KEGG ENZYME: 1.3.8.17

ENZYME: 1.3.8.17

Entry

EC 1.3.8.17                 Enzyme

Name

dehydro coenzyme F420 reductase;
fbiB (gene name)

Class

Oxidoreductases;
Acting on the CH-CH group of donors;
With a flavin as acceptor

Sysname

oxidized coenzyme F420-0:FMN oxidoreductase

Reaction(IUBMB)

oxidized coenzyme F420-0 + FMN = dehydro coenzyme F420-0 + FMNH2 [RN:R12720]

Reaction(KEGG)

R12720

Substrate

oxidized coenzyme F420-0 [CPD:C19153];
FMN [CPD:C00061]

Product

dehydro coenzyme F420-0 [CPD:C22277];
FMNH2 [CPD:C01847]

Comment

This enzyme is involved in the biosynthesis of factor 420 (coenzyme F420), a redox-active compound found in all methanogenic archaea, as well as some eubacteria. In some eubacteria the enzyme is multifunctional, also catalysing the activities of EC 6.3.2.31, coenzyme F420-0:L-glutamate ligase, and EC 6.3.2.34, coenzyme F420-1:gamma-L-glutamate ligase.

History

EC 1.3.8.17 created 2021

Pathway

ec00680

Methane metabolism

ec01100

Metabolic pathways

ec01120

Microbial metabolism in diverse environments

Orthology

K24998

dehydro coenzyme F420 reductase / coenzyme F420-0:L-glutamate ligase / coenzyme F420-1:gamma-L-glutamate ligase

Genes

DNP:	N8A98_18065(cofE)

MTU:	Rv3262(fbiB)

MTV:

RVBD_3262

MTC:

MT3361

MRA:	MRA_3303(fbiB)

MTF:	TBFG_13291

MTB:	TBMG_03310

MTK:	TBSG_03333

MTZ:	TBXG_003290

MTI:	MRGA423_20440

MTE:	CCDC5079_3010

MTUR:

CFBS_3451(fbiB)

MTL:	CCDC5180_2973

MTO:	MTCTRI2_3329(fbiB)

MTD:	UDA_3262(fbiB)

MTN:	ERDMAN_3576(fbiB)

MTJ:	J112_17525

MTUB:

MT7199_3304

MTUE:

J114_17485

MTX:	M943_16850

MTUL:

TBHG_03198

MTUT:

HKBT1_3438(fbiB)

MTUU:

HKBT2_3445(fbiB)

MTQ:	HKBS1_3448(fbiB)

MBO:	BQ2027_MB3290(fbiB)

MBB:	BCG_3291(fbiB)

MBT:	JTY_3287(fbiB)

MBM:	BCGMEX_3289(cofE)

MBK:	K60_033910

MBX:

BCGT_3129

MAF:	MAF_32730(fbiB)

MMIC:

RN08_3597

MCE:	MCAN_32811(fbiB)

MCQ:	BN44_70047(fbiB)

MCV:	BN43_60272(fbiB)

MCX:	BN42_41313(fbiB)

MCZ:	BN45_60292(fbiB)

MORY:

MO_003408

MLE:

ML0758

MLB:

MLBr00758

MPA:

MAP_3375

MAO:

MAP4_0407

MAVI:

RC58_01945

MAVU:

RE97_01955

MAV:

MAV_4225

MIT:

OCO_40840

MIA:

OCU_40750

MID:

MIP_06149

MYO:

OEM_41100

MCHI:

AN480_21445

MIR:

OCQ_42110

MMAL:

CKJ54_19480

MLP:

MLM_3384

MMAN:

MMAN_28880(fbiB)

MSA:	Mycsm_01370

MUL:	MUL_2607(fbiB)

MMI:	MMAR_1280(fbiB)

MMAE:

MMARE11_12460(fbiB)

MLI:	MULP_01441(fbiB)

MPSE:

MPSD_14580(fbiB)

MSHO:

MSHO_60300(fbiB)

MMC:

Mmcs_1323

MKM:

Mkms_1340

MJL:

Mjls_1359

MMM:

W7S_20390

MKN:	MKAN_21195

MYV:	G155_09330

MYE:	AB431_07855

MHAD:

B586_17495

MDX:	BTO20_26035

MSHG:

