KEGG ENZYME: 1.3.1.95

ENZYME: 1.3.1.95

Entry

EC 1.3.1.95                 Enzyme

Name

acrylyl-CoA reductase (NADH)

Class

Oxidoreductases;
Acting on the CH-CH group of donors;
With NAD+ or NADP+ as acceptor

Sysname

propanoyl-CoA:NAD+ oxidoreductase

Reaction(IUBMB)

propanoyl-CoA + NAD+ = acryloyl-CoA + NADH + H+ [RN:R10161]

Reaction(KEGG)

R10161

Substrate

propanoyl-CoA [CPD:C00100];
NAD+ [CPD:C00003]

Product

acryloyl-CoA [CPD:C00894];
NADH [CPD:C00004];
H+ [CPD:C00080]

Comment

Contains FAD. The reaction is catalysed in the opposite direction to that shown. The enzyme from the bacterium Clostridium propionicum is a complex that includes an electron-transfer flavoprotein (ETF). The ETF is reduced by NADH and transfers the electrons to the active site. Catalyses a step in a pathway for L-alanine fermentation to propanoate [1]. cf. EC 1.3.1.84, acrylyl-CoA reductase (NADPH).

History

EC 1.3.1.95 created 2012

Pathway

ec00640

Propanoate metabolism

ec01100

Metabolic pathways

Orthology

K20143

acrylyl-CoA reductase (NADH)

Genes

CPRO:

CPRO_21630(acrC)

ANV:	RBQ60_06035

TEM:	JW646_01980

TGC:	L0P85_06205

TMY:	TEMA_03220(acrC)

PEB:	O0R46_01435

MSEA:

METESE_33210

Reference

1 [PMID:12603323]

Authors

Hetzel M, Brock M, Selmer T, Pierik AJ, Golding BT, Buckel W

Title

Acryloyl-CoA reductase from Clostridium propionicum. An enzyme complex of propionyl-CoA dehydrogenase and electron-transferring flavoprotein.

Journal

Eur J Biochem 270:902-10 (2003)
DOI:10.1046/j.1432-1033.2003.03450.x

Reference

2 [PMID:22810300]

Authors

Kandasamy V, Vaidyanathan H, Djurdjevic I, Jayamani E, Ramachandran KB, Buckel W, Jayaraman G, Ramalingam S

Title

Engineering Escherichia coli with acrylate pathway genes for propionic acid synthesis and its impact on mixed-acid fermentation.

Journal

Appl Microbiol Biotechnol 97:1191-200 (2013)
DOI:10.1007/s00253-012-4274-y

Sequence

[ag:AEM62998]

Other DBs

ExplorEnz - The Enzyme Database:

1.3.1.95

IUBMB Enzyme Nomenclature:

1.3.1.95

ExPASy - ENZYME nomenclature database:

1.3.1.95

BRENDA, the Enzyme Database:

1.3.1.95

DBGET integrated database retrieval system