KEGG   ENZYME: 1.3.1.118
Entry
EC 1.3.1.118                Enzyme                                 
Name
meromycolic acid enoyl-[acyl-carrier-protein] reductase;
inhA (gene name)
Class
Oxidoreductases;
Acting on the CH-CH group of donors;
With NAD+ or NADP+ as acceptor
Sysname
meromycolyl-[acyl-carrier protein]:NAD+ oxidoreductase
Reaction(IUBMB)
a meromycolyl-[acyl-carrier protein] + NAD+ = a trans-Delta2-meromycolyl-[acyl-carrier protein] + NADH + H+ [RN:R12236]
Reaction(KEGG)
R12236
Substrate
meromycolyl-[acyl-carrier protein] [CPD:C22023];
NAD+ [CPD:C00003]
Product
trans-Delta2-meromycolyl-[acyl-carrier protein] [CPD:C22022];
NADH [CPD:C00004];
H+ [CPD:C00080]
Comment
InhA is a component of the fatty acid synthase (FAS) II system of Mycobacterium tuberculosis, catalysing an enoyl-[acyl-carrier-protein] reductase step. The enzyme acts on very long and unsaturated fatty acids that form the meromycolic component of mycolic acids. It extends FASI-derived C20 fatty acids to form C60 to C90 mycolic acids. The enzyme, which forms a homotetramer, is the target of the preferred antitubercular drug isoniazid.
History
EC 1.3.1.118 created 2018
Orthology
K11611  meromycolic acid enoyl-[acyl-carrier-protein] reductase
Genes
MXAMXAN_6034
MSDMYSTI_06661
MYMA176_000862
MFBMFUL124B02_34910
CCXCOCOR_06568(inhA)
MFULILAB_16130
MMASMYMAC_005815
SURSTAUR_6711
AGEAA314_08712
AVMJQX13_03355(fabI)
MBDMEBOL_001778
CFUSCYFUS_008453
VINAKJ08_1583
ERZER308_20395(fabI)
EUZDVS28_a2640
MTURv1484(inhA)
MTVRVBD_1484
MTCMT1531(inhA)
MRAMRA_1494(inhA)
MTFTBFG_11513
MTBTBMG_02497
MTKTBSG_02508
MTZTBXG_002476
MTGMRGA327_09305
MTIMRGA423_09315
MTECCDC5079_1380
MTURCFBS_1581(inhA)
MTLCCDC5180_1372
MTOMTCTRI2_1522(inhA)
MTDUDA_1484(inhA)
MTNERDMAN_1652(inhA)
MTJJ112_07970
MTUBMT7199_1516
MTUCJ113_10355
MTUEJ114_07980
MTXM943_07780
MTULTBHG_01463
MTUTHKBT1_1581(inhA)
MTUUHKBT2_1588(inhA)
MTQHKBS1_1585(inhA)
MBOBQ2027_MB1520(inhA)
MBBBCG_1546(inhA)
MBTJTY_1521(inhA)
MBMBCGMEX_1518(inhA)
MBKK60_015910
MBXBCGT_1322
MAFMAF_15070(inhA)
MMICRN08_1663
MCEMCAN_15011(inhA)
MCQBN44_20039(inhA)
MCVBN43_30597(inhA)
MCXBN42_21409(inhA)
MCZBN45_30583(inhA)
MORYMO_001593(inhA)
MLEML1806(inhA)
MLBMLBr01806(inhA)
MPAMAP_1210(inhA)
MAOMAP4_2643
MAVIRC58_13110
MAVURE97_13135
MAVMAV_3294
MITOCO_31450
MIAOCU_31350
MIDMIP_04657
MYOOEM_30640
MCHIAN480_16375
MIROCQ_32080
MMALCKJ54_14395
MLPMLM_1780
MMANMMAN_07200(inhA)
MSAMycsm_02907