MSG_01180(fbiB)

MFJ:	MFLOJ_22080(fbiB)

MSTO:

MSTO_25790(fbiB)

MSIM:

MSIM_13090(fbiB)

MSAK:

MSAS_48330(fbiB)

MKU:	I2456_06470

MLW:	MJO58_06215

MXE:	MYXE_37100(fbiB)

MNV:	MNVI_28170(fbiB)

MPAG:

C0J29_07130

MNM:	MNVM_30580(fbiB)

MGOR:

H0P51_06355

MCOO:

MCOO_44630(fbiB)

MBAI:

MB901379_01171(fbiB)

MSEO:

MSEO_51120(fbiB)

MHEK:

JMUB5695_03655(fbiB)

MGAU:

MGALJ_57750(fbiB)

MLJ:	MLAC_04490(fbiB)

MBRD:

MBRA_03620(fbiB)

MSHJ:

MSHI_24910(fbiB)

MMAM:

K3U93_05770

MSPG:

F6B93_05480

MOT:	LTS72_18970

MLM:	MLPF_1194(cofE)

MPAA:

MKK62_18625

MMEH:

M5I08_09055

MKY:	IWGMT90018_13200(fbiB)

MADI:

A7U43_23060

MWU:	PT015_23825

MSM:	MSMEG_1829

MSG:	MSMEI_1786(cofE)

MSB:	LJ00_09120

MSN:	LI99_09120

MSH:	LI98_09120

MVA:

Mvan_1732

MGI:

Mflv_4731

MSP:	Mspyr1_40650

MCB:	Mycch_1341

MNE:	D174_08420

MYN:	MyAD_08275

MFT:	XA26_18660

MPHL:

MPHLCCUG_01626(fbiB_3)

MVQ:

MYVA_1476

MRH:	MycrhN_0423

MTHN:

4412656_01186

MHAS:

MHAS_00503(fbiB)

MDU:	MDUV_28080(fbiB)

MCHT:

MCHIJ_50210(fbiB)

MDR:	MDOR_09060(fbiB)

MAUU:

NCTC10437_01439

MMAG:

MMAD_14820(fbiB)

MMOR:

MMOR_51220(fbiB)

MFX:	MFAL_19180(fbiB)

MAIC:

MAIC_13030(fbiB)

MIJ:	MINS_15970(fbiB)

MALV:

MALV_19540(fbiB)

MTY:	MTOK_35130(fbiB)

MPSC:

MPSYJ_49690(fbiB)

MARZ:

MARA_24300(fbiB)

MGAD:

MGAD_25260(fbiB)

MHEV:

MHEL_36230(fbiB)

MSAR:

MSAR_04250(fbiB)

MANY:

MANY_52680(fbiB)

MAUB:

MAUB_17100(fbiB)

MPOF:

MPOR_20170(fbiB)

MPHU:

MPHO_54230(fbiB)

MMUC:

C1S78_020465

MMAT:

MMAGJ_47580(fbiB)

MBOK:

MBOE_56010(fbiB)

MFG:	K6L26_23200

MSEI:

MSEDJ_27360(fbiB)

MFLV:

NCTC10271_03864

MCEE:

MCEL_20350(fbiB)

MBRM:

L2Z93_003007

MMON:

EWR22_07035

MGO:	AFA91_29765

MHOL:

K3U96_19390

MSEN:

K3U95_20445

MPAE:

K0O64_07420

MRF:	MJO55_07465

MDF:	K0O62_07960

MCRO:

MI149_08400

MGRO:

FZ046_13185

MKR:	MKOR_20220(fbiB)

MPAK:

MIU77_13980

MAB:

MAB_3608

MMV:	MYCMA_1979

MABB:

MASS_3615

MABL:

MMASJCM_3605

MCHE:

BB28_18455

MIZ:	BAB75_20520

MSTE:

MSTE_03740(fbiB)

MSAO:

MYCSP_16600

MSAL:

DSM43276_03406(fbiB_2)

MJD:	JDM601_3011(fbiB)

MTER:

4434518_02998(fbiB)

MMIN:

MMIN_07420(fbiB)

MHIB:

MHIB_24550(fbiB)

MHER:

K3U94_17040

MVM:	MJO54_17060

ASD:

AS9A_3811

NFA:

NFA_46200

NFR:	ERS450000_05308

NCY:	NOCYR_4343(cofE)

NBR:	O3I_035155

NNO:	NONO_c63240(cofE)

NSL:	BOX37_24635

NSR:	NS506_02073(cofE)

NTP:	CRH09_32615

NOZ:	DMB37_13815

NOD:	FOH10_03605

NAH:	F5544_37070

NAD:	NCTC11293_05924

NWL:	NWFMUON74_13470(fbiB)

NIE:	KV110_34190

NTC:	KHQ06_12820

NHU:	H0264_12275

NYA:	LTV02_20665

NGP:	LTT66_19775

NSPU:

IFM12276_09360(fbiB)

NYU:	D7D52_00680

RHA:	RHA1_ro06311

RER:	RER_21520(fbiB)

REY:

O5Y_10280

REB:	XU06_10505

RQI:	C1M55_10945

ROP:	ROP_63730(fbiB)

ROA:	Pd630_LPD02975

RPY:	Y013_07660

RBY:	CEJ39_18580

RHB:

NY08_1684

RAV:	AAT18_17235

RFA:	A3L23_00048(fbiB_1)

RHS:	A3Q41_03365(fbiB_1)

RHW:	BFN03_04460

RRZ:	CS378_06790

RHU:	A3Q40_02035(fbiB_2)

RHQ:	IM25_21975

RHOD:

AOT96_21125

RRT:	4535765_03352

RCR:	NCTC10994_03905

RTM:	G4H71_17760

RKO:	JWS14_25820 JWS14_34320

RGO:	KYT97_07800

ROZ:	CBI38_19205

RPSK:

JWS13_09600

RGOR:

NMQ04_14470

RANT:

RHODO2019_03495

RHOP:

D8W71_13905

REQ:

REQ_33520

WHR:	OG579_05890

GBR:

Gbro_3303

GPO:	GPOL_c30990(cofE)

GOR:

KTR9_3343

GOQ:	ACH46_06010

GTA:	BCM27_16975

GOC:	CXX93_08500

GIT:	C6V83_14660

GRU:	GCWB2_17195(fbiB2)

GOM:	D7316_05386(fbiB_2)

GAV:	C5O27_11005

GOD:	GKZ92_16075

GAM:	GII34_16030

GPD:	GII33_15470

GJI:	H1R19_16015

GOI:	LK459_17875

GHN:	MVF96_16440

GAMI:

IHQ52_19980

GMG:	NWF22_01505

GSI:	P5P27_13750

SPIN:

KV203_15570

TPR:

Tpau_1182

TPUL:

TPB0596_34400(fbiB)

TSD:	MTP03_12310(fbiB)

SRT:

Srot_2671

DTM:	BJL86_1019

DIT:	C3V38_10625

DIZ:	CT688_04535

DPC:	A6048_04610

DLU:	A6035_04845

DKN:	NHB83_04365

TOY:	FO059_04830

SCO:	SCO3037(SCE34.18)

SALB:

XNR_1924

SMA:	SAVERM_5039(cofE)

SGR:

SGR_4500

SGB:

WQO_13020

SFI:

SFUL_2633

SANL:

KZO11_13380

SGRF:

SGFS_049900

SCYE:

R2B67_22610

SCB:	SCAB_55051(cofE)

SSX:	SACTE_2503

SVL:	Strvi_8423

SHY:

SHJG_4504

SHO:	SHJGH_4267

SRC:	M271_29475

SMAL:

SMALA_3142

SSOI:

I1A49_19505

SFA:

Sfla_3870

SBH:

SBI_04466

SVE:

SVEN_2779

SDV:	BN159_5255(cofE)

SALS:

SLNWT_2577

STRP:

F750_2862

SCI:	B446_15770

SLV:	SLIV_22510(fbiB)

SGU:	SGLAU_13805(fbiB)

SVT:	SVTN_14815

STRE:

GZL_05424

SCW:	TU94_13265

SLD:

T261_5067

SLC:	SL103_04165

SXI:	SXIM_18240

STRM:

M444_14305

STRC:

AA958_11405

SAMB:

SAM23877_3079(fbiB)

SPRI:

