KEGG ENZYME: 1.3.8.12

ENZYME: 1.3.8.12

Entry

EC 1.3.8.12                 Enzyme

Name

(2S)-methylsuccinyl-CoA dehydrogenase;
Mcd

Class

Oxidoreductases;
Acting on the CH-CH group of donors;
With a flavin as acceptor

Sysname

(2S)-methylsuccinyl-CoA:electron-transfer flavoprotein oxidoreductase

Reaction(IUBMB)

(2S)-methylsuccinyl-CoA + electron-transfer flavoprotein = 2-methylfumaryl-CoA + reduced electron-transfer flavoprotein [RN:R09293]

Reaction(KEGG)

R09293

Substrate

(2S)-methylsuccinyl-CoA [CPD:C18324];
electron-transfer flavoprotein [CPD:C04253]

Product

2-methylfumaryl-CoA [CPD:C06028];
reduced electron-transfer flavoprotein [CPD:C04570]

Comment

The enzyme, characterized from the bacterium Rhodobacter sphaeroides, is involved in the ethylmalonyl-CoA pathway for acetyl-CoA assimilation. The enzyme contains FAD.

History

EC 1.3.8.12 created 2015

Pathway

ec00630

Glyoxylate and dicarboxylate metabolism

ec01100

Metabolic pathways

ec01120

Microbial metabolism in diverse environments

Orthology

K14448

(2S)-methylsuccinyl-CoA dehydrogenase

Genes

PSET:

THL1_4233

MARI:

ACP86_19405

MANP:

EHN06_02515

KAK:	Kalk_01775

ALKM:

NKI27_11390

ASEM:

NNL22_07745

STAW:

NCG89_13780

GAI:	IMCC3135_16910(mcd)

OME:	OLMES_2174

GBI:	PG2T_00815

GPB:	HDN1F_16010

TVL:	FAZ95_10120

ADN:	Alide_3214

ADK:	Alide2_1233

HYB:

Q5W_20085

XYK:	GT347_20760

APP:	CAP2UW1_2497

MESW:

A9K65_031175

PLA:

Plav_1613

PMOB:

HG718_00340

KMN:	HW532_17100

PECT:

BN1012_Phect1028

RBS:	RHODOSMS8_02653(mcd)

EMX:	FKV68_30905

RFV:	RFYW14_04019

BOP:	AXW83_03455

BOS:	BSY19_2144

BVV:	BHK69_16360

BOI:	BLM15_14085

BOF:	FQV39_08880

BVES:

QO058_23685

XAU:

Xaut_0310

XDI:	EZH22_06665

AZC:

AZC_4648

APOL:

K9D25_22030

MEA:	Mex_1p2223(ibd2)

MDI:	METDI3005(msd)

MEX:

Mext_2228

MCH:

Mchl_2504

MPO:

Mpop_2186

MZA:	B2G69_18750

MRD:	Mrad2831_4351

MET:

M446_4575

MNO:

Mnod_4511

MOR:

MOC_5019

META:

Y590_10710

MAQU:

Maq22A_c07055(ibd2)

MPHY:

MCBMB27_03874

MEE:	DA075_26015

METD:

C0214_12585

METX:

A3862_09600

METS:

DK389_01585

METI:

DK427_01745

MMES:

MMSR116_04950

MTEA:

DK419_07360

MIND:

mvi_48210

MOG:	MMB17_24190

MTAD:

M6G65_24885

RHJ:	HZY79_04285

CDQ:	BOQ54_02770

HDN:

Hden_0214

HDT:	HYPDE_23628

HMC:	HYPMC_0100(msd)

HNI:	W911_17390

RVA:

Rvan_2966

RLAC:

QMO75_11160

FIL:	BN1229_v1_1376

FIY:	BN1229_v1_1375

RHZ:	RHPLAN_11820

MCG:

GL4_3336

METG:

HT051_03010

BVR:

BVIR_182

BLAG:

BLTE_34660

MSC:

BN69_1942

MBRY:

B1812_14845

MROS:

EHO51_15530

MHEY:

H2LOC_017850

MPAR:

F7D14_06305

MIWA:

SS37A_03200

MTW:	CQW49_16350

MECQ:

MSC49_02720

CMET:

K6K41_15570

PLEO:

OHA_1_02835(ibd2)

HDI:	HDIA_3966(mmgC_1)

BRN:	D1F64_21120

PSIN:

CAK95_11900

NOH:	G5V57_10340

RBM:

TEF_03545

PSF:

PSE_0035

PPHR:

APZ00_08230

LAP:	ACP90_03340

LABR:

CHH27_17300

LABP:

FJ695_06860

LABT:

FIU93_08975(mmgC1)

LAGG:

B0E33_14815

RPOP:

K1718_04170

SIW:	GH266_11160

PHR:	C6569_20730

PSTG:

E8M01_09815

PAQT:

E8L99_03210

ACUT:

MRB58_00795

CCR:

CC_3087

CCS:	CCNA_03184

CAK:

Caul_1059

CSE:

Cseg_3655

CHQ:	AQ619_02845

CMB:	CSW64_19025

CFH:	C1707_03575

CAUF:

CSW63_19600

PZU:

PHZ_c3145

PHB:	HYN04_01310

TSV:	DSM104635_01226(mmgC_3)

SIL:

SPO0693

SIT:	TM1040_2444

RUA:	D1823_10490

RUT:	FIU92_02785(mmgC1)

RCON:

K3740_04120

JAN:

Jann_0530

RDE:	RD1_1372(ibd2)

RLI:	RLO149_c034140

RPON:

G3256_02665

DSH:	Dshi_0204(mmgC)

PGA:	PGA1_c01110

PGL:	PGA2_c29780

PGD:

Gal_00245

PHP:	PhaeoP97_00338

PPIC:

PhaeoP14_02942

PHQ:	D1820_10540

OAT:	OAN307_c03080

OAR:	OA238_c02240

OTM:	OSB_02210(mmgC_1)

OCT:	FTO60_01335

LMD:	METH_00815

LEJ:	ETW24_00805

LAQU:

R2C4_16280

LCAE:

K3721_00960

RED:	roselon_01508

CID:

P73_0612

CMAR:

IMCC12053_1518

CEH:	CEW89_14850

MALG:

MALG_03387

CON:	TQ29_01745

YPAC:

CEW88_03080

YAN:	AYJ57_10165

TPRO:

Ga0080559_TMP1223

PABY:

Ga0080574_TMP1791

SUAM:

BOO69_01730

SULZ:

C1J03_02875

SULI:

C1J05_02105

SULD:

B5M07_15630

SPOT:

G6548_14190

SMED:

JNX03_10970

SINL:

DSM14862_03067(mcd)

SFAV:

PL335_14690

SUAL:

KDD17_12410

SDUB:

R1T39_09500

SPSE:

SULPSESMR1_02661(mcd)

TOM:	BWR18_13585

RMM:	ROSMUCSMR3_01322(mcd)

ROK:	RAK1035_0274

RID:	RIdsm_00183(mmgC_3)

ROM:	EI983_14390

ROH:	FIU89_16755(mmgC5)

RPEL:

N7U68_07475

AHT:	ANTHELSMS3_01950

SAGU:

CDO87_13230

THAA:

CFI11_02130

OCD:	FHY55_18290

ROT:	FIV09_15425(mmgC3)

RMH:	LVO79_13390

MALU:

KU6B_08810

TGL:	HFZ77_13930

TMD:	KUV46_07595

HAT:	RC74_04475

PALX:

GQA70_15605

LSAL:

KBK07_00695

LALG:

LentiSH36_01963

TRY:	QF118_05535

MARU:

FIU81_13010(mmgC4)

RMAI:

MACH21_30710

RSP:

RSP_1679

RSH:	Rsph17029_0312

RSQ:	Rsph17025_2567

RSK:	RSKD131_3079

CAZT:

LV780_11785

RCP:	RCAP_rcc03306

RHP:	LPB142_14090

RBL:	B6K69_12755

FYT:	QF092_15420

PDE:

Pden_2840

PAMI:

JCM7686_0656

PYE:	A6J80_04750

PCON:

B0A89_08760

PZH:	CX676_16780

PARO:

CUV01_04620

PAMN:

JCM7685_1082

PARR:

EOJ32_04100

PAAK:

FIU66_02420

PKD:	F8A10_17805

PPAN:

ESD82_07180

PLIA:

E4191_01960

PSAN:

HGN31_12625

PMAU:

CP157_02762(mcd)

PMEH:

JWJ88_13515 JWJ88_18485

PSEW:

JHW44_02365

PSAP:

JHX88_05830

PFIS:

JHX87_14200

PAEX:

JHW48_13610

PSTL:

JHW45_03185

PALP:

JHW40_06105

PVER:

E3U25_10380 E3U25_12550

PFEO:

E3U26_17965

PTP:	RCA23_c05210

RSU:

NHU_01021

RHM:	B5V46_13600

RHC:

RGUI_2888

RMB:	K529_011675

TSCO:

R1T40_19110

DAA:	AKL17_0387

DON:	BSK21_01045

RBZ:	B9057_00825

TEC:	AKL02_018800

LVS:	LOKVESSMR4R_00199(mcd)

RBG:	BG454_04115

GEH:	HYN69_01605

GFU:	KM031_11680

TAW:	EI545_08280

SALO:

EF888_00405

SEDI:

EBB79_01115

PPSO:

QPJ95_06005

BOO:	E2K80_17425

PSEB:

EOK75_15210

PPRU:

FDP22_10630

PAED:

G5B38_16425

MON:	G8E03_13660

PAMO:

BAR1_16245

POZ:	I0K15_01150

PALW:

PSAL_022590(mcd)

PSHQ:

F3W81_12655

PGV:	SL003B_0448

CACT:

HZ995_08795

THAS:

C6Y53_12405

HDH:	G5B40_02075

CMAG:

CBW24_14615

GCE:	KYE46_00120

NSM:	JO391_18650

ACRO:

K3J57_01055

SINR:

O5O51_02550

AALK:

LGT41_0000495

AMYL:

