KEGG ENZYME: 1.3.99.37

ENZYME: 1.3.99.37

Entry

EC 1.3.99.37                Enzyme

Name

1-hydroxy-2-isopentenylcarotenoid 3,4-desaturase;
crtD (gene name)

Class

Oxidoreductases;
Acting on the CH-CH group of donors;
With unknown physiological acceptors

Sysname

dihydroisopentenyldehydrorhodopin:acceptor 3,4-oxidoreductase

Reaction(IUBMB)

(1) dihydroisopentenyldehydrorhodopin + acceptor = isopentenyldehydrorhodopin + reduced acceptor [RN:R12708];
(2) dihydrobisanhydrobacterioruberin + acceptor = bisanhydrobacterioruberin + reduced acceptor [RN:R12709]

Reaction(KEGG)

R12708 R12709

Substrate

dihydroisopentenyldehydrorhodopin [CPD:C22058];
acceptor [CPD:C00028];
dihydrobisanhydrobacterioruberin [CPD:C22060]

Product

isopentenyldehydrorhodopin [CPD:C22059];
reduced acceptor [CPD:C00030];
bisanhydrobacterioruberin [CPD:C22347]

Comment

The enzyme, isolated from the archaeon Haloarcula japonica, is involved in the biosynthesis of the C50 carotenoid bacterioruberin. In this pathway it catalyses the desaturation of the C-3,4 double bond in dihydroisopentenyldehydrorhodopin and the desaturation of the C-3',4' double bond in dihydrobisanhydrobacterioruberin.

History

EC 1.3.99.37 created 2015

Pathway

ec00906

Carotenoid biosynthesis

ec01100

Metabolic pathways

ec01110

Biosynthesis of secondary metabolites

Orthology

K20611

1-hydroxy-2-isopentenylcarotenoid 3,4-desaturase

Genes

SHUA:

PQ477_16765(crtI)

RMF:	D5E69_12835(crtI)

SASS:

MUG09_14445(crtI)

ANF:

AQPE_1616

MTH:

MTH_1807

MMG:	MTBMA_c03770

MWO:	MWSIV6_0338(crtD)

METC:

MTCT_1646

METE:

tca_01745(crtN)

METK:

FVF72_02665(crtI)

MTHM:

FZP57_01580(crtI)

METJ:

FZP68_06595(crtI)

MEME:

HYG87_02230(crtI) HYG87_08505(crtI)

MZH:	Mzhil_0948

MEM:	Memar_0116

MSUM:

OH143_07370(crtI)

MAQE:

RJ40_05275(crtI)

MFK:	E2N92_05475(crtI)

HAL:	VNG_1684G(crtI1) VNG_1755G(crtI2)

HSL:	OE_3381R(crtI1) OE_3468R(crtI2)

HANR:

LJ422_06800(crtI) LJ422_07070(crtI)

HDL:	HALDL1_13230

HHB:	Hhub_3180(crtI)

HAGS:

JT689_08130(crtI) JT689_08410(crtI)

HABO:

JRZ79_06545(crtI) JRZ79_06820(crtI)

HNO:	LT974_11795(crtI)

HLU:	LT972_03115(crtI)

HALH:

HTSR_0322(crtI)

HHSR:

HSR6_0308(crtI)

HSU:	HLASF_0240(crtI)

HSF:	HLASA_0240(crtI)

HAHS:

HSRCO_0377

SALR:

FQU85_06785(crtI)

HALR:

EFA46_012300(crtI)

HJE:	HacjB3_05880

HDO:	MUK72_08390(crtI)

HALX:

M0R89_12790(crtI)

HAXZ:

M0R88_12935(crtI)

HAYC:

NGM10_02410(crtI)

SALI:

L593_04765

SAIM:

K0C01_03165(crtI) K0C01_06230(crtI)

HARA:

AArcS_2785 AArcS_2862

HMA:	rrnAC0321(crtI2) rrnAC1902(crtI1)

HHI:	HAH_1058(crtI1) HAH_2415(crtI2)