SPRI_4520

SCZ:	ABE83_22875

SCX:	AS200_27265

SRW:	TUE45_04628(fbiB)

STRF:

ASR50_20135

SLE:	sle_42440(sle_42440)

SRN:	A4G23_02040(fbiB)

SPAV:

Spa2297_13150

STRT:

A8713_12285

SCLF:

BB341_17710

SGS:	AVL59_42925

STSI:

A4E84_15955

SKY:	D0C37_11385

SALW:

CP975_13855

SGM:	GCM10017557_50170(fbiB)

SCAD:

DN051_23465

SPHW:

NFX46_36015

SLS:	SLINC_3443

SNR:	SNOUR_25325

SALU:

DC74_3466

SALL:

SAZ_18455

SPLU:

LK06_011885

STRD:

NI25_23605

SNW:	BBN63_21600

SAUO:

BV401_19200

SSIA:

A7J05_21720

SVU:	B1H20_12300

SPUN:

BFF78_25295

SGV:	B1H19_16745

SLAU:

SLA_2760

SALF:

SMD44_03377(cofE)

SALJ:

SMD11_4188(cofE)

SLX:	SLAV_22855(fbiB2)

STRO:

STRMOE7_15725

SFK:

KY5_3202

SNZ:	DC008_13675

SGE:	DWG14_05053(fbiB)

SRJ:

SRO_4452

SLK:	SLUN_15505

SDX:	C4B68_24085

SGD:	ELQ87_23315

SQZ:	FQU76_11445

SCYA:

EJ357_18280

SAST:

CD934_20160

SNQ:	CP978_14105

STIR:

DDW44_10220

SKA:	CP970_26365

SGZ:	C0216_27105

SVN:	CP980_20515

SNK:	CP967_21060

SHAW:

CEB94_16545

SRK:	FGW37_12640

SFIC:

EIZ62_20205

SGAL:

CP966_14465

SSPO:

DDQ41_08710

SVR:	CP971_20715

SPAD:

DVK44_11200

SFY:	GFH48_24385

SAQU:

EJC51_20735

SGF:	HEP81_04779

SCAV:

CVT27_11715

SSEO:

D0Z67_11260

SBY:	H7H31_22365

SRIM:

CP984_24925

SSUB:

CP968_20295

SPHV:

F9278_18580

SCIN:

CP977_13490

SFUG:

CNQ36_13865

SPAC:

B1H29_22320

STSU:

B7R87_11095

SCHA:

CP983_26045

SGX:	H4W23_16035

SCOE:

CP976_17680

SBAT:

G4Z16_21465

SSPB:

CP982_17990

SNF:	JYK04_03614(fbiB_1)

SPLA:

CP981_15395

SBRO:

GQF42_18835

STUI:

GCM10017668_27350(fbiB)

SATA:

C5746_16555

SCHF:

IPT68_14690

SHUN:

DWB77_04646(fbiB_2)

SHAR:

HUT13_11500

SCYG:

S1361_16340(fbiB)

SFEU:

IM697_05850

SLIA:

HA039_21540

SDW:	K7C20_14510

SVD:	CP969_16340

SCAL:

I6J39_12570

SAUH:

SU9_012975

SFB:	CP974_11285

SMOB:

J7W19_12340

SPRA:

CP972_14540

SPEU:

CGZ69_13690

SROI:

IAG44_24880

SXN:	IAG42_21210

SGJ:	IAG43_12135

SHK:	J2N69_14070

SANU:

K7396_22165

SDD:	D9753_21320

SACT:

DMT42_15905

SMAO:

CAG99_17345

SGOB:

test1122_08560

SINE:

KI385_18465

SLF:	JEQ17_28335

SDEC:

L3078_18490

SAOV:

G3H79_22485

SDUR:

M4V62_25480

SYAN:

NRK68_13435

SRUG:

F0345_18620

SAKB:

K1J60_26675

STAA:

LDH80_24405

SNIG:

HEK616_03460(fbiB)

SVIO:

HWN34_10310

SCAE:

IHE65_27105

STUB:

MMF93_13300

SSPN:

LXH13_24560

SCIR:

STRCI_003389

SXT:	KPP03845_103148(fbiB_1)

SLON:

LGI35_19610

SDRZ:

NEH16_19510

STUD:

STRTU_004362

STEE:

