Entry Name 5a,11a-dehydrotetracycline reductase;
Class Oxidoreductases;BRITE hierarchy
Sysname tetracycline:coenzyme F420 dehydrogenase
Reaction(IUBMB) tetracycline + oxidized coenzyme F420 = 5a,11a-dehydrotetracycline + reduced coenzyme F420 [RN:
R05459 ]
Reaction(KEGG) Substrate tetracycline [CPD:
C06570 ];
oxidized coenzyme F420 [CPD:
C00876 ]
Product 5a,11a-dehydrotetracycline [CPD:
C03206 ];
reduced coenzyme F420 [CPD:
C01080 ]
Comment The enzyme, characterized from the bacteria Streptomyces aureofaciens and Streptomyces rimosus, catalyses the last step in the biosynthesis of the tetracycline antibiotics tetracycline and oxytetracycline.
History EC 1.3.98.4 created 2016
Pathway ec01057 Biosynthesis of type II polyketide products
ec01110 Biosynthesis of secondary metabolites
Orthology K21301 5a,11a-dehydrotetracycline reductase
Genes Taxonomy Reference 1
Authors McCormick, J.R.D., Hirsch, U., Sjolander, N.O. and Doerschuk, A.P.
Title Cosynthesis of tetracyclines by pairs of Streptomyces aureofaciens mutants.
Journal J Am Chem Soc 82:5006-5007 (1960)
Reference 2
Authors Miller, P.A., Sjolander, N.O., Nalesnyk, S., Arnold, N., Johnson, S., Doerschuk, A.P. and McCormick, J.R.D.
Title Cosynthetic factor I, a factor involved in hydrogen-transfer in Streptomyces aureofaciens.
Journal J Am Chem Soc 82:5002-5003 (1960)
Reference 3
Authors McCormick, J.R.D. and Morton, G.O.
Title Identity of cosynthetic factor I of Streptomyces aureofaciens and fragment FO from coenzyme F420 of Methanobacterium species.
Journal J Am Chem Soc 104:4014-4015 (1982)
Reference Authors Wang P, Bashiri G, Gao X, Sawaya MR, Tang Y
Title Uncovering the enzymes that catalyze the final steps in oxytetracycline biosynthesis.
Journal Other DBs ExplorEnz - The Enzyme Database: 1.3.98.4
ExPASy - ENZYME nomenclature database: 1.3.98.4
