KEGG   ENZYME: 1.3.1.90
Entry
EC 1.3.1.90                 Enzyme                                 
Name
tRNA-dihydrouridine20a/20b synthase [NAD(P)+];
Dus4p
Class
Oxidoreductases;
Acting on the CH-CH group of donors;
With NAD+ or NADP+ as acceptor
Sysname
tRNA-5,6-dihydrouracil20a/20b:NAD(P)+ oxidoreductase
Reaction(IUBMB)
(1) 5,6-dihydrouracil20a in tRNA + NAD(P)+ = uracil20a in tRNA + NAD(P)H + H+;
(2) 5,6-dihydrouracil20b in tRNA + NAD(P)+ = uracil20b in tRNA + NAD(P)H + H+
Substrate
5,6-dihydrouracil20a in tRNA;
NAD+ [CPD:C00003];
NADP+ [CPD:C00006];
5,6-dihydrouracil20b in tRNA
Product
uracil20a in tRNA;
NADH [CPD:C00004];
NADPH [CPD:C00005];
H+ [CPD:C00080];
uracil20b in tRNA
Comment
A flavoenzyme. The enzyme specifically modifies uracil20a and uracil20b in tRNA.
History
EC 1.3.1.90 created 2011
Orthology
K05545  tRNA-dihydrouridine synthase 4
Genes
HSA11062(DUS4L)
PTR463652(DUS4L)
PPS100990689(DUS4L)
GGO101126073(DUS4L)
PON100454685(DUS4L)
NLE100584614(DUS4L)
HMH116814230(DUS4L)
MCC699356(DUS4L)
MCF102116116
MTHB126951237
MNI105475314(DUS4L)
CSAB103226714(DUS4L)
CATY105583145
PANU101022289(DUS4L)
TGE112621837(DUS4L)
MLEU105544101(DUS4L)
RRO104677404(DUS4L)
RBB108540475(DUS4L)
TFN117073753(DUS4L)
PTEH111520390(DUS4L)
CANG105516128(DUS4L)
CJC100397658(DUS4L)
SBQ101027485(DUS4L)
CIMI108316805(DUS4L)
CSYR103254409(DUS4L)
MMUR105861047(DUS4L)
LCAT123647722(DUS4L)
PCOQ105815185(DUS4L)
OGA100948356(DUS4L) 100955637
MMU71916(Dus4l)
MCAL110307191(Dus4l)
MPAH110324762(Dus4l)
RNO366593(Dus4l)
MCOC116080842(Dus4l)
ANU117716999(Dus4l)
MUN110565501(Dus4l)
CGE100754261(Dus4l)
MAUA101832289(Dus4l)
PLEU114708443(Dus4l)
MORG121452141(Dus4l)
MFOT126488675
AAMP119818493(Dus4l)
NGI103732175(Dus4l)
HGL101699623 101703428(Dus4l)
CPOC100724297(Dus4l)
CCAN109681354(Dus4l)
DORD105999668(Dus4l)
DSP122111844(Dus4l)
PLOP125346888(Dus4l)
NCAR124990295
MMMA107144546(Dus4l)
OCU100357641
OPI101536303(DUS4L)
TUP102475998(DUS4L)
GVR103586180(DUS4L)
CFA483264(DUS4L)
CLUD112661332(DUS4L)
VVP112908558(DUS4L)
VLG121501738(DUS4L)
NPO129494280(DUS4L)
AML100471327(DUS4L)
UMR103674627(DUS4L)
UAH113258592(DUS4L)
UAR123789401(DUS4L)
ELK111155342
LLV125080365
MPUF101679504(DUS4L)
MNP132016037(DUS4L)
MLK131829245(DUS4L)
NVS122904705(DUS4L)
ORO101385036(DUS4L)
EJU114201707(DUS4L)
ZCA113910941(DUS4L)
MLX118020619(DUS4L)
NSU110574260(DUS4L)
LWW102732323
FCA101095327(DUS4L)
PYU121028883(DUS4L)