F3L20_28450

SGK:	PET44_13120

SANT:

QR300_25825

SYUN:

MOV08_25555

SARG:

HKX69_20690

SJN:	RI060_25605

SOV:	QZH56_22290

SFIY:

F0344_22265

SHAU:

K9S39_27470

SKG:	KJK29_22835

SCOA:

QU709_25810

SLAI:

P8A22_24065

SROC:

RGF97_20420

SFP:	QUY26_24020

SCHG:

NRO40_11415

STTN:

BSL84_13015

SINN:

ABB07_22760

STRZ:

OYE22_21530

SCT:	SCAT_2044(cofE)

SCY:	SCATT_20260

KSK:	KSE_29440(fbiB)

KAB:	B7C62_12015

KAU:	B6264_15380

KIT:	CFP65_2740

KIS:	HUT16_12695

STRI:

C7M71_010640

YIA:	LO772_21665

STRH:

GXP74_06010

ABRY:

NYE86_05085

AGLA:

OIE69_24370

PSIC:

J4E96_05755

MSUW:

GCM10025863_29280

MINV:

T9R20_02875(cofE)

MOJ:	D7D94_12245(cofE)

AARC:

G127AT_06815(cofE)

AMAU:

DSM26151_28160(fbiB_1) DSM26151_28190(fbiB_2)

ASOI:

MTP13_06230(cofE)

AMAV:

GCM10025877_13560

ALAV:

MTO99_13440

AIL:	FLP10_09960

MHUM:

NNL39_01335(cofE) NNL39_01525(cofE)

MDB:	OVN18_01245(cofE)

LARI:

KI794_01770(cofE)

LALL:

MUN78_02050(cofE)

AGRO:

JSQ78_05250(cofE)

HEH:	L3i23_06140

SUBT:

KPL76_08050

HOM:	OF852_06420

NAEI:

GCM126_22220

AOG:	LH407_11845

AJG:	KKR91_03250(cofE)

ASUN:

KG104_02965(cofE)

ACAO:

NF551_09370

AGEG:

MUG94_02860(cofE)

AKO:	N9A08_09055

AJR:	N2K98_15950(cofE)

BKI:	M4486_01575

BRHA:

NLU66_09265

BHH:	Bra3105_17435(cofE)

BHQ:	BRM3_08575(cofE)

YIM:	J5M86_04315

ALX:	LVQ62_16230(cofE)

CELC:

K5O09_06655

CCHE:

NP064_10590

PSEK:

GCM125_00170 GCM125_32860

TED:	U5C87_20330

OCP:	NF557_11785

GYU:	FE374_05890(cofE)

RHAL:

LQF10_12455(cofE)

RSUA:

LQF12_05810(cofE)

NARO:

CFH99_18255

NPI:	G7071_09225(cofE)

NAQU:

ENKNEFLB_03315(fbiB)

NRO:	K8W59_12200(cofE)

NCQ:	K6T13_04830(cofE)

NPC:	KUV85_01615(cofE)

NMAR:

HPC71_16185(cofE)

NFC:	KG111_04140(cofE)

ASEZ:

H9L21_12205(cofE)

ADB:	NP095_12155(cofE)

AWN:	NQV15_02665(cofE)

SGRG:

L0C25_15965(cofE)

NBT:	KLP28_10505(cofE)

KSL:	OG809_19280

TFU:

Tfu_2518

THAO:

NI17_015400

TALX:

FOF52_12870

NDA:

Ndas_3768

NAL:	B005_0946(cofE)

NGV:	CDO52_24250

NEX:	NE857_28265

NAKE:

KGD83_06370

NCG:	KGD84_05645

STRR:

EKD16_04580(fbiB)

SNAH:

OUQ99_05235

SAIU:

J4H86_12280

TCU:

Tcur_4073

ACTW:

F7P10_11800

AGRA:

AGRA3207_002959

AMAZ:

LUW76_18150

ACIR:

OG979_24045

SPIQ:

OHA34_18500

ACTQ:

OG417_07115

SRO:

Sros_1379

NOA:	BKM31_38775

NOW:	GBF35_06595

NCX:	Nocox_05950(fbiB1)

NGN:	LCN96_06640

NFS:	OIE67_40365

TBI:

Tbis_0748

MHAI:

