Entry Name 7beta-hydroxy-3-oxochol-24-oyl-CoA 4-desaturase;
Class Oxidoreductases;BRITE hierarchy
Sysname 7beta-hydroxy-3-oxochol-24-oyl-CoA Delta4-oxidoreductase
Reaction(IUBMB) 7beta-hydroxy-3-oxochol-24-oyl-CoA + NAD+ = 7beta-hydroxy-3-oxochol-4-en-24-oyl-CoA + NADH + H+ [RN:
R12111 ]
Reaction(KEGG) Substrate 7beta-hydroxy-3-oxochol-24-oyl-CoA [CPD:
C21911 ];
NAD+ [CPD:
C00003 ]
Product Comment Contains FAD and FMN. The enzyme, characterized from the bacterium Clostridium scindens, participates in the bile acid 7alpha-dehydroxylation pathway. The enzyme catalyses the stereo-specific oxidation of its substrate and has no activity with the 7alpha anomer. cf. EC
1.3.1.115 , 3-oxocholoyl-CoA 4-desaturase.
History EC 1.3.1.116 created 2018
Pathway ec00121 Secondary bile acid biosynthesis
Orthology K15873 7beta-hydroxy-3-oxochol-24-oyl-CoA 4-desaturase
Genes Taxonomy Reference Authors Baron SF, Hylemon PB
Title Expression of the bile acid-inducible NADH:flavin oxidoreductase gene of Eubacterium sp. VPI 12708 in Escherichia coli.
Journal Reference Authors Franklund CV, Baron SF, Hylemon PB
Title Characterization of the baiH gene encoding a bile acid-inducible NADH:flavin oxidoreductase from Eubacterium sp. strain VPI 12708.
Journal Sequence Reference Authors Kang DJ, Ridlon JM, Moore DR 2nd, Barnes S, Hylemon PB
Title Clostridium scindens baiCD and baiH genes encode stereo-specific 7alpha/7beta-hydroxy-3-oxo-delta4-cholenoic acid oxidoreductases.
Journal Sequence Other DBs ExPASy - ENZYME nomenclature database: 1.3.1.116