MULMUL_1492(inhA)
MMIMMAR_2290(inhA)
MMAEMMARE11_22120(inhA)
MLIMULP_03318(inhA)
MPSEMPSD_23210(inhA)
MSHOMSHO_35340(inhA)
MMCMmcs_2457
MKMMkms_2502
MJLMjls_2494
MMMW7S_15555
MKNMKAN_27240
MYVG155_14295
MYEAB431_13620
MHADB586_13170
MDXBTO20_18315
MSHGMSG_02157(inhA)
MFJMFLOJ_11050(inhA)
MSTOMSTO_12230(inhA)
MSIMMSIM_01960(inhA)
MSAKMSAS_02520(inhA)
MKUI2456_11305(fabI)
MLWMJO58_11470(inhA)
MXEMYXE_28430(inhA)
MNVMNVI_37780(inhA)
MPAGC0J29_12995
MNMMNVM_38210(inhA)
MGORH0P51_12410(fabI)
MCOOMCOO_05340(inhA)
MBAIMB901379_02118(inhA_2)
MSEOMSEO_09350(inhA)
MHEKJMUB5695_02782(inhA_1)
MGAUMGALJ_12570(inhA)
MLJMLAC_13510(inhA)
MBRDMBRA_42300
MSHJMSHI_17260(inhA)
MMAMK3U93_10435(fabI)
MSPGF6B93_09515(fabI)
MOTLTS72_12900(fabI)
MLMMLPF_2285(inhA)
MPAAMKK62_13690(inhA)
MMEHM5I08_12745(inhA)
MKYIWGMT90018_34860(inhA)
MADIA7U43_17325
MWUPT015_04145(inhA)
MSMMSMEG_3151
MSGMSMEI_3070
MSBLJ00_15670
MSNLI99_15675
MSHLI98_15680
MVAMvan_2753
MGIMflv_3657
MSPMspyr1_30030
MCBMycch_2472
MNED174_13485
MYNMyAD_13240
MFTXA26_29600
MPHLMPHLCCUG_02862(inhA_1)
MVQMYVA_2652
MLLB1R94_15730
MRHMycrhN_5280
MTHN4412656_01968(inhA)
MHASMHAS_02110(inhA_1)
MDUMDUV_16010(inhA)
MCHTMCHIJ_41020(inhA)
MDRMDOR_17270(inhA)
MAUUNCTC10437_02605(inhA)
MMAGMMAD_26350(inhA)
MMORMMOR_37220(inhA)
MFXMFAL_06570
MAICMAIC_24400(inhA)
MIJMINS_24620
MALVMALV_10030(inhA)
MTYMTOK_44700(inhA)
MPSCMPSYJ_39370(inhA)
MARZMARA_13230(inhA)
MGADMGAD_11680(inhA)
MHEVMHEL_48950(inhA)
MSARMSAR_43940(inhA)
MANYMANY_10900(inhA)
MAUBMAUB_03720(inhA)
MPOFMPOR_30680(inhA)
MPHUMPHO_09120(inhA)
MMUCC1S78_013650(fabI)
MMATMMAGJ_61610(inhA)
MBOKMBOE_44970(inhA)
MFGK6L26_17720(fabI)
MSEIMSEDJ_38380
MFLVNCTC10271_02817(inhA)
MCEEMCEL_10890(inhA)
MBRML2Z93_002121(inhA)
MMONEWR22_12485(fabI)
MGOAFA91_24105
MHOLK3U96_14075(fabI)
MSENK3U95_12005(fabI)
MPAEK0O64_13420(fabI)
MRFMJO55_12480(inhA)
MDFK0O62_13785(fabI)
MCROMI149_14245(inhA)
MGROFZ046_18515(fabI)
MKRMKOR_10080(inhA)
MPAKMIU77_09440(inhA)
MABMAB_2722c
MMVMYCMA_1487
MABBMASS_2668
MABLMMASJCM_2686
MCHEBB28_13590
MIZBAB75_14740
MSTEMSTE_02663
MSAOMYCSP_12110
MSALDSM43276_02423(inhA_3)
MJDJDM601_2231(inhA)
MTER4434518_02153(inhA)
MMINMMIN_38310(inhA)
MHIBMHIB_16780(inhA)
MHERK3U94_12550(fabI)
MVMMJO54_12495(inhA)
ASDAS9A_1922
NFANFA_34760(inhA)
NFRERS450000_00572(inhA)
NCYNOCYR_2630(inhA)
NBRO3I_027545
NNONONO_c41270(inhA)
NSLBOX37_18745
NSRNS506_04890
NTPCRH09_09465 CRH09_21610
NOZDMB37_06525
NODFOH10_14740(fabI)
