KEGG ENZYME: 1.3.99.23

ENZYME: 1.3.99.23

Entry

EC 1.3.99.23                Enzyme

Name

all-trans-retinol 13,14-reductase;
retinol saturase;
RetSat;
(13,14)-all-trans-retinol saturase;
all-trans-retinol:all-trans-13,14-dihydroretinol saturase

Class

Oxidoreductases;
Acting on the CH-CH group of donors;
With unknown physiological acceptors

Sysname

all-trans-13,14-dihydroretinol:acceptor 13,14-oxidoreductase

Reaction(IUBMB)

all-trans-13,14-dihydroretinol + acceptor = all-trans-retinol + reduced acceptor [RN:R07163]

Reaction(KEGG)

R07163

Substrate

all-trans-13,14-dihydroretinol [CPD:C15492];
acceptor [CPD:C00028]

Product

all-trans-retinol [CPD:C00473];
reduced acceptor [CPD:C00030]

Comment

The reaction is only known to occur in the opposite direction to that given above, with the enzyme being specific for all-trans-retinol as substrate. Neither all-trans-retinoic acid nor 9-cis, 11-cis or 13-cis-retinol isomers are substrates. May play a role in the metabolism of vitamin A.

History

EC 1.3.99.23 created 2005

Pathway

ec00830

Retinol metabolism

Orthology

K09516

all-trans-retinol 13,14-reductase

Genes

HSA:	54884(RETSAT)

PTR:	470420(RETSAT)

PPS:	100980971(RETSAT)

GGO:	101149338(RETSAT) 101153428

PON:	100433966(RETSAT)

NLE:	100603439(RETSAT)

HMH:	116483595(RETSAT)

MCC:	694896 695058(RETSAT)

MCF:	102124463(RETSAT) 102143939

MTHB:

126933390 126934391

MNI:	105465376(RETSAT) 105465455

CSAB:

103219951 103219955(RETSAT)

CATY:

105587680 105587682(RETSAT)

PANU:

101018628(RETSAT)

TGE:	112604519 112637015

MLEU:

105528846(RETSAT)

RRO:	104654618 104659735

RBB:	108519778(RETSAT)

TFN:	117062126(RETSAT) 117062822

PTEH:

111551144(RETSAT) 111551145

CANG:

105527572(RETSAT)

CJC:	100415049(RETSAT)

SBQ:	101034084(RETSAT)

CIMI:

108295688

CSYR:

103256767(RETSAT)

MMUR:

105876583(RETSAT)

LCAT:

123637118(RETSAT)

PCOQ:

105810283(RETSAT)

OGA:	100955281(RETSAT)

MMU:	67442(Retsat)

MCAL:

110296807(Retsat)

MPAH:

110316602(Retsat)

RNO:	246298(Retsat)

MCOC:

116099087(Retsat)

ANU:	117715376(Retsat)

MUN:	110541203(Retsat)

CGE:	100750576(Retsat)

MAUA:

101826028(Retsat)

PROB:

127235484(Retsat)

PLEU:

114681587(Retsat)

MORG:

121465307(Retsat) 121465318 121465329

MFOT:

126493274 126493275

AAMP:

119806977 119806978

NGI:	103739785(Retsat)

HGL:	101708622(Retsat)

CPOC:

100731102(Retsat)

CCAN:

109686179(Retsat)

DORD:

106000215(Retsat)

DSP:	122116906(Retsat)

PLOP:

125356228(Retsat)

NCAR:

124963180

MMMA:

107159707(Retsat)

OCU:

100348884

OPI:	101522890(RETSAT)

TUP:	102474082(RETSAT)

GVR:	103581386(RETSAT)

CFA:	483083(RETSAT)

CLUD:

112664308(RETSAT)

VVP:	112916683(RETSAT)

VLG:	121490509(RETSAT)

NPO:	129510784(RETSAT)

AML:	100476977(RETSAT)

UMR:	103671449(RETSAT)

UAH:	113243209(RETSAT)

UAR:	123799647(RETSAT)

ELK:

111148026

LLV:

125108461

MPUF:

101672190(RETSAT)

MNP:	132021400(RETSAT)

MLK:	131840379(RETSAT)

NVS:	122915044(RETSAT)

ORO:	101382507(RETSAT)

EJU:	114223451(RETSAT)

ZCA:	113938408(RETSAT)

MLX:	118007919(RETSAT)

NSU:	110587349(RETSAT)

LWW:	102747971(RETSAT)

FCA:	101090345(RETSAT)

PYU:	121019171(RETSAT)

PCOO:

112869162(RETSAT)

PBG:	122497098(RETSAT)

PVIV:

125162249(RETSAT)

LRUF:

124502938

PTG:	102958364(RETSAT)

PPAD:

109263729(RETSAT)

PUC:

125937397

AJU:

106978216

HHV:	120220476(RETSAT)

BTA:	614455(RETSAT)

BOM:	102279340(RETSAT)

BIU:	109566179(RETSAT)

BBUB:

102404646(RETSAT)

BBIS:

105004553(RETSAT)

CHX:	102171615(RETSAT)

OAS:	101123106(RETSAT)

BTAX:

128055340(RETSAT)

ODA:	120851491(RETSAT)

CCAD:

122441731(RETSAT)

MBEZ:

129539304(RETSAT)

SSC:	100519138(RETSAT)

CFR:	102506909(RETSAT)

CBAI:

105072255(RETSAT)

CDK:	105104148(RETSAT)

VPC:	102541965(RETSAT)

BACU:

103009686(RETSAT)

BMUS:

118905863(RETSAT)

LVE:	103068788(RETSAT)

OOR:	101286968(RETSAT)

DLE:	111165413(RETSAT)

PCAD:

102973133(RETSAT) 114485223

PSIU:

116764117(RETSAT)

NASI:

112398968(RETSAT)

ECB:	100067379(RETSAT)

EPZ:	103548266(RETSAT)

EAI:	106838606(RETSAT)

MYB:	102241000(RETSAT)

MYD:	102764075(RETSAT)

MMYO:

118668797(RETSAT)

MLF:	102441868(RETSAT)

PKL:	118717605(RETSAT)

EFUS:

103299039(RETSAT)

MNA:	107528657(RETSAT)

DRO:	112302967(RETSAT)

SHON:

118982383(RETSAT)

AJM:	119059854(RETSAT)

PDIC:

114499690(RETSAT)

PHAS:

123811440(RETSAT)

MMF:	118630655(RETSAT)

PPAM:

129073950(RETSAT)

HAI:	109371326(RETSAT)

RFQ:	117032873(RETSAT)

PALE:

102897460(RETSAT)

PGIG:

120594461(RETSAT)

PVP:	105298540(RETSAT)

RAY:	107506206(RETSAT)

MJV:	108405885(RETSAT)

TOD:	119259126(RETSAT)

SARA:

101546984(RETSAT)

LAV:	100676269(RETSAT)

TMU:	101345756 101346268

ETF:	101663871(RETSAT)

DNM:	101416452(RETSAT)

MDO:	100030257(RETSAT) 100030337

GAS:	123233140 123236674(RETSAT)

SHR:	100921830(RETSAT) 100922093

AFZ:	127547433 127547435

PCW:	110196321 110196356(RETSAT)

OAA:	100087168(RETSAT) 100088936

GGA:	101751434(RETSATL) 426549(RETSAT)

PCOC:

116231337(RETSAT) 116233760

MGP:	100544741(RETSAT) 104915781 104916981

CJO:	107323640(RETSAT) 107325116

TPAI:

128090163(RETSAT)

LMUT:

125685261(RETSAT) 125687673

NMEL:

110387101(RETSAT) 110388620

APLA:

101800761(RETSAT) 119714042

ACYG:

106048918(RETSAT) 106049844

CATA:

118259169 118260944(RETSAT)

AFUL:

116499312(RETSAT)

TGU:	101233661(RETSAT) 115490742

LSR:	110478283(RETSAT)

SCAN:

103822711(RETSAT) 103825395

PMOA:

120498180 120504939(RETSAT)

OTC:	121346666(RETSAT) 121347538

PRUF:

121352440 121359782(RETSAT)

GFR:	102039565(RETSAT)

FAB:	101818337(RETSAT)

OMA:	130261861(RETSAT) 130263948

PHI:	102104553 102109927(RETSAT)

PMAJ:

107199008 107213871(RETSAT)

CCAE:

111938901(RETSAT)

CCW:	104683179(RETSAT) 120411185

CBRC:

103620222(RETSAT)

ETL:	114069043 114070469 114072634

ZAB:	106630056(RETSAT)

ACHL:

103805549(RETSAT)

SVG:	106861175 106862430(RETSAT)

MMEA:

130586306(RETSAT) 130587888

HRT:	120764101(RETSAT)

FPG:	101915211 101922352(RETSAT)

FCH:	102050507(RETSAT) 102055717

CLV:	102089222(RETSAT) 102091836

EGZ:	104121761(RETSAT)

NNI:	104012307 104022618(RETSAT)

PCRI:

104029011(RETSAT)

PCAO:

104052897(RETSAT)

ACUN:

113490222(RETSAT)

TALA:

104362343(RETSAT)

PADL:

103926238(RETSAT)

AFOR:

103904254(RETSAT)

ACHC:

115344351 115349899(RETSAT)

HALD:

104320798(RETSAT)

HLE:	104828900(RETSAT) 104842978

AGEN:

126038444 126051624

GCL:

127025346

CCRI:

104162890(RETSAT)

CSTI:

104557945 104559225

CMAC:

104484660(RETSAT)

MUI:

104538697

BREG:

104639625(RETSAT)

GSTE:

104255509(RETSAT)

NNT:	104405644(RETSAT)

SHAB:

115617799 115618439(RETSAT)

DPUB:

104305639(RETSAT) 104309381

PGUU:

104465108(RETSAT)

CPEA:

104392894(RETSAT)

CVF:	104285060(RETSAT)

RTD:	128919269 128919674(RETSAT)

CUCA:

104066997(RETSAT) 104068291

TEO:	104378302(RETSAT)

AAM:	106493808(RETSAT)

AROW:

112971160(RETSAT)

NPD:	112949035 112955431

DNE:	112987178 112994858(RETSAT)

SCAM:

104148913(RETSAT)

ASN:	102369670(RETSAT)

AMJ:	102576004(RETSAT)

CPOO:

109324642(RETSAT)

GGN:	109286680(RETSAT)

PSS:	102451524(RETSAT)

CMY:	102937353 102947614(RETSAT)

CCAY:

125626491(RETSAT) 125626763

DCC:	119848842(RETSAT) 119849127

CPIC:

101937097 101948187(RETSAT)

TST:	117869357 117872877(RETSAT)

CABI:

116820738(RETSAT) 116831373

MRV:	120391995 120399322(RETSAT)

ACS:	100552731(retsat) 100552879 100554362 100554559

ASAO:

132778138 132778139 132782287(RETSAT)

PVT:	110079148 110079149 110079156 110089218(RETSAT)

SUND:

121932397 121932655(RETSAT) 121935170

VKO:	123027054(RETSAT) 123030666

PMUA:

114585479 114585480

PRAF:

128402554 128402555

ZVI:	118097111 118097112(RETSAT)

HCG:	128328960 128333779(RETSAT)

GJA:	107114725(RETSAT)

STOW:

125441434(RETSAT)

EMC:	129342573(RETSAT)

XLA:	108702543 494824(retsat.L)

XTR:	100158500(retsat) 100488563

NPR:	108783994 108792471

RTEM:

120918712 120933075(RETSAT)

BBUF:

120986165(RETSAT) 121003963

BGAR:

122929476(RETSAT) 122942047

MUO:	115468086 115469282 115469283

GSH:	117362574(RETSAT)

DRE:	325922(retsat.2) 563241(si:ch1073-13h15.3) 677660(retsatl) 777751(retsat.1)

