KEGG ENZYME: 1.3.3.13

ENZYME: 1.3.3.13

Entry

EC 1.3.3.13                 Enzyme

Name

albonoursin synthase;
cyclo(dipeptide):oxygen oxidoreductase;
cyclic dipeptide oxidase;
AlbA

Class

Oxidoreductases;
Acting on the CH-CH group of donors;
With oxygen as acceptor

Sysname

cyclo(L-leucyl-L-phenylalanyl):oxygen oxidoreductase

Reaction(IUBMB)

cyclo(L-leucyl-L-phenylalanyl) + 2 O2 = albonoursin + 2 H2O2 (overall reaction) [RN:R10329];
(1a) cyclo(L-leucyl-L-phenylalanyl) + O2 = cyclo[(Z)-alpha,beta-didehydrophenylalanyl-L-leucyl] + H2O2 [RN:R10327];
(1b) cyclo[(Z)-alpha,beta-didehydrophenylalanyl-L-leucyl] + O2 = albonoursin + H2O2 [RN:R10328]

Reaction(KEGG)

R10327 R10328 R10329

Substrate

cyclo(L-leucyl-L-phenylalanyl) [CPD:C20519];
O2 [CPD:C00007];
cyclo[(Z)-alpha,beta-didehydrophenylalanyl-L-leucyl] [CPD:C20521]

Product

albonoursin [CPD:C20520];
H2O2 [CPD:C00027];
cyclo[(Z)-alpha,beta-didehydrophenylalanyl-L-leucyl] [CPD:C20521]

Comment

A flavoprotein from the bacterium Streptomyces noursei. The enzyme can also oxidize several other cyclo dipeptides, the best being cyclo(L-tryptophyl-L-tryptophyl) and cyclo(L-phenylalanyl-L-phenylalanyl) [1,2].

History

EC 1.3.3.13 created 2013

Orthology

K21375

albonoursin synthase

Genes

STRE:

GZL_03261

SNR:	SNOUR_14230

SALU:

DC74_8070

SALL:

SAZ_41675

SHK:	J2N69_29180

SYUN:

MOV08_14060

NAKE:

KGD83_19825

Reference

1 [PMID:11248691]

Authors

Gondry M, Lautru S, Fusai G, Meunier G, Menez A, Genet R

Title

Cyclic dipeptide oxidase from Streptomyces noursei. Isolation, purification and partial characterization of a novel, amino acyl alpha,beta-dehydrogenase.

Journal

Eur J Biochem 268:1712-21 (2001)
DOI:10.1046/j.1432-1327.2001.02038.x

Reference

2 [PMID:12498889]

Authors

Lautru S, Gondry M, Genet R, Pernodet JL

Title

The albonoursin gene Cluster of S noursei biosynthesis of diketopiperazine metabolites independent of nonribosomal peptide synthetases.

Journal

Chem Biol 9:1355-64 (2002)
DOI:10.1016/S1074-5521(02)00285-5

Sequence

[ag:AAN07907]

Other DBs

ExplorEnz - The Enzyme Database:

1.3.3.13

IUBMB Enzyme Nomenclature:

1.3.3.13

ExPASy - ENZYME nomenclature database:

1.3.3.13

BRENDA, the Enzyme Database:

1.3.3.13

All links

Chemical substance (5)   
   KEGG COMPOUND (5)   
Chemical reaction (6)   
   KEGG REACTION (3)   
   KEGG RCLASS (3)   
Gene (9)   
   KEGG ORTHOLOGY (1)   
   KEGG GENES (8)   
Protein sequence (64)   
   UniProt (63)   
   SWISS-PROT (1)   
DNA sequence (29)   
   GenBank (15)   
   EMBL (14)   
Protein domain (2)   
   InterPro (2)   
All databases (115)   

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