NAHF5544_27300(fabI)
NADNCTC11293_04846(inhA)
NWLNWFMUON74_35750
NIEKV110_26815(fabI)
NHUH0264_25410(fabI)
NYALTV02_08880(fabI)
NGPLTT66_26270(fabI)
NSPUIFM12276_21290
NYUD7D52_17975(fabI)
RHARHA1_ro07214
RERRER_30750(fabI)
REYO5Y_14095
REBXU06_14310
RQIC1M55_15335
ROPROP_70020(fabI)
ROAPd630_LPD03964
RPYY013_02755
RBYCEJ39_13435
RHBNY08_1066
RAVAAT18_13400
RFAA3L23_04315(inhA_2)
RHSA3Q41_03952(inhA_2)
RHWBFN03_07665
RHUA3Q40_01680(inhA_1)
RHQIM25_16720
RHODAOT96_25540
RRT4535765_02252(inhA)
RCRNCTC10994_00569(inhA)
RTMG4H71_21230(fabI)
RKOJWS14_37785(fabI)
RGOKYT97_03610(fabI)
ROZCBI38_15655
RPSKJWS13_06440(fabI)
RGORNMQ04_10020(inhA)
RANTRHODO2019_07285(fabI)
RHOPD8W71_16780(fabI)
REQREQ_22500
PDEFP9209_19780(fabI)
WHROG579_02150(inhA)
GBRGbro_2408
GPOGPOL_c23410(inhA)
GORKTR9_2326
GOQACH46_10285
GTABCM27_12395
GOCCXX93_12700
GITC6V83_10720
GRUGCWB2_13270(inhA1)
GOMD7316_00938(inhA)
GAVC5O27_14820
GODGKZ92_12030(fabI)
GAMGII34_12130(fabI)
GPDGII33_11425(fabI)
GJIH1R19_11600(fabI)
GOILK459_21785(fabI)
GHNMVF96_11805(inhA)
GAMIIHQ52_15775(inhA)
GMGNWF22_22135(inhA)
GSIP5P27_09230(inhA)
SPINKV203_10195(fabI)
TPRTpau_2082
TSMASU32_11310
TPULTPB0596_25100
TSDMTP03_23390
SRTSrot_2521
DTMBJL86_1670
DITC3V38_13870
DIZCT688_08065
DPCA6048_08330
DLUA6035_07915
DKNNHB83_07635(inhA)
TOYFO059_08845(fabI)
SCOSCO1814(inhA)
SALBXNR_5008
SMASAVERM_2295(fabI2) SAVERM_6463(fabI1)
SGRSGR_5682
SGBWQO_06910
SFISFUL_1387
SANLKZO11_06595(fabI)
SGRFSGFS_088870
SCYER2B67_29425(fabI)
SCBSCAB_71331
SSXSACTE_1239
SVLStrvi_6897
SHYSHJG_3265
SHOSHJGH_3030
SRCM271_37235
SMALSMALA_1764
SSOII1A49_11980(fabI)
SFASfla_5004
SBHSBI_08182
SVESVEN_1449
SDVBN159_6718(inhA)
SALSSLNWT_4947 SLNWT_6064
STRPF750_1673
SCIB446_09395 B446_27900
SLVSLIV_28650
SGUSGLAU_08040
SVTSVTN_08725
STREGZL_06698
SCWTU94_07660
SLDT261_6340
SLCSL103_00650 SL103_10120
SXISXIM_08040 SXIM_30370
STRMM444_09445
STRCAA958_05120
SAMBSAM23877_1882(inhA)
SPRISPRI_5710
SCZABE83_28890
SCXAS200_34230
SRWTUE45_02288(inhA_1)
STRFASR50_08780
SLEsle_53190(sle_53190)
SRNA4G23_01043(inhA)
SPAVSpa2297_07215 Spa2297_26555
STRTA8713_06640
SCLFBB341_22870
SGSAVL59_11290 AVL59_22200 AVL59_23355 AVL59_35840
STSIA4E84_09150
SKYD0C37_27055(fabI)
SALWCP975_07580(fabI) CP975_22890(fabI)
SGMGCM10017557_64480
SCADDN051_29495
SPHWNFX46_29695(fabI)
SLSSLINC_2077
SNRSNOUR_31185(inhA)
SALUDC74_2313
SALLSAZ_12925
SPLULK06_005965
STRDNI25_30140
SNWBBN63_27435