PCOO112867001(DUS4L)
PBG122487747(DUS4L)
PVIV125156151(DUS4L)
LRUF124523632
PTG102954378(DUS4L)
PPAD109268068(DUS4L)
PUC125930760
AJU106980677
HHV120241853(DUS4L)
BTA511017(DUS4L)
BOM102275442(DUS4L)
BIU109557388(DUS4L)
BBUB123466052(DUS4L)
BBIS104989702(DUS4L)
CHX102174088(DUS4L)
OAS101104143(DUS4L)
ODA120878181(DUS4L)
CCAD122438313(DUS4L)
SSC100623288(DUS4L)
CFR102523672(DUS4L)
CBAI105063059(DUS4L)
CDK105093038(DUS4L)
VPC107033031(DUS4L)
BACU103006682(DUS4L)
BMUS118900582(DUS4L)
LVE103084319(DUS4L)
OOR101280351(DUS4L)
DLE111184468
PCAD102983313(DUS4L)
PSIU116759220(DUS4L)
NASI112410416(DUS4L)
ECB100050690(DUS4L)
EPZ103558968(DUS4L)
EAI106825192(DUS4L)
MYB102249085(DUS4L)
MYD102752225(DUS4L)
MMYO118665996(DUS4L)
MLF102437667(DUS4L)
PKL118714421(DUS4L)
EFUS103293689(DUS4L)
MNA107526614(DUS4L)
DRO112302998(DUS4L)
SHON119000743(DUS4L)
AJM119053040(DUS4L)
PDIC114508166(DUS4L)
PHAS123811672(DUS4L)
MMF118620022(DUS4L)
PPAM129063531(DUS4L)
HAI109372677(DUS4L)
RFQ117012154(DUS4L)
PALE102883534(DUS4L)
PGIG120591541(DUS4L)
PVP105300329(DUS4L)
RAY107511485(DUS4L)
MJV108396630
TOD119245413(DUS4L)
SARA101538958(DUS4L)
LAV100674137(DUS4L)
TMU101353329
ETF123521545(DUS4L)
DNM101437845(DUS4L)
MDO100010303(DUS4L)
SHR100926240(DUS4L)
AFZ127538337
PCW110207010(DUS4L)
OAA100078188(DUS4L)
GGA769352(DUS4L)
PCOC116232638(DUS4L)
MGP100548170(DUS4L)
TPAI128079720(DUS4L)
LMUT125693608(DUS4L)
NMEL110392380(DUS4L)
APLA101797817(DUS4L)
ACYG106042028(DUS4L)
CATA118249478(DUS4L)
AFUL116492723(DUS4L)
TGU116806612(DUS4L)
LSR110475195(DUS4L)
SCAN103813513(DUS4L)
PMOA120498134(DUS4L)
OTC121336360(DUS4L)
PRUF121357387(DUS4L)
GFR102043964(DUS4L)
FAB101809645(DUS4L)
OMA130248402(DUS4L)
PHI102103781(DUS4L)
PMAJ107204313(DUS4L)
CCAE111922999(DUS4L)
CCW104686922(DUS4L)
CBRC103623428(DUS4L)
ETL114060544(DUS4L)
ZAB102071044(DUS4L)
ACHL103797090(DUS4L)
SVG106848830(DUS4L)
MMEA130572681(DUS4L)
HRT120751580(DUS4L)
FPG101910312(DUS4L)
FCH102050656(DUS4L)
CLV102091172(DUS4L)
EGZ104123778(DUS4L)
NNI104010724(DUS4L)
PCRI104023700(DUS4L)
PLET104614725(DUS4L)
EHS104513307(DUS4L)
PCAO104039313(DUS4L)
ACUN113491397(DUS4L)
TALA104356087(DUS4L)
PADL103920568(DUS4L)
AFOR103906962(DUS4L)
ACHC115341587(DUS4L)
HALD104325366(DUS4L)
HLE104840147(DUS4L)
AGEN126044469
GCL127029589
CCRI104155653(DUS4L)
CSTI104555817(DUS4L)
CMAC104474139(DUS4L)
MUI104534399(DUS4L)
BREG104630223(DUS4L)
FGA104071050(DUS4L)
