Entry
Name
hydroxycinnamoyl-CoA reductase;
MdHCDBR;
hydroxycinnamoyl-CoA double bond reductase
Class
Oxidoreductases;
Acting on the CH-CH group of donors;
With NAD+ or NADP+ as acceptor
BRITE hierarchy
Sysname
dihydro-4-coumaroyl-CoA:NADP+ 2,3-oxidoreductase
Reaction(IUBMB)
(1) dihydro-4-coumaroyl-CoA + NADP+ = trans-4-coumaroyl-CoA + NADPH + H+ [RN:
R12112 ];
(2) dihydroferuloyl-CoA + NADP+ = trans-feruloyl-CoA + NADPH + H+ [RN:
R12113 ]
Reaction(KEGG)
Substrate
dihydro-4-coumaroyl-CoA [CPD:
C21913 ];
NADP+ [CPD:
C00006 ];
dihydroferuloyl-CoA [CPD:
C21914 ]
Product
Comment
Isolated from Malus X domestica (apple). Involved in dihydrochalcone biosynthesis.
History
EC 1.3.1.117 created 2018
Pathway
ec01110 Biosynthesis of secondary metabolites
Reference
Authors
Ibdah M, Berim A, Martens S, Valderrama AL, Palmieri L, Lewinsohn E, Gang DR
Title
Identification and cloning of an NADPH-dependent hydroxycinnamoyl-CoA double bond reductase involved in dihydrochalcone formation in Malusxdomestica Borkh.
Journal
Other DBs
ExPASy - ENZYME nomenclature database: 1.3.1.117