KEGG   ENZYME: 1.3.1.121
Entry
EC 1.3.1.121                Enzyme                                 
Name
4-amino-4-deoxyprephenate dehydrogenase;
cmlC (gene name);
papC (gene name)
Class
Oxidoreductases;
Acting on the CH-CH group of donors;
With NAD+ or NADP+ as acceptor
Sysname
4-amino-4-deoxyprephenate:NAD+ oxidoreductase (decarboxylating)
Reaction(IUBMB)
4-amino-4-deoxyprephenate + NAD+ = 3-(4-aminophenyl)pyruvate + CO2 + NADH + H+ [RN:R12523]
Reaction(KEGG)
R12523
Substrate
4-amino-4-deoxyprephenate [CPD:C22210];
NAD+ [CPD:C00003]
Product
3-(4-aminophenyl)pyruvate [CPD:C21272];
CO2 [CPD:C00011];
NADH [CPD:C00004];
H+ [CPD:C00080]
Comment
The enzyme, characterized from the bacteria Streptomyces venezuelae and Streptomyces pristinaespiralis, participates in the biosynthesis of the antibiotics chloramphenicol and pristinamycin IA, respectively. cf. EC 1.3.1.12, prephenate dehydrogenase.
History
EC 1.3.1.121 created 2019
Orthology
K24002  4-amino-4-deoxyprephenate dehydrogenase
Genes
PLU: plu3562
PLUM: A4R40_17715
PAY: PAU_01185(papC)
PTT: VY86_14270
PAKH: B0X70_18030
PLUI: CE143_18055
XDO: XDD1_3340(papC)
PFS: PFLU_1770
POI: BOP93_20460
PRH: LT40_00245
PUM: HGP31_16685
PVW: HU752_023340
PSAM: HU731_009630 HU731_024775
PANH: HU763_022805
PZA: HU749_028615
PNB: NK667_19975
BEL: BE61_78230
AGE: AA314_04984
HOH: Hoch_1368
BLH: BaLi_c05410
LGY: T479_11110
MYE: AB431_04565
MDX: BTO20_27410
MCRO: MI149_04845
MIZ: BAB75_16515
CAUI: CAURIS_06030(tyrA)
CAPP: CAPP_05535(tyrA)
RHA: RHA1_ro06105(tryA)
RER: RER_18470
REY: O5Y_08870
REB: XU06_09105
RQI: C1M55_09350
ROP: ROP_61620
ROA: Pd630_LPD02746
RPY: Y013_04230
RBY: CEJ39_15065
RHB: NY08_1915
RAV: AAT18_13965
RFA: A3L23_00261(tyrA_1)
RHS: A3Q41_03153(tyrA_2)
RHW: BFN03_03400
RRZ: CS378_03635
RHU: A3Q40_00455(tyrA_1)
RHQ: IM25_18435
RHOD: AOT96_19710
RRT: 4535765_02685(tyrA_1)
RCR: NCTC10994_00409(tyrA_2)
RTM: G4H71_16465
RKO: JWS14_33270
RGO: KYT97_09330
ROZ: CBI38_20245
RPSK: JWS13_10690
RGOR: NMQ04_11255
RHOP: D8W71_12785
REQ: REQ_23840
GOR: KTR9_2684
GTA: BCM27_14230
GRU: GCWB2_10445(tyrA)
GAV: C5O27_17100
GOD: GKZ92_10150
GHN: MVF96_13970
GAMI: IHQ52_13390
SVE: SVEN_0919
SPRI: SPRI_0305 SPRI_7048
SPLU: LK06_027065
SPUN: BFF78_28825
SSPO: DDQ41_19520
SSEO: D0Z67_01870
SHUN: DWB77_07153(tyrA_3)
SPRA: CP972_04200
SXN: IAG42_36280
RTE: GSU10_09880
NGV: CDO52_20860
MHAI: OHB01_07945
SACG: FDZ84_35425
PBRO: HOP40_07855
APRE: CNX65_18305
SSYI: EKG83_30650
RUB: GBA63_19860
CYC: PCC7424_4586
 » show all
Reference
1  [PMID:9044253]
  Authors
Blanc V, Gil P, Bamas-Jacques N, Lorenzon S, Zagorec M, Schleuniger J, Bisch D, Blanche F, Debussche L, Crouzet J, Thibaut D
  Title
Identification and analysis of genes from Streptomyces pristinaespiralis encoding enzymes involved in the biosynthesis of the 4-dimethylamino-L-phenylalanine precursor of pristinamycin I.
  Journal
Mol Microbiol 23:191-202 (1997)
DOI:10.1046/j.1365-2958.1997.2031574.x
  Sequence
[spri:SPRI_0305 SPRI_7048]
Reference
2  [PMID:11577160]
  Authors
He J, Magarvey N, Piraee M, Vining LC
  Title
The gene cluster for chloramphenicol biosynthesis in Streptomyces venezuelae ISP5230 includes novel shikimate pathway homologues and a monomodular non-ribosomal peptide synthetase gene.
  Journal
Microbiology 147:2817-29 (2001)
DOI:10.1099/00221287-147-10-2817
  Sequence
[sve:SVEN_0919]
Other DBs
ExplorEnz - The Enzyme Database: 1.3.1.121
IUBMB Enzyme Nomenclature: 1.3.1.121
ExPASy - ENZYME nomenclature database: 1.3.1.121
BRENDA, the Enzyme Database: 1.3.1.121

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Chemical substance (6)   
   KEGG COMPOUND (6)   
Chemical reaction (2)   
   KEGG REACTION (1)   
   KEGG RCLASS (1)   
Gene (89)   
   KEGG ORTHOLOGY (1)   
   KEGG GENES (82)   
   KEGG MGENES (6)   
Protein sequence (11)   
   UniProt (2)   
   SWISS-PROT (2)   
   RefSeq(pep) (7)   
DNA sequence (14)   
   RefSeq(nuc) (14)   
Protein domain (6)   
   InterPro (6)   
All databases (128)   

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