SAUOBV401_12290
SSIAA7J05_13395 A7J05_27860
SVUB1H20_06075
SPUNBFF78_32330
SGVB1H19_11155
SLAUSLA_1364
SALFSMD44_01946(fabI)
SALJSMD11_5183(fabI)
SLXSLAV_28340(inhA2)
STROSTRMOE7_09990 STRMOE7_19195
SFKKY5_1719c KY5_6749
SNZDC008_07270
SGEDWG14_06601(inhA_4)
SRJSRO_1844 SRO_5654
SLKSLUN_08725
SDXC4B68_31340
SGDELQ87_00785(fabI) ELQ87_30520(fabI)
SQZFQU76_05780(fabI)
SCYAEJ357_10365(fabI)
SASTCD934_26600
SNQCP978_08605(fabI)
STIRDDW44_07500
SKACP970_06910(fabI) CP970_34065(fabI)
SGZC0216_22360
SVNCP980_25715(fabI)
SNKCP967_27260(fabI)
SHAWCEB94_09585 CEB94_22300
SRKFGW37_07670(fabI)
SFICEIZ62_26025(fabI)
SGALCP966_07680(fabI)
SSPODDQ41_05490
SVRCP971_08720(fabI)
SPADDVK44_05100
SFYGFH48_31120(fabI)
SAQUEJC51_12120(fabI) EJC51_43830(fabI)
SGFHEP81_02093(fabI) HEP81_05958
SCAVCVT27_05785
SSEOD0Z67_05985(fabI)
SBYH7H31_03555(fabI) H7H31_28205(fabI)
SRIMCP984_17925(fabI) CP984_31900(fabI)
SSUBCP968_25520(fabI)
SPHVF9278_08945(fabI)
SCINCP977_08145(fabI)
SFUGCNQ36_07755
SPACB1H29_00465 B1H29_28440 B1H29_36595
STSUB7R87_05780
SCHACP983_33715(fabI)
SGXH4W23_09165(fabI)
SCOECP976_10275(fabI) CP976_32245(fabI)
SBATG4Z16_27450(fabI)
SSPBCP982_02960(fabI) CP982_10720(fabI)
SNFJYK04_02485(inhA_2)
SPLACP981_09050(fabI)
SBROGQF42_11855(fabI)
STUIGCM10017668_14080
SATAC5746_09885
SCHFIPT68_08275(fabI)
SHUNDWB77_05910(inhA_2)
SHARHUT13_04585(fabI)
SCYGS1361_09975(inhA)
SFEUIM697_13265(fabI)
SLIAHA039_26885(fabI)
SDWK7C20_08555(fabI) K7C20_18315(fabI)
SVDCP969_10045(fabI)
SCALI6J39_06245(fabI)
SAUHSU9_007030(fabI)
SFBCP974_05410(fabI)
SMOBJ7W19_06960(fabI)
SPRACP972_08110(fabI)
SPEUCGZ69_07760
SROIIAG44_31350(fabI)
SXNIAG42_27770(fabI)
SGJIAG43_06585(fabI) IAG43_25620(fabI)
SHKJ2N69_07400(fabI) J2N69_20420(fabI) J2N69_23920(fabI)
SANUK7396_18400(fabI) K7396_27720(fabI)
STRYEQG64_05865(fabI)
SDDD9753_21060(fabI) D9753_27700(fabI)
SACTDMT42_08250
SMAOCAG99_23700
SGOBtest1122_02165(fabI)
SINEKI385_11665(fabI) KI385_22555(fabI)
SLFJEQ17_35965(fabI)
SDECL3078_10485(fabI)
SAOVG3H79_29390(fabI)
SDURM4V62_32445(fabI)
SYANNRK68_08160(fabI)
SRUGF0345_05110(fabI)
SAKBK1J60_35075(fabI)
STAALDH80_10420(fabI) LDH80_30245(fabI)
SNIGHEK616_16710 HEK616_70990
SVIOHWN34_25285(fabI)
SCAEIHE65_35145(fabI)
STUBMMF93_07110(fabI)
SSPNLXH13_09345(fabI)
SCIRSTRCI_001932(fabI)
SXTKPP03845_102056(inhA_1)
SLONLGI35_12640(fabI)
SDRZNEH16_25035(fabI)
STUDSTRTU_005573(fabI)
STEEF3L20_08760(fabI)
SENGOJ254_09625(fabI) OJ254_18960(fabI)