GSTE104251556(DUS4L)
LDI104345171(DUS4L)
MNB103774923(DUS4L)
OHA104328722(DUS4L)
NNT104400326(DUS4L)
DPUB104308947(DUS4L)
PGUU104458972(DUS4L)
ACAR104518757(DUS4L)
CPEA104387971(DUS4L)
AVIT104279892(DUS4L)
CVF104291602(DUS4L)
RTD128908360(DUS4L)
CUCA104056066(DUS4L)
TEO104383306(DUS4L)
BRHI104487876(DUS4L)
AAM106487761(DUS4L)
AROW112971035(DUS4L)
NPD112953380(DUS4L)
TGT104567981(DUS4L)
DNE112980492(DUS4L)
SCAM104138390(DUS4L)
ASN102379844(DUS4L)
AMJ102575114(DUS4L)
CPOO109315722(DUS4L)
GGN109292134(DUS4L)
PSS102456460(DUS4L)
CMY102930589(DUS4L)
CCAY125630422(DUS4L)
DCC119851192(DUS4L)
CPIC101947398(DUS4L)
TST117875390(DUS4L)
CABI116833371(DUS4L)
MRV120392160(DUS4L)
ACS100554556(dus4l)
ASAO132777224(DUS4L)
PVT110089787(DUS4L)
SUND121931018(DUS4L)
PBI103059158(DUS4L)
PMUR107298716(DUS4L)
CTIG120313014(DUS4L)
TSR106552380(DUS4L)
PGUT117675195(DUS4L)
APRI131202636(DUS4L)
PTEX113436724(DUS4L)
NSS113418357(DUS4L)
VKO123020024(DUS4L)
PMUA114605683(DUS4L)
PRAF128422309(DUS4L)
ZVI118091079
HCG128326354(DUS4L)
GJA107105995(DUS4L)
STOW125435779(DUS4L)
EMC129335712(DUS4L)
XLA734320(dus4l.L)
XTR493309(dus4l)
NPR108797433(DUS4L)
RTEM120931778(DUS4L)
BBUF120982617(DUS4L)
BGAR122927883(DUS4L)
DRE445096(dus4l)
SRX107708020(dus4l) 107729134
SANH107656270(dus4l) 107658779
SGH107584050 107590556(dus4l)
CAUA113059545(dus4l)
PPRM120470877(dus4l) 120476746
CIDE127511555
MASI127435292
TROS130548019(dus4l)
TDW130421473(dus4l)
MANU129432304
IPU108280007
IFU128623530
PHYP113544503(dus4l)
SMEO124400910(dus4l)
TFD113663757(dus4l)
TVC132858890
AMEX103044370(dus4l)
CMAO118812223
EEE113587100(dus4l)
CHAR105896729(dus4l)
TRU101066127(dus4l)
TFS130534892(dus4l)
LCO104922861(dus4l)
NCC104943183(dus4l)
TBEN117470390(dus4l)
CGOB115017885(dus4l)
PGEO117457409
GACU117552181
EMAC134880356(dus4l)
ELY117259959
EFO125889238
PLEP121943421(dus4l)
SLUC116048289
ESP116680237(dus4l)
PFLV114552833(dus4l)
GAT120819754
AFB129106796
CLUM117741557
PSWI130210925(dus4l)
MSAM119883294
SCHU122879575
CUD121523607(dus4l)
ALAT119004609
MZE101485597(dus4l)
ONL100695728(dus4l)
OAU116322939
OLA101172995(dus4l)
OML112149252(dus4l)
CSAI133441704(dus4l)
XMA102229408(dus4l)
XCO114161344(dus4l)
XHE116707953(dus4l)
PRET103474523(dus4l)
PFOR103145573(dus4l)
PLAI106948041(dus4l)
PMEI106904260(dus4l)
GAF122832065(dus4l)
PPRL129358853(dus4l)
CVG107091918 107095020(dus4l)
CTUL119776614(dus4l)
GMU124884675(dus4l)
