KEGG ENZYME: 1.3.1.113

ENZYME: 1.3.1.113

Entry

EC 1.3.1.113                Enzyme

Name

(4-alkanoyl-5-oxo-2,5-dihydrofuran-3-yl)methyl phosphate reductase;
bprA (gene name);
scbC (gene name)

Class

Oxidoreductases;
Acting on the CH-CH group of donors;
With NAD+ or NADP+ as acceptor

Sysname

[(3S,4R)-4-alkanoyl-5-oxooxolan-3-yl]methyl-phosphate:NADP+ oxidoreductase

Reaction(IUBMB)

a [(3S,4R)-4-alkanoyl-5-oxooxolan-3-yl]methyl phosphate + NADP+ = a (4-alkanoyl-5-oxo-2,5-dihydrofuran-3-yl)methyl phosphate + NADPH + H+ [RN:R11927]

Reaction(KEGG)

R11927

Substrate

[(3S,4R)-4-alkanoyl-5-oxooxolan-3-yl]methyl phosphate [CPD:C21773];
NADP+ [CPD:C00006]

Product

(4-alkanoyl-5-oxo-2,5-dihydrofuran-3-yl)methyl phosphate [CPD:C21774];
NADPH [CPD:C00005];
H+ [CPD:C00080]

Comment

The enzyme, characterized from the bacteria Streptomyces griseus and Streptomyces coelicolor, is involved in the biosynthesis of gamma-butyrolactone autoregulators that control secondary metabolism and morphological development in Streptomyces bacteria.

History

EC 1.3.1.113 created 2017

Orthology

K22462

(4-alkanoyl-5-oxo-2,5-dihydrofuran-3-yl)methyl phosphate reductase

Genes

NYU:	D7D52_00040

SCO:	SCO6267(SCAH10.32)

SMA:	SAVERM_3525

SGR:

SGR_6890

SGB:

WQO_00735

SFI:

SFUL_270

SANL:

KZO11_00305

SCYE:

R2B67_35420

SHY:	SHJG_4002 SHJG_8652

SHO:	SHJGH_3767 SHJGH_8412

SSOI:

I1A49_09945

SDV:	BN159_2281

SLV:	SLIV_06810

SGU:	SGLAU_25505

SVT:	SVTN_03090

SCZ:	ABE83_34270

SRW:	TUE45_pSRc_0611(azoB)

SPAV:

Spa2297_32645

SCAD:

DN051_10580

SLS:	SLINC_6538

SSIA:

A7J05_00555

SVU:	B1H20_00405

SLX:	SLAV_40305(azoB6)

SGZ:	C0216_31800

SNK:	CP967_15140 CP967_31570

SFIC:

EIZ62_19135

SPAD:

DVK44_34910

SCAV:

CVT27_00250

SCIN:

CP977_28625

SPAC:

B1H29_00925 B1H29_36140

SCOE:

CP976_35715

SSPB:

CP982_41460

SCAL:

I6J39_00525

SXN:	IAG42_36220

SGJ:	IAG43_33755

SDD:	D9753_04945

SYAN:

NRK68_34930

SCIR:

STRCI_006304

SXT:	KPP03845_300020(azoB_2)

SDRZ:

NEH16_32600

SCOA:

QU709_08710

KAB:	B7C62_00285

STRH:

GXP74_38580

KBU:	Q4V64_40360

» show all

Reference

1 [PMID:17277085]

Authors

Kato JY, Funa N, Watanabe H, Ohnishi Y, Horinouchi S

Title

Biosynthesis of gamma-butyrolactone autoregulators that switch on secondary metabolism and morphological development in Streptomyces.

Journal

Proc Natl Acad Sci U S A 104:2378-83 (2007)
DOI:10.1073/pnas.0607472104

Reference

2 [PMID:29510026]

Authors

Biarnes-Carrera M, Lee CK, Nihira T, Breitling R, Takano E

Title

Orthogonal Regulatory Circuits for Escherichia coli Based on the gamma-Butyrolactone System of Streptomyces coelicolor.

Journal

ACS Synth Biol 7:1043-1055 (2018)
DOI:10.1021/acssynbio.7b00425

Other DBs

ExplorEnz - The Enzyme Database:

1.3.1.113

IUBMB Enzyme Nomenclature:

1.3.1.113

ExPASy - ENZYME nomenclature database:

1.3.1.113

BRENDA, the Enzyme Database:

1.3.1.113

All links

Chemical substance (5)   
   KEGG COMPOUND (5)   
Chemical reaction (2)   
   KEGG REACTION (1)   
   KEGG RCLASS (1)   
Gene (49)   
   KEGG ORTHOLOGY (1)   
   KEGG GENES (48)   
Protein sequence (8)   
   UniProt (3)   
   SWISS-PROT (1)   
   RefSeq(pep) (4)   
DNA sequence (14)   
   RefSeq(nuc) (14)   
Protein domain (3)   
   InterPro (3)   
All databases (81)   

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