SGKPET44_08050(fabI)
SANTQR300_32845(fabI)
SYUNMOV08_31195(fabI)
SARGHKX69_27040(fabI)
SJNRI060_33270(fabI)
SCYNN8I84_10080(fabI)
SOVQZH56_28015(fabI)
SFIYF0344_29310(fabI)
SHAUK9S39_33860(fabI)
SKGKJK29_30165(fabI)
SCOAQU709_34175(fabI)
SLAIP8A22_30410(fabI)
SROCRGF97_26950(fabI)
SFPQUY26_31390(fabI)
SCHGNRO40_05865(fabI)
STTNBSL84_07885 BSL84_20915
SINNABB07_29475
STRZOYE22_03425(fabI) OYE22_27480(fabI)
SCTSCAT_1015(inhA)
SCYSCATT_10090
KSKKSE_57090(fabI)
KABB7C62_05895
KAUB6264_03780
KITCFP65_0286 CFP65_5633
KISHUT16_26655(fabI)
STRIC7M71_024260
YIALO772_25500(fabI)
STRHGXP74_26140(fabI) GXP74_30440(fabI)
ABRYNYE86_10455(fabI)
AGLAOIE69_30215(fabI)
LXLKDY119_01609(inhA)
PSICJ4E96_07270(fabI)
AQGHRU87_03895(fabI)
AQKAKACHI_05750
RTNA6122_1628
RRYC1O28_11900
FRPAX769_20845
ACHAchl_4547
BCVBcav_2321
JDEJden_1165
KSEKsed_13510
DNIHX89_07630
DAYFV141_06860(fabI)
DERMH7F30_10555(fabI)
LMOIVV02_14755
YIMJ5M86_07145(fabI)
ALXLVQ62_12190(fabI)
BEIGCM100_17870
XCEXcel_1417
XYLET495_03195(fabI)
XYAET471_12825(fabI)
IVAIsova_1381
IDOI598_0858(inhA_2)
CETB8281_11580
CCEUCBR64_19975
CPRTFIC82_010645(fabI)
SKESked_21770
SANWG7063_06995(fabI)
CFLCfla_0848 Cfla_1687
CFICelf_1715
CGACelgi_1904
CEZCBP52_03825
CELZE5225_09815(fabI)
CEJGC089_10160(fabI)
CELHGXP71_05365(fabI)
CIRALFM56_09885(fabI)
CPALF1D97_10650(fabI)
CELCK5O09_10895(fabI)
CDONKKR89_08245(fabI)
CWANKG103_08500(fabI)
CFENKG102_07555(fabI)
CWNNP075_08615(fabI)
CCHENP064_09335(fabI)
CXIENP048_08395(fabI)
OEKFFI11_012230(fabI)
PSEIGCE65_06025(fabI)
PSEKGCM125_30400
ICAIntca_1723
ARSADJ73_12955
JTEASJ30_08130
JLIEXU32_06225(fabI)
JMEEEW87_007195(fabI)
JAYH7A72_08285(fabI)
JCRO9K63_04990(fabI)
TEHGKE56_04255(fabI)
PHWG7075_06800(fabI)
PEIH9L10_05680(fabI)
TEDU5C87_14305(fabI)
SERJSGUI_0279
SERWFY030_08320(fabI)
ORNDV701_02475
ORZFNH13_11155(fabI)
ORDL0A91_03885(fabI)
OCPNF557_09485(fabI)
BLYA2T55_09530
BLINBLSMQ_2126
BRIFDF13_11380(fabI)
BLUTEW640_03225(fabI)
BCAUI6G59_13050(fabI)
BSPOL1F31_09760(fabI)
DCOSAMEA4475696_1748(inhA)
AUSIPK37_17625(fabI)
GEZFE251_06575(fabI)
GYUFE374_07125(fabI)
HALTIM660_08460(fabI)
RHALLQF10_11130(fabI)
RSUALQF12_07010(fabI)
DEMLGT36_005685(fabI)
DSSGCM25873_10170
PACPPA1532
PAKHMPREF0675_4599
PAVTIA2EST22_07685
PAXTIA2EST36_07670
PAZTIA2EST2_07600
PAWPAZ_c16210(inhA)
PADTIIST44_00660
PCNTIB1ST10_07875
PACCPAC1_08060
PACHPAGK_0647
PACNTIA1EST1_07680
CACNRN83_08130
PRAPALO_03315
PRLBCB70_10760