QBD29_15230

AMAQ:

GO499_18380

RHOC:

QTA57_07100

PBAE:

P8S53_11360

FAQ:	G5B39_04545

RBX:	I3V23_10315

HNE:

HNE_3379

HBA:

Hbal_0249

CBOT:

ATE48_04215

HBC:	AEM38_11365

NAR:

Saro_3795

NPP:	PP1Y_AT31373 PP1Y_AT31999

NPN:	JI59_17585

NOT:	C7W88_21090

NOR:	FA702_12980

NGF:	FRF71_05160

NOG:	GKE62_14150

SAL:

Sala_2897

SPHK:

SKP52_19810

SPHP:

LH20_06640

SMAG:

AN936_15840

SMAZ:

LH19_02450

STER:

AOA14_14405

SGI:	SGRAN_3010(ibd2)

SPHQ:

BWQ93_00925

SPHO:

C3E99_10420

SPHX:

E5675_00380

SINA:

KNJ79_05715

SPHU:

SPPYR_1404 SPPYR_3581

SPHD:

HY78_18255

SPHA:

D3Y57_03955

SLAN:

GV829_02840

SPAP:

H3Z74_06280

SRAD:

LLW23_12455

SCH:	Sphch_1000

SYB:	TZ53_15780

SPHB:

EP837_00036

SPHT:

K426_13845

SYA:	A6768_05870

SCLO:

SCLO_1006500

SUFL:

FIL70_02615 FIL70_14440

SBAR:

H5V43_02925

CIJ:	WG74_11805

SLAA:

EUU25_06490

BLAS:

BSY18_3598

TFV:	IDJ81_09110

QSP:	L1F33_00225

QSO:	IRL76_09085

QAR:	K3148_02395

QGE:	K3136_10945

ELI:

ELI_00035

ELQ:	Ga0102493_112805

EMV:	HQR01_02800

PNS:	A9D12_00115

PORL:

BG023_111657

PHZ:	CHX26_12895

POT:	E2E27_09260

AFLV:

QQW98_01585

SHUM:

STHU_50800

SVC:	STVA_50710

STEL:

STAQ_45970

ABS:	AZOBR_p410033

ABQ:	ABAZ39_30385

ABF:	AMK58_26085

ATI:	AL072_22095

AZT:	TSH58p_19350

AZM:	DM194_21400

AARE:

D3093_29555

SKT:	IGS68_10650

SMUC:

JL100_016580

SROE:

JL101_015005

RRU:

Rru_A3064

RRF:

F11_15695

RPM:	RSPPHO_00637

MGY:	MGMSRv2__2675(mmgC)

MGRY:

MSR1_36910(mmgC_5)

MAGX:

XM1_1236(mmgC)

MAGN:

WV31_14295

FER:	FNB15_00570

DEX:	HWD60_01575

DVN:	HQ394_15005

MAG:

amb0308

HTQ:	FRZ44_46300

HADH:

FRZ61_44230

TXI:

TH3_17600

THAC:

CSC3H3_16690

TII:	DY252_04205

THAI:

IT893_16605

TLU:	R1T41_05155

TTB:	MACH01_32660

MAGQ:

MGMAQ_3099

VSU:	P3M64_11855

THAR:

T8K17_03760

TMO:

TMO_0120

ECOG:

FIV45_15330

SNEA:

NBZ79_17895

SCL:

sce0587

SCU:	SCE1572_04065

ERZ:	ER308_13570

EUZ:	DVS28_a4047

NOW:	GBF35_13605

ABAI:

IMCC26256_11419

AFO:

Afer_1770

AYM:	YM304_14140

ATQ:	GH723_12935

AQZ:	KSP35_23260

IAM:	HC251_17070

IMA:	PO878_07060

DHI:	LH044_19190

LIL:	LA_0560(caiA)

LIE:	LIF_A0461(caiA)

LIC:

LIC_13009

LIS:	LIL_13118(caiA9)

LBJ:

LBJ_2405

LBL:

LBL_0703

LBI:	LEPBI_I3317(acdA3)

LBF:

LBF_3202

LST:

LSS_06909

LAJ:	A0128_02880

LMAY:

DPV73_01935

LKM:	EFP84_13705

LWL:	FHG68_15305

LKB:	LPTSP3_g34580(caiA_8)

LNO:	MAL08_02195

LKR:	FH602_03205

TPX:	Turpa_3980

» show all

Reference

1 [PMID:19703103]

Authors

Erb TJ, Fuchs G, Alber BE.

Title

(2S)-Methylsuccinyl-CoA dehydrogenase closes the ethylmalonyl-CoA pathway for acetyl-CoA assimilation.

Journal

Mol Microbiol 73:992-1008 (2009)
DOI:10.1111/j.1365-2958.2009.06837.x

Sequence

[rsp:RSP_1679]

Other DBs

ExplorEnz - The Enzyme Database:

1.3.8.12

IUBMB Enzyme Nomenclature:

1.3.8.12

ExPASy - ENZYME nomenclature database:

1.3.8.12

BRENDA, the Enzyme Database:

1.3.8.12

DBGET integrated database retrieval system