NFU107380409(dus4l)
KMR108246510
ALIM106515498 106515499
NWH119410575(dus4l)
AOCE111580677(dus4l)
CSEM103378506(dus4l)
POV109630094(dus4l)
SSEN122760199 122773880
HHIP117773417
HSP118106245(dus4l)
SMAU118298920
LCF108888402
SDU111224099(dus4l)
SLAL111661104(dus4l)
XGL120792388
HCQ109525446(dus4l)
SSCV125972562
SBIA133504947(dus4l)
PEE133405349(dus4l)
PTAO133482369(dus4l)
BPEC110174434(dus4l)
MALB109960245(dus4l)
BSPL114867999
SJO128360670
SASA106576118(dus4l)
STRU115179994(dus4l)
OTW112216884
OMY110490283
OGO123995501(dus4l)
ONE115106974
OKI109864419
OKE118366237(dus4l)
SALP111951476(dus4l)
SNH120031806(dus4l)
CCLU121546211 123480981
ELS105027510(dus4l)
SFM108918731(dus4l)
PKI111857475(dus4l)
LOC102688983(dus4l)
PSPA121319799(dus4l)
ARUT117414473(dus4l)
PSEX120533999(dus4l)
LCM102362301 106706597(DUS4L)
CMK103189348(dus4l)
RTP109932616(dus4l)
CPLA122561681(dus4l)
HOC132826743(dus4l)
LERI129707743(dus4l)
PMRN116956128
LRJ133357952
BFO118432392
BBEL109476047
CIN100186307
SCLV120340796
SPU581098
LPIC129256446
APLC110981916
AJC117119566
SKO100374793
DMEDmel_CG10495(Dus4)
DER6549380
DSE6614640
DSIDsimw501_GD24181(Dsim_GD24181)
DYADyak_GE13230
DAN6497518
DSR110181433
DPO4817962
DPE6593812
DMN108162081
DWI6642387
DGR6562613
DMODmoj_GI17600
DAZ108611593
DNV115563064
DHE111603893
DVI6634120
CCAT101454313
BOD106615456
BDR105232441
RZE108366421
AOQ129249304
TDA119686093
MDE101896430
SCAC106088212
LCQ111685438
LSQ119600962
GFS119633353
ECOE129953356
CLON129606852
HIS119660732
AGA1273173
ACOZ120961740
AARA120898787
AMER121589564
ASTE118504306
AFUN125764335
AMOU128310121
AALI118461920
AAG5567166
AALB109398884 109429170
CQUCpipJ_CPIJ014394
CPII120422093
CNS116340981
BCOO119082624
ACER107998015
ADR102676849
AFLR100868928
FVI122527695
MGEN117219572
SOC105196190
MPHA105837593
AEC105148982
ACEP105622039
PBAR105428803
VEM105565259
HST105181894
DQU106748214
CFO105257987
LHU105674473
PGC109856204
OBO105283351
PCF106784690
PFUC122521425
VPS122626860
VCRB124432636
VVE124947374
NVI100115015
CSOL105365352
TPRE106658875
LHT122501511
LBD127278800
MDL103569058
CGLO123265822
FAS105271168
AGIF122850702
CINS118068298
VCAN122418954
DSM124416032
NPT124222764
NFB124180395
NLO107227533
NVG124310095
AROA105692505
TCA663296
DPA109539703
SOY115876183
AGRG126734095
ATD109595591
CSET123308735
AGB108914100
LDC111509137
NVL108565288
APLN108738335
PPYR116159439 116159440
OTU111423908
BMOR101745883