CGRN4412665_01083(inhA)
CEQUO6R08_06975(fabI)
PFRPFREUD_14860(inhA)
PFRERM25_1407
PACDEGX94_10235(fabI)
PAUSNCTC13651_01795(inhA)
PPCHMPREF9154_1097
ARUBJ5A65_09785(fabI)
PBOPACID_22300
AACIASQ49_10735
ACIJJS278_01256(inhA)
AJIC0Z10_04555
MPHMLP_14730(fabI)
MIKFOE78_17410(fabI)
MICGGJV80_03390(fabI)
TFLRPIT_04435
TFABW733_01645
TESBW730_03545
TEZBKM78_13395
TDFH9L22_03480(fabI)
TLATLA_TLA_02697(inhA)
TEJKDB89_09130(fabI)
RAINRai3103_16520(fabI)
PRVG7070_02480(fabI)
BRTJ4N02_11750(fabI)
PROPQQ658_08650(fabI)
BROObrsh051_04550(fabI)
NCANoca_2572
NDKI601_3386(inhA)
NOYEXE57_01475(fabI)
NOIFCL41_08230(fabI)
NOOFE634_10005(fabI)
NSNEXE58_17975(fabI)
NANOG5V58_10490(fabI)
NMESH9L09_21000(fabI)
NAROCFH99_12925
NPIG7071_15280(fabI)
NAQUENKNEFLB_02471(inhA)
NROK8W59_09210(fabI)
NOQLN652_03775(fabI)
NCQK6T13_08760(fabI)
NPCKUV85_04785(fabI)
NPSKRR39_07650(fabI)
NMARHPC71_10055(fabI)
NFCKG111_08955(fabI)
PSIMKR76_12900
AERAERYTH_15530
MGGMPLG2_2007(inhA)
SGRGL0C25_21005(fabI)
KFLKfla_3713
KQIF1D05_37065(fabI)
KSLOG809_29440(fabI)
TFUTfu_1842
THAONI17_011230(fabI)
TALXFOF52_08780(fabI)
NDANdas_2777 Ndas_4134
NALB005_3507 B005_5318(inhA)
NGVCDO52_17460
NEXNE857_10100(fabI) NE857_20060(fabI)
NECKGD82_10970(fabI) KGD82_20030(fabI)
NAKEKGD83_04570(fabI) KGD83_11675(fabI)
NCGKGD84_11690(fabI)
STRREKD16_14180(inhA)
SNAHOUQ99_06680(fabI) OUQ99_10455(fabI)
SAIUJ4H86_01150(fabI)
TCUTcur_2278
ACTWF7P10_00815(fabI)
AGRAAGRA3207_000536(fabI)
AMAZLUW76_03820(fabI)
ACIROG979_37595(fabI)
SPIQOHA34_01900(fabI)
ACTQOG417_28155(fabI)
SROSros_5937
NOABKM31_06155
NOWGBF35_32365(fabI)
NCXNocox_26320(inhA2)
NGNLCN96_35455(fabI)
NFSOIE67_13050(fabI)
TBITbis_1940
MHAIOHB01_34195(fabI)
FRAFrancci3_1894
FREFranean1_2226
FALFRAAL4522
FSYFsymDg_1766
FRIFraEuI1c_4819
ACEAcel_1152
NMLNamu_2302
NAKEH165_07680(fabI)
NAKAH7F38_17340(fabI)
GOBGobs_2105
BSDBLASA_3113(inhA)
BLAPMVA48_01845(fabI)
MMARMODMU_2062(fabI)
SENSACE_3786(inhA)
SACGFDZ84_31765(fabI)
SVISvir_22330
SACCEYD13_12430(inhA1)
AMDAMED_4940
AMNRAM_25150
AMMAMES_4881
AMZB737_4881
AOIAORI_3781(fabI)
AJAAJAP_20255(inhA)
AMQAMETH_3039(inhA)
AMYCCU254_18080
AMYBBKN51_11375
AABA4R43_11040 A4R43_24795
AMYYYIM_27545(inhA4)
AORISD37_19395
AACDLWP59_15090(fabI)
APRTMUY14_12930(fabI)
AROONQK81_03685(fabI)
ATHML1857_20700(fabI)
ARHDVSH64_13425(fabI)
PDXPsed_3370
PSEAWY02_02980
PSEEFRP1_12610
PSEHXF36_09270
PSEQAD006_18375
PECQAD017_26205
PHHAFB00_25545
PAUTPdca_24080 Pdca_32760