OHB01_17500

FRA:	Francci3_0741

FRE:	Franean1_5869

FAL:

FRAAL1259

FSY:	FsymDg_1076

FRI:	FraEuI1c_6072

ACE:

Acel_1962

NML:

Namu_4176

NAK:	EH165_10590

NAKA:

H7F38_11380

BLAP:

MVA48_20175

SEN:

SACE_6467

SACG:

FDZ84_07210

SVI:	Svir_06230

SACC:

EYD13_03495(fbiB1)

AMD:

AMED_1022

AMN:

RAM_05200

AMM:

AMES_1018

AMZ:

B737_1019

AOI:	AORI_1009(cofE)

AJA:	AJAP_34535(fbiB)

AMQ:	AMETH_0931

AMYC:

CU254_03580

AMYB:

BKN51_39150

AAB:	A4R43_35495

AMYY:

YIM_42560(fbiB2)

AORI:

SD37_36145

AACD:

LWP59_04470

APRT:

MUY14_31685

AROO:

NQK81_17835

ATHM:

L1857_07275

ARHD:

VSH64_42690

PDX:

Psed_5207

PSEA:

WY02_11515

PSEE:

FRP1_02695

PSEH:

XF36_02100

PSEQ:

AD006_10310

PECQ:

AD017_18140

PHH:	AFB00_16170

PAUT:

Pdca_56440

PBRO:

HOP40_13555

PPEL:

H6H00_13220

APRE:

CNX65_31170

AMI:

Amir_6334

SESP:

BN6_76250(cofE)

SSYI:

EKG83_42420

KAL:

KALB_7914

KUT:	JJ691_87190

KBU:	Q4V64_20170

KPHY:

AOZ06_48155

LED:	BBK82_19180

AHM:	TL08_23385

ACTI:

UA75_27205

ACAD:

UA74_26615

AHG:	AHOG_24535(fbiB)

ACTA:

C1701_14675

ALO:

CRK59729

PMAD:

BAY61_03990

SACE:

GIY23_18810

ACTU:

Actkin_05520(fbiB_3)

CROS:

N8J89_04765

ACTY:

OG774_12795

UME:	RM788_20705

AIH:	Aiant_52200

ACTL:

L3i22_009060

ASIC:

Q0Z83_079590

AOU:	ACTOB_000874

ASER:

Asera_25000(fbiB)

DVC:	Dvina_48730

DFU:	Dfulv_43315

DROS:

Drose_33165

DMAT:

Dmats_43270

NHY:	JQS43_20535

CAI:

Caci_7612

AEY:	CDG81_04205

JTL:	M6D93_14720

JCY:	M6B22_07540

AQZ:	KSP35_00875(cofE)

IAM:	HC251_16065(cofE)

IMA:	PO878_14430(cofE)

MICA:

P0L94_12005(cofE)

LOKI:

Lokiarch_23940(cofE_1) Lokiarch_46970(cofE_3)

» show all

Reference

1 [PMID:30952857]

Authors

Bashiri G, Antoney J, Jirgis ENM, Shah MV, Ney B, Copp J, Stuteley SM, Sreebhavan S, Palmer B, Middleditch M, Tokuriki N, Greening C, Scott C, Baker EN, Jackson CJ

Title

A revised biosynthetic pathway for the cofactor F420 in prokaryotes.

Journal

Nat Commun 10:1558 (2019)
DOI:10.1038/s41467-019-09534-x

Sequence

[mtu:Rv3262]

Other DBs

ExplorEnz - The Enzyme Database:

1.3.8.17

IUBMB Enzyme Nomenclature:

1.3.8.17

ExPASy - ENZYME nomenclature database:

1.3.8.17

BRENDA, the Enzyme Database:

1.3.8.17

All links

Pathway (6)   
   KEGG PATHWAY (6)   
Chemical substance (4)   
   KEGG COMPOUND (4)   
Chemical reaction (1)   
   KEGG REACTION (1)   
Gene (922)   
   KEGG ORTHOLOGY (1)   
   KEGG GENES (603)   
   KEGG MGENES (318)   
Protein sequence (1260)   
   UniProt (1246)   
   SWISS-PROT (14)   
Protein domain (6)   
   InterPro (6)   
All databases (2199)   

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