BMAN114244253
MSEX115444665
DPLKGM_207932
BANY112057703
MJU123867001
NIQ126768296
VCD124530649
MCIX123654324
PMAC106714768
PPOT106105316
PXU106125032
PRAP110994669
PBX123706744
PNAP125056164
ZCE119831147 119831153
CCRC123692924
LSIN126977063
HAW110384187
HZE124630778
TNL113495205
SLIU111349463
OFU114354342
PXY105393609
PGW126366748
CFEL113377864
CCRN123305069
API100167730
DNX107169807
AGS114131714
RMD113553609
ACOO126847898
DVT126905218
BTAB109039563
DCI113469377
CLEC106673554
HHAL106692918
NLU111044590
HVI124368557
MQU128994931
PHUPhum_PHUM259550
FOC113213200
TPAL117653788
ZNE110831351
CSEC111866540
SGRE126299377
BROR134538116
IEL124167036
FCD110854049
DPXDAPPUDRAFT_304174
DMK116925845
DPZ124312709
PVM113806313
PCHN125039299
PMOO119586590
HAME121879923
PCLA123757063
CQD128692677
PTRU123507354
ESN126981064
HAZT108678274
EAF111715844
LSM121119327
TCF131877395
PPOI119112142
DSV119466391
RSAN119372523 119372531
VDE111255310
VJA111261777
PTEP107439076
ABRU129959971
UDV129231600
SDM118184851
LPOL106458996
PMEO129584688 129598721 129600415
CELCELE_C45G9.2(C45G9.2)
CBRCBG_23028
CRQGCK72_008314
NAINECAME_15678
BMYBM_BM2781(Bm2781)
LOALOAG_06685
TSPTsp_09890
HROHELRODRAFT_107587
LGILOTGIDRAFT_134818
PVUL126827711
PCAN112572810
BGT106079329
GAE121368428
HRF124152977
HRJ124286081
CRG105328781
CVN111107450 111109651
CANU128161789
OED125656217
MYI110461696
PMAX117330874
MCAF127705855
MMER123529821
RPHI132721765
DPOL127865101
OBI106880305
OSN115210923
LAK106165562 106171124
SMMSmp_026700
EGLEGR_04659
NVE5519090
EPA110236760
ATEN116289401
ADF107339754
AMIL114965910
PDAM113671963
SPIS111324254
DGT114516139
XEN124444037
HMG100200707
HSY130625349
TADTRIADDRAFT_52208
AQU100640737
SCEYLR405W(DUS4)
SEUBDI49_3903
SPAOSPAR_L04120
AGOAGOS_AER075W
ERCEcym_3249
KLAKLLA0_B02959g
KMXKLMA_40453(DUS4)
LTHKLTH0D14806g
VPOKpol_1055p69
ZROZYRO0B12826g
CGRCAGL0M09911g
NCSNCAS_0J01610(NCAS0J01610)
NDINDAI_0J02380(NDAI0J02380)
TPFTPHA_0B02120(TPHA0B02120)
TBLTBLA_0A06320(TBLA0A06320)
TGBHG536_0E01900
TDLTDEL_0E01010(TDEL0E01010)
KAFKAFR_0A05830(KAFR0A05830)
KNGKNAG_0B06220(KNAG0B06220)
ZMKHG535_0B06640
PPAPAS_chr4_0179
DHADEHA2B07942g
PICPICST_33532(DUS4)
PGUPGUG_02182
SPAASPAPADRAFT_138409
LELPVL30_004523(DUS4)
CALCAALFM_C500290WA(DUS4)
CTPCTRG_05251
COTCORT_0E06390
CDUCD36_50320
CTENCANTEDRAFT_98387
YLIYALI0E26059g
CLUCLUG_03413
CLUSA9F13_01g07722
CAURCJI96_0001338