PBROHOP40_24560(fabI)
PPELH6H00_23265(fabI)
APRECNX65_11135
AMIAmir_2181
SESPBN6_31210(inhA)
SSYIEKG83_34400(fabI)
KALKALB_2997
KUTJJ691_04790
KBUQ4V64_11175(fabI)
KPHYAOZ06_20200
LEDBBK82_45535
AHMTL08_10895
ACTIUA75_11620
ACADUA74_11535
AHGAHOG_10870(inhA2)
ACTAC1701_22125
ALOCRK56220
PMADBAY61_17095
SACEGIY23_10485(fabI)
ACTUActkin_03972(inhA_2) Actkin_05747(inhA_4)
CROSN8J89_13975(fabI) N8J89_30555(fabI) N8J89_31235(fabI)
ACTYOG774_05415(fabI)
STPStrop_3024
SAQSare_3250
MAUMicau_4240
MILML5_4063
MICBMicB006_3233
MTUACSH63_03435
MICHFJK98_22710(fabI)
MTEMGCE86_15535(fabI)
MCABHXZ27_21575(fabI) HXZ27_30105
MSAGGCM10017556_04650
VMAVAB18032_25645
MCRAID554_25030(fabI)
VERHUT12_22305(fabI)
MENOJiend_48270
MCHLPVK74_11275(fabI)
MFEUH1D33_26765(fabI)
MPRNQ3V37_16970(fabI)
MHAWRMN56_22160(fabI)
ASEACPL_1918(inhA)
AMSAMIS_16700
ACTNL083_2247 L083_2329(inhA)
AFSAFR_11045
ACTSACWT_1796
AIHAiant_62620
ACTRAsp14428_15090 Asp14428_23280
ACTLL3i22_018850
ASICQ0Z83_070310(fabI)
AOUACTOB_001874(fabI)
PLKCIK06_19320
PLABC6361_25000
PLATC6W10_33195
PFLAPflav_049040
PSUUPsuf_006810
ATLAthai_06340 Athai_33150
ASERAsera_00590 Asera_41460
PRYPrubr_01740
CATICS0771_54740 CS0771_71470
DVCDvina_10550(fabI)
DFUDfulv_09945(fabI)
DROSDrose_09915(fabI)
DAURDaura_09900(fabI)
DMATDmats_10120(fabI)
NHYJQS43_15750(fabI)
CCAZCOUCH_28615(fabI)
CAICaci_2302
SNASnas_2497
NAVJQS30_07095(fabI)
GLYK3N28_15275(fabI)
ACTPB6G06_05275
ACTCCHIBA101_1072
ANEATCC27039_07600
ACTZCWT12_06985
AIRNCTC12972_00999(inhA)
ASLANCTC11923_01677(inhA)
AVCNCTC10951_00535(inhA)
AWEJG540_06055
AMAMHPC72_04465
AREPID810_07040
ACAPMANAM107_21860
AUOR3I39_07615
AEYCDG81_10175
PLANA1s21148_03325
PLAKA1s21155_03155
PLIMPHILAsVB114_03750
PSUFA1sIA56_03060
PVSA1sIA79_02975
PVNA7sIIA15_03880
EKEEK0264_18680(fabI)
JTLM6D93_09495(fabI)
RXYRxyl_0853
RRDRradSPS_0742
RUBGBA63_06600(fabI)
RMARGBA65_13960(fabI)
BSOLFSW04_06040(fabI)
BALADSM104299_00727(inhA_2)
CWOCwoe_4156
PARNNBH00_19565(fabI)
SBAEDSM104329_03271(inhA_1)
TALUJDY09_07805(fabI) JDY09_09230(fabI)
AFOAfer_1232
AYMYM304_19680(fabI)
ATQGH723_08465(fabI)
AQZKSP35_01010(fabI)
IAMHC251_06115(fabI)
IMAPO878_06445(fabI)
DHILH044_08760 LH044_08765(fabI)
TAERGT409_01570
 » show all
Reference
1  [PMID:7599116]
  Authors
Quemard A, Sacchettini JC, Dessen A, Vilcheze C, Bittman R, Jacobs WR Jr, Blanchard JS
  Title
Enzymatic characterization of the target for isoniazid in Mycobacterium tuberculosis.
