KEGG   ENZYME: 1.3.8.15
Entry
EC 1.3.8.15                 Enzyme                                 
Name
3-(aryl)acrylate reductase;
acdA (gene name)
Class
Oxidoreductases;
Acting on the CH-CH group of donors;
With a flavin as acceptor
Sysname
3-(phenyl)propanoate:electron-transfer flavoprotein 2,3-oxidoreductase
Reaction(IUBMB)
(1) phloretate + electron-transfer flavoprotein = 4-coumarate + reduced electron-transfer flavoprotein [RN:R12534];
(2) 3-phenylpropanoate + electron-transfer flavoprotein = trans-cinnamate + reduced electron-transfer flavoprotein [RN:R12535];
(3) 3-(1H-indol-3-yl)propanoate + electron-transfer flavoprotein = 3-(indol-3-yl)acrylate + reduced electron-transfer flavoprotein [RN:R12536]
Reaction(KEGG)
R12534 R12535 R12536
Substrate
phloretate [CPD:C01744];
electron-transfer flavoprotein [CPD:C04253];
3-phenylpropanoate [CPD:C05629];
3-(1H-indol-3-yl)propanoate [CPD:C22236]
Product
4-coumarate [CPD:C00811];
reduced electron-transfer flavoprotein [CPD:C04570];
trans-cinnamate [CPD:C00423];
3-(indol-3-yl)acrylate [CPD:C21283]
Comment
The enzyme, found in some amino acid-fermenting anaerobic bacteria, participates in the fermentation pathways of L-phenylalanine, L-tyrosine, and L-tryptophan. Unlike EC 1.3.1.31, 2-enoate reductase, this enzyme has minimal activity with crotonate.
History
EC 1.3.8.15 created 2019
Orthology
K24016  3-(aryl)acrylate reductase
Genes
CBO: CBO3288(acdA)
CBA: CLB_3344
CBH: CLC_3230
CBY: CLM_3721
CBL: CLK_2704
CBB: CLD_1235
CBI: CLJ_B3568
CBF: CLI_3458
CBJ: H04402_03373
CLD: CLSPO_c34080(mmgC)
PEB: O0R46_02465
 » show all
Reference
1  [PMID:29168502]
  Authors
Dodd D, Spitzer MH, Van Treuren W, Merrill BD, Hryckowian AJ, Higginbottom SK, Le A, Cowan TM, Nolan GP, Fischbach MA, Sonnenburg JL
  Title
A gut bacterial pathway metabolizes aromatic amino acids into nine circulating metabolites.
  Journal
Nature 551:648-652 (2017)
DOI:10.1038/nature24661
  Sequence
[cld:CLSPO_c34080]
Other DBs
ExplorEnz - The Enzyme Database: 1.3.8.15
IUBMB Enzyme Nomenclature: 1.3.8.15
ExPASy - ENZYME nomenclature database: 1.3.8.15
BRENDA, the Enzyme Database: 1.3.8.15

  All links  
Chemical substance (8)   
   KEGG COMPOUND (8)   
Chemical reaction (4)   
   KEGG REACTION (3)   
   KEGG RCLASS (1)   
Gene (12)   
   KEGG ORTHOLOGY (1)   
   KEGG GENES (11)   
Protein sequence (2)   
   UniProt (1)   
   SWISS-PROT (1)   
DNA sequence (2)   
   GenBank (1)   
   EMBL (1)   
Protein domain (8)   
   InterPro (8)   
All databases (36)   

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