SRX:	107708985 107720034 107737865 107739437 107755357 107755369 107755370

SANH:

107674695 107676090 107676091 107693675 107699030

SGH:	107562027 107591477(retsat) 107601381 107601603

CCAR:

109052113(retsat) 109066427 109066428

CAUA:

113050184(retsat) 113052883 113056432 113108305 113108306

CGIB:

127951632 127964335 127964337 128020108 128025087(si:ch1073-13h15.3)

PTET:

122333433(si:ch1073-13h15.3) 122341859(retsat.2) 122341944 122352090(retsatl)

LROH:

127163562 127170702 127170703 127173682(si:ch1073-13h15.3)

OMC:	131536306 131546454(retsatl) 131550568(si:ch1073-13h15.3)

PPRM:

120469002(si:ch1073-13h15.3) 120486994 120486995 120486996 120489497(retsat)

RKG:	130072026 130072027 130080625(si:ch1073-13h15.3) 130094975

MAMB:

125255946(si:ch1073-13h15.3) 125268406 125270676 125270677 125272310

CIDE:

127509427 127519061 127519063 127524090(si:ch1073-13h15.3)

MASI:

127427386 127450941 127451696

TROS:

130555459(retsatl) 130562263 130568446 130569499(si:ch1073-13h15.3)

TDW:	130407045 130426208(retsat.2) 130427935 130439250(si:ch1073-13h15.3)

MANU:

129414820(retsatl) 129421353(si:ch1073-13h15.3) 129433132(retsat.2)

IPU:	108257121(retsat.2) 108274341 108274342

IFU:	128602362(retsat.2) 128617432 128617459

PHYP:

113527051 113527073 113528295(retsat)

SMEO:

124388397(si:ch1073-13h15.3) 124397158 124397328

TFD:	113652191 113653612 113653613

TVC:	132841527 132841528 132861023

AMEX:

103027967 103033552 103037098 103042924 103044667 107196803 111192380 111192420

CMAO:

118798263 118798270 118798272 118798340 118809801(si:ch1073-13h15.3) 118809802 118820983 118820984 118820985 118821820

EEE:	113574299 113588888(retsat)

CHAR:

105898795(retsat.2) 105907866 105909511(si:ch1073-13h15.3)

TRU:	101062884 101065125 101078075

TFS:	130515137 130515196(retsat.2) 130539649(si:ch1073-13h15.3)

TNG:	GSTEN00021055G001 GSTEN00026983G001 GSTEN00027856G001

LCO:	104926440(retsat) 104928682 104933951

NCC:	104945044 104946857(retsat)

TBEN:

117469270 117473768(si:ch1073-13h15.3) 117493117(retsat)

CGOB:

115011618 115012468 115024812

PGEO:

117451481 117451536(retsat) 117465096(si:ch1073-13h15.3)

GACU:

117547427(si:ch1073-13h15.3) 117548521(retsat) 117558028

EMAC:

134870415(si:ch1073-13h15.3) 134878267(retsat.2) 134878340

ELY:	117246709(si:ch1073-13h15.3) 117267951 117269072(retsat)

EFO:	125879399 125879828(retsat.2) 125880747(si:ch1073-13h15.3)

PLEP:

121956225(retsat.2) 121956356 121959380(si:ch1073-13h15.3)

SLUC:

116061487(si:ch1073-13h15.3) 116063447 116063731(retsat)

ECRA:

117937071(si:ch1073-13h15.3) 117958443(retsat) 117958656

ESP:	116671219 116702779(retsat) 116703638

PFLV:

114548553 114569596 114569782

GAT:	120814308 120819855(si:ch1073-13h15.3) 120827304(retsat.2)

PPUG:

119213149(si:ch1073-13h15.3) 119219845 119220739(retsat)

AFB:	129091402(si:ch1073-13h15.3) 129098433(retsat.2) 129098550

CLUM:

117734767 117734768 117735424(retsat) 117748902(si:ch1073-13h15.3)

PSWI:

130188221(retsat.2) 130203610(si:ch1073-13h15.3)