  Journal
Biochemistry 34:8235-41 (1995)
DOI:10.1021/bi00026a004
Reference
2  [PMID:10336454]
  Authors
Rozwarski DA, Vilcheze C, Sugantino M, Bittman R, Sacchettini JC
  Title
Crystal structure of the Mycobacterium tuberculosis enoyl-ACP reductase, InhA, in complex with NAD+ and a C16 fatty acyl substrate.
  Journal
J Biol Chem 274:15582-9 (1999)
DOI:10.1074/jbc.274.22.15582
  Sequence
[mtu:Rv1484]
Reference
3  [PMID:10708367]
  Authors
Marrakchi H, Laneelle G, Quemard A
  Title
InhA, a target of the antituberculous drug isoniazid, is involved in a mycobacterial fatty acid elongation system, FAS-II.
  Journal
Microbiology 146 ( Pt 2):289-96 (2000)
DOI:10.1099/00221287-146-2-289
Reference
4  [PMID:10869086]
  Authors
Vilcheze C, Morbidoni HR, Weisbrod TR, Iwamoto H, Kuo M, Sacchettini JC, Jacobs WR Jr
  Title
Inactivation of the inhA-encoded fatty acid synthase II (FASII) enoyl-acyl carrier protein reductase induces accumulation of the FASI end products and cell  lysis of Mycobacterium smegmatis.
  Journal
J Bacteriol 182:4059-67 (2000)
DOI:10.1128/JB.182.14.4059-4067.2000
Reference
5  [PMID:18552191]
  Authors
Gurvitz A, Hiltunen JK, Kastaniotis AJ
  Title
Function of heterologous Mycobacterium tuberculosis InhA, a type 2 fatty acid synthase enzyme involved in extending C20 fatty acids to C60-to-C90 mycolic acids, during de novo lipoic acid synthesis in Saccharomyces cerevisiae.
  Journal
Appl Environ Microbiol 74:5078-85 (2008)
DOI:10.1128/AEM.00655-08
  Sequence
[mtu:Rv1484]
Reference
6  [PMID:25891098]
  Authors
Chollet A, Mourey L, Lherbet C, Delbot A, Julien S, Baltas M, Bernadou J, Pratviel G, Maveyraud L, Bernardes-Genisson V
  Title
Crystal structure of the enoyl-ACP reductase of Mycobacterium tuberculosis (InhA) in the apo-form and in complex with the active metabolite of isoniazid pre-formed by a biomimetic approach.
  Journal
J Struct Biol 190:328-37 (2015)
DOI:10.1016/j.jsb.2015.04.008
  Sequence
[mtu:Rv1484]
Other DBs
ExplorEnz - The Enzyme Database: 1.3.1.118
IUBMB Enzyme Nomenclature: 1.3.1.118
ExPASy - ENZYME nomenclature database: 1.3.1.118
BRENDA, the Enzyme Database: 1.3.1.118

DBGET integrated database retrieval system