Entry
Name
2-amino-4-deoxychorismate dehydrogenase;
ADIC dehydrogenase;
2-amino-2-deoxyisochorismate dehydrogenase;
SgcG
Class
Oxidoreductases;
Acting on the CH-CH group of donors;
With a flavin as acceptor
BRITE hierarchy
Sysname
(2S)-2-amino-4-deoxychorismate:FMN oxidoreductase
Reaction(IUBMB)
(2S)-2-amino-4-deoxychorismate + FMN = 3-(1-carboxyvinyloxy)anthranilate + FMNH2 [RN:
R09559 ]
Reaction(KEGG)
Substrate
(2S)-2-amino-4-deoxychorismate [CPD:
C18054 ];
FMN [CPD:
C00061 ]
Product
3-(1-carboxyvinyloxy)anthranilate [CPD:
C19686 ];
FMNH2 [CPD:
C01847 ]
Comment
The sequential action of EC
2.6.1.86 , 2-amino-4-deoxychorismate synthase and this enzyme leads to the formation of the benzoxazolinate moiety of the enediyne antitumour antibiotic C-1027 [1,2].
History
EC 1.3.8.16 created 2008 as 1.3.99.24, transferred 2020 to EC 1.3.8.16.
Pathway
ec01059 Biosynthesis of enediyne antibiotics
ec01110 Biosynthesis of secondary metabolites
Orthology
K20156 2-amino-4-deoxychorismate dehydrogenase
Genes
Taxonomy
Reference
Authors
Van Lanen SG, Lin S, Shen B
Title
Biosynthesis of the enediyne antitumor antibiotic C-1027 involves a new branching point in chorismate metabolism.
Journal
Sequence
Reference
2
Authors
Yu, L., Mah, S., Otani, T. and Dedon, P.
Title
The benzoxazolinate of C-1027 confers intercalative DNA binding.
Journal
J Am Chem Soc 117:8877-8878 (1995)
Other DBs
ExplorEnz - The Enzyme Database: 1.3.8.16
ExPASy - ENZYME nomenclature database: 1.3.8.16