KEGG   ENZYME: 1.3.1.79
Entry
EC 1.3.1.79                 Enzyme                                 
Name
arogenate dehydrogenase [NAD(P)+];
arogenic dehydrogenase (ambiguous);
cyclohexadienyl dehydrogenase;
pretyrosine dehydrogenase (ambiguous)
Class
Oxidoreductases;
Acting on the CH-CH group of donors;
With NAD+ or NADP+ as acceptor
Sysname
L-arogenate:NAD(P)+ oxidoreductase (decarboxylating)
Reaction(IUBMB)
L-arogenate + NAD(P)+ = L-tyrosine + NAD(P)H + CO2 [RN:R00732 R00733]
Reaction(KEGG)
R00732 R00733
Substrate
L-arogenate [CPD:C00826];
NAD+ [CPD:C00003];
NADP+ [CPD:C00006]
Product
L-tyrosine [CPD:C00082];
NADH [CPD:C00004];
NADPH [CPD:C00005];
CO2 [CPD:C00011]
Comment
Arogenate dehydrogenases may utilize NAD+ (EC 1.3.1.43), NADP+ (EC 1.3.1.78), or both (EC 1.3.1.79). Enzymes that can utilize both cofactors have been reported from some Proteobacteria, including Burkholderia caryophylli, Burkholderia cepacia, Pseudomonas marginata and Delftia acidovorans.
History
EC 1.3.1.79 created 2005
Pathway
ec00400  Phenylalanine, tyrosine and tryptophan biosynthesis
ec01100  Metabolic pathways
Reference
1  [PMID:7419490]
  Authors
Byng GS, Whitaker RJ, Gherna RL, Jensen RA
  Title
Variable enzymological patterning in tyrosine biosynthesis as a means of determining natural relatedness among the Pseudomonadaceae.
  Journal
J Bacteriol 144:247-57 (1980)
DOI:10.1128/JB.144.1.247-257.1980
Other DBs
ExplorEnz - The Enzyme Database: 1.3.1.79
IUBMB Enzyme Nomenclature: 1.3.1.79
ExPASy - ENZYME nomenclature database: 1.3.1.79
BRENDA, the Enzyme Database: 1.3.1.79
CAS: 64295-75-6

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Pathway (4)   
   KEGG PATHWAY (4)   
Chemical substance (8)   
   KEGG COMPOUND (8)   
Chemical reaction (3)   
   KEGG REACTION (2)   
   KEGG RCLASS (1)   
All databases (15)   

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