KEGG   ENZYME: 1.3.8.16
Entry
EC 1.3.8.16                 Enzyme                                 
Name
2-amino-4-deoxychorismate dehydrogenase;
ADIC dehydrogenase;
2-amino-2-deoxyisochorismate dehydrogenase;
SgcG
Class
Oxidoreductases;
Acting on the CH-CH group of donors;
With a flavin as acceptor
Sysname
(2S)-2-amino-4-deoxychorismate:FMN oxidoreductase
Reaction(IUBMB)
(2S)-2-amino-4-deoxychorismate + FMN = 3-(1-carboxyvinyloxy)anthranilate + FMNH2 [RN:R09559]
Reaction(KEGG)
R09559
Substrate
(2S)-2-amino-4-deoxychorismate [CPD:C18054];
FMN [CPD:C00061]
Product
3-(1-carboxyvinyloxy)anthranilate [CPD:C19686];
FMNH2 [CPD:C01847]
Comment
The sequential action of EC 2.6.1.86, 2-amino-4-deoxychorismate synthase and this enzyme leads to the formation of the benzoxazolinate moiety of the enediyne antitumour antibiotic C-1027 [1,2].
History
EC 1.3.8.16 created 2008 as 1.3.99.24, transferred 2020 to EC 1.3.8.16.
Pathway
ec01059  Biosynthesis of enediyne antibiotics
ec01100  Metabolic pathways
ec01110  Biosynthesis of secondary metabolites
Orthology
K20156  2-amino-4-deoxychorismate dehydrogenase
Genes
PCHPC4K32_3170
PSEPC4K39_5021
PPAELDL65_12310
SGBWQO_33810
STIRDDW44_31325
SLIAHA039_12525
NEXNE857_12075
DFUDfulv_33860
DROSDrose_13375
Reference
1  [PMID:18182490]
  Authors
Van Lanen SG, Lin S, Shen B
  Title
Biosynthesis of the enediyne antitumor antibiotic C-1027 involves a new branching point in chorismate metabolism.
  Journal
Proc Natl Acad Sci U S A 105:494-9 (2008)
DOI:10.1073/pnas.0708750105
  Sequence
Reference
2
  Authors
Yu, L., Mah, S., Otani, T. and Dedon, P.
  Title
The benzoxazolinate of C-1027 confers intercalative DNA binding.
  Journal
J Am Chem Soc 117:8877-8878 (1995)
Other DBs
ExplorEnz - The Enzyme Database: 1.3.8.16
IUBMB Enzyme Nomenclature: 1.3.8.16
ExPASy - ENZYME nomenclature database: 1.3.8.16
BRENDA, the Enzyme Database: 1.3.8.16

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