745(fabL)

LMG:	LMKG_02669

LMS:

LMLG_1553

LMJ:	LMOG_02840

LMW:	LMOSLCC2755_1700(fabL)

LMX:	LMOSLCC2372_1754(fabL)

LMZ:	LMOSLCC2482_1752(fabL)

LMON:

LMOSLCC2376_1647(fabL)

LMOS:

LMOSLCC7179_1662(fabL)

LMOO:

LMOSLCC2378_1709(fabL)

LMOY:

LMOSLCC2479_1752(fabL)

LMOT:

LMOSLCC2540_1771(fabL)

LMOA:

LMOATCC19117_1703(fabL)

LMOK:

CQ02_08775

LMV:	Y193_07125(fabL)

LIN:

lin1796

LWE:

lwe1706

LSG:

lse_1656

LIV:

LIV_1663

LII:	JL52_08810

LIW:	AX25_08970

LIA:	JL58_08955

LIO:	JL53_09420

LWI:	UE46_10530

LGZ:	NCTC10812_01163(fabL)

LMAR:

LAX80_008225(fabL)

LNW:	OTR81_11055(fabL)

BTHS:

CNY62_10305

BBE:	BBR47_10320(fabL)

BLR:	BRLA_c007290(fabL)

BFM:	BP422_00280

BAGR:

BA6348_23750

BRW:	GOP56_19540(fabL)

BCOP:

JD108_18300(fabL)

BPAB:

PSE45_05150(fabL)

BHUI:

LOK74_01630(fabL)

BAYD:

BSPP4475_16895(fabL)

BBOR:

RFB14_20965(fabL)

BRUM:

NDK47_21850(fabL)

PBJ:	VN24_23250

ASOC:

CB4_03899(fabL_1)

AAC:	Aaci_2398 Aaci_2412

AAD:	TC41_2687(fabG) TC41_2700(fabL)

AFX:	JZ786_19250(fabL) JZ786_19315

AACO:

K1I37_18445 K1I37_18565(fabL)

ADAU:

NZD86_04905(fabL) NZD86_04985

AFAS:

NZD89_04880(fabL) NZD89_04935

ACYC:

JI721_14715 JI721_16895(fabL)

BTS:

Btus_2604

KYR:	CVV65_13045

TUM:	CBW65_01130

TAB:	CIG75_05115

EFF:	skT53_19840(fabL)

PLN:	Plano_0800

PKU:	AUO94_12280

PRT:	AUC31_05130

PLL:	I858_003125

PANA:

BBH88_16255

PDG:	BCM40_11645

PHC:	BBI08_00375

PMAR:

B0X71_04815

PPLA:

BBI15_00615

PFAE:

AJGP001_04920

PLX:	CW734_06355

PMAT:

BBI11_05800

PDEC:

H1Q58_04960(fabL)

PGQ:	FK545_12995(fabL)

JEO:

JMA_12600

SPSY:

AZE41_03675

SPAE:

E2C16_00445(fabL)

SURL:

BI350_04045

PAEK:

D3873_10330(fabL)

PANC:

E2636_04035(fabL)

PLAY:

DNR44_015760(fabL)

SAY:	TPY_3095 TPY_3240(fabL)

SAP:	Sulac_0799 Sulac_1673

HFV:

R50_2604

LXA:	OW255_06910

LPIL:

LIP_1119

MMOR:

MMOR_36050(fabL)

NBR:	O3I_026240

NSL:	BOX37_17080

NOZ:	DMB37_02610

ROA:	Pd630_LPD04497

DIZ:	CT688_13190

SGB:

WQO_30010

SVL:	Strvi_8195

SHY:

SHJG_1192

SHO:	SHJGH_1027

SRC:	M271_30645

SMAL:

SMALA_2908

SSOI:

I1A49_18470

SFA:

Sfla_5328

SBH:	SBI_06749 SBI_06855

STRP:

F750_1295

SLE:	sle_01250(sle_01250)

SGS:	AVL59_46205

SAUO:

BV401_18195

SVU:	B1H20_30845

SALF:

SMD44_08690

SKA:	CP970_38055

SSPO:

DDQ41_16075

SSEO:

D0Z67_12220

SSPB:

CP982_05330

SPLA:

CP981_34470

SCAL:

I6J39_30650

SGJ:	IAG43_17255

STUB:

MMF93_28535

SANT:

QR300_26900

SHAU:

K9S39_12925

LXL:	KDY119_01212

MIO:	AOA12_09960

MPAL:

BO218_02695

MIH:	BJP65_01770

MAUR:

BOH66_10360

MOO:	BWL13_01459(fabL)

MPRT:

ET475_01045

CUB:	BJK06_01395

FSB:	GCM10025867_34250

CPHY:

B5808_12155

HUM:	DVJ78_08790

HUW:	FPZ11_10075

GRY:	D7I44_00415

HEA:	HL652_11045

CELZ:

E5225_00720

CCHE:

NP064_11490

PSEI:

GCE65_03975

MIK:	FOE78_00275

MICG:

GJV80_19840

NDK:	I601_1166(fabL)

AWN:	NQV15_07675 NQV15_14330

AGRA:

AGRA3207_002235

NOA:	BKM31_45865

ACE:

Acel_1197

AMYY:

YIM_26855(fabL)

PDX:

Psed_2586

KAL:

KALB_7822

KUT:	JJ691_15740 JJ691_19750

MICH:

FJK98_15115

MCAB:

HXZ27_30090

PLAB:

C6361_09525

PLAT:

C6W10_06020

ATL:	Athai_27180

ASER:

Asera_47540

CATI:

CS0771_54770(fabL)

AFO:

Afer_1057

AQZ:	KSP35_11145

NON:	NOS3756_03710

ATM:

ANT_17280

PSUB:

Pelsub_P1998

CAP:	CLDAP_22810

KBS:	EPA93_26395

TTR:

Tter_0966

TRO:

trd_0268

STI:

Sthe_0993

RBA:	RB10454(chcA)

LCRE:

Pla8534_03000(fabL_1) Pla8534_16180(fabL_2)

AAGG:

ETAA8_31190(fabL)

BVO:	Pan97_33970(fabL_2)

BREM:

PSR63_21170

SMAM:

Mal15_43370(fabL_1)

SNEP:

Enr13x_06110(fabL_1)

PLM:

Plim_1674

PEH:	Spb1_25250(fabL)

MRI:	Mal4_48560(fabL_2)

PLON:

Pla110_25280(fabL)

CCOP:

Mal65_35400(fabL)

ORP:	MOP44_06185

SUS:

Acid_2156

CPI:

Cpin_5032

CHIH:

GWR21_30980

SGN:	SGRA_1403(fabI)

MUP:	A0256_07540

MUC:

MuYL_2694

MGOT:

MgSA37_02494(fabL)

MGIN:

FRZ54_06410

MGK:	FSB76_12515

MMAB:

HQ865_23795

MGIK:

GO620_015025

SLI:

Slin_3188

SRD:	SD10_17175

SPIR:

CWM47_06615

SPIK:

EXU85_33670

SFOL:

H3H32_29190

GFO:	GFO_1609(fabI)

GRL:	LPB144_03625

GRS:	C7S20_14460

RBI:	RB2501_14724

CAT:	CA2559_10903

MARM:

YQ22_18190

MART:

BTR34_17885

MARB:

CJ263_18640

MARE:

EJ994_04390

CAO:	Celal_3842

CBAL:

M667_15700

KDI:	Krodi_2526

DOK:	MED134_04719

DDO:	I597_1946(fabL)

DOD:	DCS32_14685

LACI:

CW733_13200

LNU:	N7U66_12060

ZGA:	ZOBELLIA_4386

ASL:	Aeqsu_2711

PTQ:	P700755_000481

NDO:

DDD_3154

NOM:	AAT17_01000

NSD:	BST91_04905

NOB:	CW736_10875

NOJ:	EJ995_09005

POM:	MED152_08610

WIJ:	BWZ20_08860

SYI:	SB49_03770

TJE:	TJEJU_0277

SALT:

AO058_12230

SMIS:

LDL76_14585

OLL:	CW732_02590

AUE:	C5O00_12550

KAN:	IMCC3317_45070(fabL)

AQD:	D1816_03765

EMAR:

D1013_12460

MUR:	EQY75_06045

PPON:

MUN68_017095

AFLA:

FHG64_01250

ANP:	FK178_04090

OCI:	FEZ18_06955

MGEL:

G5B37_02090

GAA:	HX109_13950

CAGG:

HYG79_16880

ALTI:

ALE3EI_2232

MUT:	GVT53_13935

SPON:

HME9304_03191(fabI)

FBE:	FF125_04625

CSAL:

NBC122_00026(fabL)

CHRC:

QGN23_05500

CJG:	NCTC13459_00416(fabL)

CCAS:

EIB73_04505

CANT:

NCTC13489_01022(fabL)

KDA:	EIB71_08845

KFA:	Q73A0000_01465

KAQ:	L0B70_11685

OHO:	Oweho_0671

CPH:	Cpha266_1101

PROW:

OO006_13155

PROI:

OO005_12130

CTS:

Ctha_2098

IAL:

IALB_0753

MRO:

MROS_0289

CABY:

Cabys_861

MOX:

DAMO_2491

» show all

Reference

1 [PMID:11007778]

Authors

Heath RJ, Su N, Murphy CK, Rock CO

Title

The enoyl-[acyl-carrier-protein] reductases FabI and FabL from Bacillus subtilis.

Journal

J Biol Chem 275:40128-33 (2000)
DOI:10.1074/jbc.M005611200

Sequence

[bsu:BSU08650]

Reference

2 [PMID:17329825]

Authors

Kim KH, Park JK, Ha BH, Moon JH, Kim EE

Title

Crystallization and preliminary X-ray crystallographic analysis of enoyl-ACP reductase III (FabL) from Bacillus subtilis.

Journal

Acta Crystallogr Sect F Struct Biol Cryst Commun 63:246-8 (2007)
DOI:10.1107/S1744309107008469

Reference

3 [PMID:21185310]

Authors

Kim KH, Ha BH, Kim SJ, Hong SK, Hwang KY, Kim EE

Title

Crystal structures of Enoyl-ACP reductases I (FabI) and III (FabL) from B. subtilis.

Journal

J Mol Biol 406:403-15 (2011)
DOI:10.1016/j.jmb.2010.12.003

Other DBs

ExplorEnz - The Enzyme Database:

1.3.1.104

IUBMB Enzyme Nomenclature:

1.3.1.104

ExPASy - ENZYME nomenclature database:

1.3.1.104

BRENDA, the Enzyme Database:

1.3.1.104

DBGET integrated database retrieval system