SLBAWJ20_2222(DUS4)
PKZC5L36_0A03950
BNNFOA43_001811
BBRXBRETT_004692
OPAHPODL_00597
SLUDSCDLUD_004276
NCRNCU03195
NTENEUTE1DRAFT126097(NEUTE1DRAFT_126097)
SMPSMAC_02915
PANPODANSg5611
PBELQC761_109140(DUS4)
PPSDQC762_109140(DUS4)
PPSPQC763_109140(DUS4)
PPSAQC764_109140(DUS4)
TTTTHITE_2056478
MTMMYCTH_2295183
CTHRCTHT_0054810
MGRMGG_01257
PPEIPpBr36_00764
PGRIPgNI_04169
TMNUCRPA7_7697
FGRFGSG_01258
FPUFPSE_00434
FPOAFPOAC1_001351
FVNFVRRES_01545
FVRFVEG_01388
FOXFOXG_00129
NHENECHADRAFT_74526
FFCNCS54_00061300
FMUJ7337_000633
TRETRIREDRAFT_71649
TRRM419DRAFT_25310
MAWMAC_00559
MAJMAA_07250
PCHMVFPPC_09203
CMTCCM_06932
AMUSLMH87_011651
PLJVFPFJ_03361
PTKZJDV02_001687(DUS4)
VALVDBG_04894
VDAVDAG_04437
CFJCFIO01_08614
CLUPCLUP02_05479
CHIGCH63R_00612
ELAUCREL1_1957
PFYPFICI_00230
SSLSS1G_06500
BFUBCIN_11g02750(Bcdus4)
MBEMBM_09488
PSCOLY89DRAFT_712024
GLZGLAREA_11645
ZTRMYCGRDRAFT_37404
PFJMYCFIDRAFT_83236
FFUCLAFUR5_10556
CBETCB0940_06690
BCOMBAUCODRAFT_27019
TMLGSTUM_00001458001
SPOSPCC777.15
SOMSOMG_04789(dus4)
CNECNA02240
CNBCNBA2100
CNGCNAG_00234
CGICGB_B2580W
CDEUCNBG_0333
TMSTREMEDRAFT_68173
TASAA1Q1_05803
CCACCcaHIS019_0105120(DUS4)
ADLAURDEDRAFT_185766
FMEFOMMEDRAFT_105200
RSXRhiXN_03005
WSEWALSEDRAFT_41734
WICJ056_003801
UMAUMAG_02414
PFPPFL1_01589
SGRAEX895_004839
MGLMGL_2875
MRTMRET_3471
MSYMMSY001_0357
PGRPGTG_07394 PGTG_12954
PTRCPtA15_11A186
PSTRPst134EA_017763
MLRMELLADRAFT_93719
MBRMONBRDRAFT_31519
SREPTSG_11749
DDIDDB_G0291360(dus4l)
DPPDICPUDRAFT_151810
DFADFA_07790(dus4l)
PFAPF3D7_1408900
PFHPFHG_03486
PREIPRSY57_1408200
PGABPGSY75_1408900
PYOPY17X_1036000
PCBPCHAS_1034400
PBEPBANKA_1033600
PVVPVVCY_1003900
PKNPKNH_1349500
PVXPVX_086005
PCYPCYB_134790
PMALPMUG01_13049600
PRELPRELSG_1342200
TANTA21490
TPVTP01_0269
TOTTOT_010001229
BEQBEWA_031780
BBOBBOV_IV004780
BBIGBBBOND_0210190
CPVcgd1_3440
CHOChro.10384
GTTGUITHDRAFT_66170
NGRNAEGRDRAFT_70940
 » show all
Reference
1  [PMID:14970222]
  Authors
Xing F, Hiley SL, Hughes TR, Phizicky EM
  Title
The specificities of four yeast dihydrouridine synthases for cytoplasmic tRNAs.
  Journal
J Biol Chem 279:17850-60 (2004)
DOI:10.1074/jbc.M401221200
  Sequence
[sce:YLR405W]
Other DBs
ExplorEnz - The Enzyme Database: 1.3.1.90
IUBMB Enzyme Nomenclature: 1.3.1.90
ExPASy - ENZYME nomenclature database: 1.3.1.90
BRENDA, the Enzyme Database: 1.3.1.90

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