KEGG ENZYME: 1.3.99.32

ENZYME: 1.3.99.32

Entry

EC 1.3.99.32                Enzyme

Name

glutaryl-CoA dehydrogenase (acceptor);
GDHDes;
nondecarboxylating glutaryl-coenzyme A dehydrogenase;
nondecarboxylating glutaconyl-coenzyme A-forming GDH;
glutaryl-CoA dehydrogenase (non-decarboxylating)

Class

Oxidoreductases;
Acting on the CH-CH group of donors;
With unknown physiological acceptors

Sysname

glutaryl-CoA:acceptor 2,3-oxidoreductase (non-decarboxylating)

Reaction(IUBMB)

glutaryl-CoA + acceptor = (E)-glutaconyl-CoA + reduced acceptor [RN:R05579]

Reaction(KEGG)

R05579

Substrate

glutaryl-CoA [CPD:C00527];
acceptor [CPD:C00028]

Product

(E)-glutaconyl-CoA [CPD:C02411];
reduced acceptor [CPD:C00030]

Comment

The enzyme contains FAD. The anaerobic, sulfate-reducing bacterium Desulfococcus multivorans contains two glutaryl-CoA dehydrogenases: a decarboxylating enzyme (EC 1.3.8.6), and a nondecarboxylating enzyme (this entry). The two enzymes cause different structural changes around the glutaconyl carboxylate group, primarily due to the presence of either a tyrosine or a valine residue, respectively, at the active site.

History

EC 1.3.99.32 created 2012, modified 2013

Pathway

ec00362

Benzoate degradation

ec01100

Metabolic pathways

ec01120

Microbial metabolism in diverse environments

Orthology

K16173

glutaryl-CoA dehydrogenase (non-decarboxylating)

Genes

TIG:

THII_2206

GBI:	PG2T_13310

BFN:

OI25_7305

GEM:

GM21_2801

GEO:

Geob_0237

GBM:

Gbem_1452

GBN:	GEOBRER4_29700

GSUB:

KP001_01975

DAL:

Dalk_0058

DAT:	HRM2_38550(acd11) HRM2_38670(acd12)

DTO:	TOL2_C38270(acdA5)

DOV:	DSCO28_15290 DSCO28_44640(acdB_2) DSCO28_67840(acdB_3)

DWD:	DSCW_66360(acdB)

DALK:

DSCA_21130(acdB_1) DSCA_32440(acdB_2) DSCA_37830

DML:	Dmul_25030(acdA5) Dmul_34900(acdA13)

DLI:	dnl_54690(acdA5)

DMM:	dnm_014610(acdA1)

SAT:

SYN_00480

DTI:	Desti_2252 Desti_4873

DBR:

Deba_2447

DMP:	FAK_03800 FAK_40450

HOH:

Hoch_1175

BMYC:

DJ92_4005

BSM:	BSM4216_2477

BFD:	NCTC4823_01481

BACI:

B1NLA3E_10900

BACO:

OXB_1160 OXB_1320

BACA:

FAY30_19300

BAQU:

K6959_09505

BARD:

QRY57_08555

BDA:	FSZ17_11390

OIH:

OB0864

OCN:	CUC15_05285

GKA:

GK0445

GTE:	GTCCBUS3UF5_5600

GTK:	GT3570_02200

GTM:	GT3921_16995

GLI:	GLN3_12655

BCAL:

CWI35_07850

GTN:

GTNG_0452

GWC:	GWCH70_0441

GYC:	GYMC61_1327

GYA:	GYMC52_0449

GCT:	GC56T3_3025

GMC:	GY4MC1_3338

GGH:	GHH_c04660

GJF:	M493_02635

GEA:	GARCT_00480(acdA_1)

GEL:	IB49_12835

GSE:	GT50_12030

GSR:	GS3922_13450

GEJ:	A0V43_18040

GZA:	IC807_15965

GTH:	Geoth_3392

PTL:	AOT13_05790

PTB:	DER53_06815

PCAL:

BV455_01302(acdA_2)

PARG:

PspKH34_33000

AFL:	Aflv_1240(acdA)

AGN:	AFK25_08310

LSP:

Bsph_0858

LGY:	T479_02025

LFU:	HR49_21765

LYS:	LBYS11_02065

LYB:	C3943_02640

LYZ:	DCE79_01535

LPAK:

GDS87_02110

LAGR:

FJQ98_02205

LMAC:

I6G82_16425

LYC:	FH508_0001855

LCAP:

ICJ70_22460

LYP:	MTP04_03100

LIU:	OU989_01835

HHD:	HBHAL_1540 HBHAL_1901

HMN:	HM131_06360 HM131_13220

HLI:

HLI_20160

HNZ:	P9989_16665

HSAN:

MUN89_13145

VIR:	X953_03845

VHL:	BME96_03075

VIG:	BKP57_05365

VIL:	CFK37_02280

VNE:	CFK40_18785

VPN:	A21D_02347(acdA_3)

VIM:	GWK91_11900

VPT:	KBP50_16850

VNT:	OLD84_05440

LAO:	AOX59_10470

LEX:	Len3610_20040

ACOP:

RI196_09345

BSJ:	UP17_06235

BMUR:

ABE28_006370

PBUT:

DTO10_18935

PPSR:

I6J18_08855

PFRI:

L8956_06770

BTHV:

CQJ30_09055

PSYH:

D0S48_09750

PSYO:

PB01_02630

PSYB:

KD050_13765

RUE:	DT065_08935

SALE:

EPH95_09035

POF:	GS400_06975

PCHU:

QNI29_10815

NMK:	CHR53_17165

NTM:	BTDUT50_09765

NDT:	L1999_09955

NCM:	QNK12_18775

MDG:	K8L98_08040

MLIT:

KDJ21_016055

BAG:

Bcoa_0791

BVJ:	I5776_14965

BOU:	I5818_18385

CTHU:

HUR95_05845

GAJ:	MY490_01955 MY490_05105

MJO:	FOF60_12340

SFOR:

QNH23_03565

PUK:	PU629_08505

ANX:	ACH33_15645

ASOC:

CB4_03627(acdA_4)

ATHE:

K3F53_03215

AAC:

Aaci_1850

AAD:	TC41_1948(acd)

AFX:	JZ786_01490

ACUR:

JZ785_18235

ADAU:

NZD86_12865

ACYC:

JI721_05025

BTS:

Btus_0350

KYR:	CVV65_03285

TUM:	CBW65_03605

TAB:	CIG75_03285

EFF:	skT53_18330

SIV:

SSIL_3577

SSIL:

SOLI23_00490

SOB:	CSE16_01720

PLN:	Plano_0640

PKU:	AUO94_13135

PRT:	AUC31_13565

PLL:	I858_003975

PANA:

BBH88_17360

PDG:	BCM40_12500

PHC:	BBI08_16240

PMAR:

B0X71_15560

PPLA:

BBI15_08740

PFAE:

AJGP001_04045

PLX:	CW734_14790

PMAT:

BBI11_14370

PDEC:

H1Q58_13670

KUR:	ASO14_2659

SPSY:

AZE41_20075

SPOR:

SporoP33_11030

SPOP:

SporoP37_11435

SURE:

SporoP32a_11700

SPOS:

DV702_15645

SPAE:

E2C16_04195

SPOO:

J3U78_17690

SURL:

BI350_16275

STHO:

QNH10_00845

PAEK:

D3873_01845

PANC:

E2636_09140 E2636_14105

PLAY:

DNR44_007170

VIJ:	JNUCC6_16920

NTR:	B0W44_03260

TVU:	AB849_000355

PABS:

JIR001_23680

CCB:	Clocel_3947

CLB:	Clo1100_2634

DOR:	Desor_1180 Desor_1198 Desor_2984

DAI:	Desaci_1830

DKU:	Desku_0803 Desku_2606

AACX:

DEACI_1885

DGI:	Desgi_0512 Desgi_4610

CHY:

CHY_1737

LPIL:

LIP_0806

ACIT:

HPK19_11375 HPK19_20125

HHG:	XM38_019870(anaB_1)

MIC:	Mic7113_1750

NOS:	Nos7107_3476

NFL:	COO91_09462

NED:	HUN01_32175

CSG:	Cylst_6469

NCN:	BZZ01_15490 BZZ01_17415

RRS:	RoseRS_2300

RCA:

Rcas_3165

CHL:	Chy400_2879

CAG:

Cagg_0741

HAU:

Haur_1248

CAP:	CLDAP_05970

PBF:	CFX0092_A0325(acdA)

THUG:

KNN16_14240

TTR:

Tter_0362

TRO:

trd_0039

STI:	Sthe_0821 Sthe_1077

FGI:	OP10G_4175

NPY:	NPRO_17230

ABAC:

LuPra_03850(acdA_2)

LUB:	TBR22_A29330

MOX:	DAMO_3029(acdA)

» show all

Reference

1 [PMID:19395484]

Authors

Wischgoll S, Taubert M, Peters F, Jehmlich N, von Bergen M, Boll M

Title

Decarboxylating and nondecarboxylating glutaryl-coenzyme A dehydrogenases in the aromatic metabolism of obligately anaerobic bacteria.

Journal

J Bacteriol 191:4401-9 (2009)
DOI:10.1128/JB.00205-09

Sequence

[ag:ACP50614]

Reference

2 [PMID:20486657]

Authors

Wischgoll S, Demmer U, Warkentin E, Gunther R, Boll M, Ermler U

Title

Structural basis for promoting and preventing decarboxylation in glutaryl-coenzyme a dehydrogenases.

Journal

Biochemistry 49:5350-7 (2010)
DOI:10.1021/bi100317m

Sequence

[ag:ACP50614]

Other DBs

ExplorEnz - The Enzyme Database:

1.3.99.32

IUBMB Enzyme Nomenclature:

1.3.99.32

ExPASy - ENZYME nomenclature database:

1.3.99.32

BRENDA, the Enzyme Database:

1.3.99.32

DBGET integrated database retrieval system