Entry |
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Name |
(3S,4R)-3,4-dihydroxycyclohexa-1,5-diene-1,4-dicarboxylate dehydrogenase;
(1R,2S)-dihydroxy-3,5-cyclohexadiene-1,4-dicarboxylate dehydrogenase;
terephthalate 1,2-cis-dihydrodiol dehydrogenase;
cis-4,5-dihydroxycyclohexa-1(6),2-diene-1,4-dicarboxylate:NAD+ oxidoreductase (decarboxylating)
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Class |
Oxidoreductases;
Acting on the CH-CH group of donors;
With NAD+ or NADP+ as acceptor
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Sysname |
(3S,4R)-3,4-dihydroxycyclohexa-1,5-diene-1,4-dicarboxylate:NAD+ oxidoreductase
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Reaction(IUBMB) |
(3S,4R)-3,4-dihydroxycyclohexa-1,5-diene-1,4-dicarboxylate + NAD+ = 3,4-dihydroxybenzoate + CO2 + NADH [RN: R01633]
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Reaction(KEGG) |
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Substrate |
(3S,4R)-3,4-dihydroxycyclohexa-1,5-diene-1,4-dicarboxylate [CPD: C06318];
NAD+ [CPD: C00003]
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Product |
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Comment |
Requires FeII. Involved in the terephthalate degradation pathway in bacteria [2].
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History |
EC 1.3.1.53 created 1999 (EC 1.3.1.61 created 2000, incorporated 2007)
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Pathway |
ec00624 | Polycyclic aromatic hydrocarbon degradation |
ec01120 | Microbial metabolism in diverse environments |
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Orthology |
K18076 | 1,2-dihydroxy-3,5-cyclohexadiene-1,4-dicarboxylate dehydrogenase |
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Genes |
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Reference |
1 |
Authors |
Saller, E., Laue, H.R., Schlafli Oppenberg, H.R. and Cook, A.M. |
Title |
Purification and some properties of (1R,2S)-dihydroxy-3,5-cyclohexadiene-1,4-dicarboxylate dehydrogenase from Comamonas testosteroni T-2. |
Journal |
FEMS Microbiol Lett 130:97-102 (1996) |
Reference |
|
Authors |
Wang YZ, Zhou Y, Zylstra GJ |
Title |
Molecular analysis of isophthalate and terephthalate degradation by Comamonas testosteroni YZW-D. |
Journal |
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Sequence |
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Other DBs |
ExplorEnz - The Enzyme Database: | 1.3.1.53 |
ExPASy - ENZYME nomenclature database: | 1.3.1.53 |
UM-BBD (Biocatalysis/Biodegradation Database): | 1.3.1.53 |
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