Entry |
|
Name |
tRNA-dihydrouridine20a/20b synthase [NAD(P)+];
Dus4p
|
Class |
Oxidoreductases;
Acting on the CH-CH group of donors;
With NAD+ or NADP+ as acceptor
|
Sysname |
tRNA-5,6-dihydrouracil20a/20b:NAD(P)+ oxidoreductase
|
Reaction(IUBMB) |
(1) 5,6-dihydrouracil20a in tRNA + NAD(P)+ = uracil20a in tRNA + NAD(P)H + H+;
(2) 5,6-dihydrouracil20b in tRNA + NAD(P)+ = uracil20b in tRNA + NAD(P)H + H+
|
Substrate |
5,6-dihydrouracil20a in tRNA;
NAD+ [CPD: C00003];
NADP+ [CPD: C00006];
5,6-dihydrouracil20b in tRNA
|
Product |
uracil20a in tRNA;
NADH [CPD: C00004];
NADPH [CPD: C00005];
H+ [CPD: C00080];
uracil20b in tRNA
|
Comment |
A flavoenzyme. The enzyme specifically modifies uracil20a and uracil20b in tRNA.
|
History |
EC 1.3.1.90 created 2011
|
Orthology |
K05545 | tRNA-dihydrouridine synthase 4 |
|
Genes |
OGA: | 100948356(DUS4L) 100955637 |
HGL: | 101699623 101703428(Dus4l) |
SRX: | 107708020(dus4l) 107729134 |
SANH: | 107656270(dus4l) 107658779 |
SGH: | 107584050 107590556(dus4l) |
PPRM: | 120470877(dus4l) 120476746 |
CVG: | 107091918 107095020(dus4l) |
ALIM: | 106515498 106515499 |
SSEN: | 122760199 122773880 |
CCLU: | 121546211 123480981 |
LCM: | 102362301 106706597(DUS4L) |
DSI: | Dsimw501_GD24181(Dsim_GD24181) |
AALB: | 109398884 109429170 |
PPYR: | 116159439 116159440 |
RSAN: | 119372523 119372531 |
PMEO: | 129584688 129598721 129600415 |
CEL: | CELE_C45G9.2(C45G9.2) |
NCS: | NCAS_0J01610(NCAS0J01610) |
NDI: | NDAI_0J02380(NDAI0J02380) |
TPF: | TPHA_0B02120(TPHA0B02120) |
TBL: | TBLA_0A06320(TBLA0A06320) |
TDL: | TDEL_0E01010(TDEL0E01010) |
KAF: | KAFR_0A05830(KAFR0A05830) |
KNG: | KNAG_0B06220(KNAG0B06220) |
CAL: | CAALFM_C500290WA(DUS4) |
NTE: | NEUTE1DRAFT126097(NEUTE1DRAFT_126097) |
BFU: | BCIN_11g02750(Bcdus4) |
CCAC: | CcaHIS019_0105120(DUS4) |
PGR: | PGTG_07394 PGTG_12954 |
» show all
|
Reference |
|
Authors |
Xing F, Hiley SL, Hughes TR, Phizicky EM |
Title |
The specificities of four yeast dihydrouridine synthases for cytoplasmic tRNAs. |
Journal |
|
Sequence |
|
Other DBs |
ExplorEnz - The Enzyme Database: | 1.3.1.90 |
ExPASy - ENZYME nomenclature database: | 1.3.1.90 |
|