MSAM:

119882165 119893211(retsat) 119916417(si:ch1073-13h15.3)

SCHU:

122867823(si:ch1073-13h15.3) 122869247 122869350(retsat.2)

CUD:	121503510(retsat.2) 121503847 121528913(si:ch1073-13h15.3)

ALAT:

119010174(si:ch1073-13h15.3) 119014181 119014365(retsat)

MZE:	101465824 101476159 101478120(retsat)

ONL:	100691992 100707878(retsat) 100709359

OAU:	116314381(retsat) 116320097 116336290(si:ch1073-13h15.3)

OLA:	101155933(retsat) 101162403 101173846

OML:	112138826 112146822(retsat) 112153919(si:ch1073-13h15.3)

CSAI:

133419004(si:ch1073-13h15.3) 133421445 133421600 133422225

XMA:	102218343 102226433 102230433 102238190

XCO:	114148867 114151763 114159829 114159830

XHE:	116726806 116735076 116735077 116735507

PRET:

103468165 103469338 103469375 103481656

PFOR:

103131190(retsat) 103151445 103154349

PLAI:

106935641 106946743 106953294 106953308

PMEI:

106908021 106919505 106928506(retsat)

GAF:	122821729 122821730 122821929 122823112(si:ch1073-13h15.3)

PPRL:

129363638 129368282(si:ch1073-13h15.3) 129373943 129373944

CVG:	107084832 107084833 107102378 107104792

CTUL:

119790325 119790326 119791064(si:ch1073-13h15.3) 119798801

GMU:	124862285 124862340 124863243 124864175 124874866(si:ch1073-13h15.3)

NFU:	107378557(retsat) 107387676 107396584

KMR:	108237697(retsat) 108246350(si:ch1073-13h15.3)

ALIM:

106527571(retsat) 106535412

NWH:	119421368(retsat.2) 119423791(si:ch1073-13h15.3)

AOCE:

111568435 111574248 111579233

MCEP:

124997816 124997817 124998112 125022530

CSEM:

103381816 103392752 103393594

POV:	109633999 109640446 109640643

SSEN:

122785321(retsat.2) 122785884

HHIP:

117753062(si:ch1073-13h15.3) 117766878 117767040(retsat)

HSP:	118100709(si:ch1073-13h15.3) 118122937(retsat.2) 118123515

SMAU:

118287303(si:ch1073-13h15.3) 118288688(retsat.2) 118289237

LCF:	108872757 108876653(si:ch1073-13h15.3) 108898512

SDU:	111217763(retsat) 111220358 111223679

SLAL:

111656127 111658468(retsat) 111662398

XGL:	120783462 120783931(retsat.2) 120794665(si:ch1073-13h15.3)

HCQ:	109506812(retsat) 109513268 109532534

SSCV:

125983132 125983989 125991458(si:ch1073-13h15.3)

SBIA:

133495662(si:ch1073-13h15.3) 133514342 133514540

PEE:	133414315(retsat.2) 133414920 133418048(si:ch1073-13h15.3)

PTAO:

133465610(retsat.2) 133469627(si:ch1073-13h15.3) 133477306

BPEC:

110154418 110159281 110162270

MALB:

109963184 109973700 109974888

BSPL:

114845854(si:ch1073-13h15.3) 114860961(retsat.2)

SJO:	128378673 128379037(retsat.2) 128380890(si:ch1073-13h15.3)

SASA:

100196171(retst) 106589635 106600793 106607466

STRU:

115171059 115196638 115197389 115201447

OTW:	112224805(si:ch1073-13h15.3) 112225712 112258607 112258608

OMY:	110485151 110486209 110498780(si:ch1073-13h15.3) 110538135

OGO:	123998590 124016255 124016441 124039032(si:ch1073-13h15.3)

ONE:	115104037 115104082 115110230

OKI:	109893283 109897267 109898377

OKE:	118357705(si:ch1073-13h15.3) 118365231 118370403 118384475

SALP:

111967984 111980733 111981057 111981564

SNH:	120029512(si:ch1073-13h15.3) 120033946 120034124 120035256

CCLU:

121547586(si:ch1073-13h15.3) 121569497 121569628 121569693

ELS:	105007254 105013106 105021176

SFM:	108928164 108941533

PKI:	111848650(retsat)

AANG:

118216029 118217066 118217068 118220047(si:ch1073-13h15.3)

LOC:	102682797 102691359 102692774

PSPA:

121301708(si:ch1073-13h15.3) 121302001

ARUT:

117433256 117433513(si:ch1073-13h15.3)

PSEX:

120517498(si:ch1073-13h15.3) 120518226

LCM:	102345865 102360472

CMK:

103183764

RTP:	109911920 109924324(si:ch1073-13h15.3)

CPLA:

122539900 122539909

HOC:	132830765 132830774

LERI:

129710311 129710319(si:ch1073-13h15.3)

PMRN:

116940791(RETSAT)

LRJ:	133344556(RETSAT)

BFO:	118424446 118424448 118424619 118429429

BBEL:

109474551 109474647 109482734

CIN:

100179991

SCLV:

120334506 120337475 120338082

SPU:	115919953 581285

LPIC:

129274206

APLC:

110976469

AJC:

117109118

SKO:	100372363 100379022

DPX:	DAPPUDRAFT_191625 DAPPUDRAFT_304083 DAPPUDRAFT_308270

DMK:	116916662 116916664 116922543 116934471 123466462 123470107 123470117

DPZ:	124327058 124342643

PVM:

113802528

PJA:

122246148

PCHN:

125026785

PMOO:

119594827

HAME:

121870663

PCLA:

123775245 123775360

CQD:

128695647

ESN:

126997612

EAF:	111697147 111717702

LSM:

121124288

TCF:

131883878

PPOI:

119113410 119113415 119114328

BMY:	BM_BM288(Bm288)

LOA:	LOAG_09468

HRO:	HELRODRAFT_110282

LGI:	LOTGIDRAFT_198008

PVUL:

126824891

PCAN:

112561339

BGT:

106070286

GAE:	121369279 121369281

HRF:

124151870

HRJ:

124254166

CRG:	105318951 105333941

CVN:	111135672 111135685

CANU:

128188637 128188638

OED:	125667875 125667886

MYI:	110462201 110462205

PMAX:

117332483 117332484

MCAF:

127711322

MMER:

123534024 123534531

RPHI:

132727956 132732222 132751664

DPOL:

127833576

LAK:	106169298 106174680 106174688

NVE:

5515506

EPA:

110244961

ATEN:

116300480

PDAM:

113676513

SPIS:

111331250

DGT:	114517172 114535417

XEN:

124439969

HMG:	100203715 100207416 100211766

HSY:	130623415 130623416 130657656

TAD:	TRIADDRAFT_22982

AQU:

100636736

MBR:	MONBRDRAFT_21832

SRE:	PTSG_08987

SMIN:

v1.2.001388.t1(symbB.v1.2.001388.t1)

TPS:	THAPSDRAFT_10254 THAPSDRAFT_11636

AAF:	AURANDRAFT_25702

SPAR:

SPRG_01865

EHX:	EMIHUDRAFT_450714 EMIHUDRAFT_459817

GTT:	GUITHDRAFT_166294

NGR:	NAEGRDRAFT_81787

» show all

Reference

1 [PMID:15358783]

Authors

Moise AR, Kuksa V, Imanishi Y, Palczewski K

Title

Identification of all-trans-retinol:all-trans-13,14-dihydroretinol saturase.

Journal

J Biol Chem 279:50230-42 (2004)
DOI:10.1074/jbc.M409130200

Sequence

[mmu:67442]

Other DBs

ExplorEnz - The Enzyme Database:

1.3.99.23

IUBMB Enzyme Nomenclature:

1.3.99.23

ExPASy - ENZYME nomenclature database:

1.3.99.23

BRENDA, the Enzyme Database:

1.3.99.23

CAS:	879291-21-1

DBGET integrated database retrieval system