HHN:	HISP_05435 HISP_12295

HAB:	SG26_04610 SG26_13105

HTA:	BVU17_05180 BVU17_11750

HALJ:

G9465_16515(crtI)

HSIN:

KDQ40_01355(crtI) KDQ40_08200(crtI)

NPH:	NP_0204A(crtI2) NP_4764A(crtD)

NMO:	Nmlp_3026(crtI1) Nmlp_3576(crtI2)

NHO:	HWV23_16745(crtI)

NSAL:

HWV07_18225(crtI)

HUT:	Huta_0318 Huta_2373

HTI:	HTIA_0507 HTIA_2106

HALA:

Hrd1104_01365(crtI) Hrd1104_03715(crtI)

HASV:

SVXHr_1253(crtD) SVXHr_2183(crtD2)

HABN:

HBNXHr_1237(crtD) HBNXHr_2179(crtD2)

HMU:	Hmuk_1360 Hmuk_1684

HALZ:

E5139_09960(crtI) E5139_11545(crtI)

HALL:

LC1Hm_0581

HAZP:

GBQ70_09955(crtI) GBQ70_11540(crtI)

HALI:

BV210_13215

HSN:	DV733_06795(crtI) DV733_07110(crtI)

HDS:	HSR122_0174 HSR122_2630

HRR:	HZS55_20285(crtI)

HPEL:

HZS54_23770(crtI)

HLT:	I7X12_05360(crtI) I7X12_14750(crtI)

HARC:

HARCEL1_04560 HARCEL1_05665

SSAI:

N0B31_09240(crtI) N0B31_19490(crtI)

HAAD:

MW046_14460(crtI)

HWA:	HQ_1794A(crtI2) HQ_2863A(crtD)

HWC:	Hqrw_1930(crtI2) Hqrw_3257(crtD)

HVO:	HVO_2528(crtI)

HME:

HFX_2550

HGI:	ABY42_12670

HALE:

G3A49_16065(crtI)

HLS:	KU306_00320(crtI)

HLN:	SVXHx_2072(crti)

HBO:	Hbor_10650

HAQ:	DU484_15070(crtI)

HAJ:	DU500_15100(crtI)

HAER:

DU502_13080(crtI)

HRA:	EI982_09630(crtI) EI982_16645(crtI)

HLM:	DV707_06355(crtI)

HALM:

FCF25_03150(crtI)

HLA:

Hlac_1897

HALP:

DOS48_09165

HALB:

EKH57_01630(crtI) EKH57_08510(crtI)

HEZZ:

EO776_04010(crtI) EO776_05030(crtI) EO776_09980(crtI)

HALQ:

Hrr1229_002465(crtI) Hrr1229_002950(crtI) Hrr1229_010285(crtI)

HSS:	J7656_06535(crtI) J7656_11800(crtI) J7656_12845(crtI)

HSAI:

HPS36_01735(crtI) HPS36_03195(crtI) HPS36_12055(crtI)

HAZZ:

KI388_01465(crtI) KI388_02585(crtI) KI388_07990(crtI)

SRUB:

C2R22_15240

HAE:	halTADL_0469

HALN:

B4589_011160(crtI)

HALG:

HUG10_00795(crtI)

HALU:

HUG12_16785(crtI)

HMP:	K6T50_14385(crtI)

HRE:	K6T36_14335(crtI)

HRM:	K6T25_02470(crtI) K6T25_12720(crtI)

HACB:

Hbl1158_06180(crtI) Hbl1158_16020(crtI)

HDF:	AArcSl_1205(crtD) AArcSl_2786

HAH:	Halar_2115

HTU:

Htur_2704

HSAL:

JMJ58_15350(crtI)

HAKZ:

J0X25_02315(crtI)

NMG:	Nmag_1001(crtI)

HXA:	Halxa_2222

NAT:

NJ7G_1612

NPE:	Natpe_1081

NVR:	FEJ81_05640(crtI)

NPL:	FGF80_05295(crtI)

NAY:	HYG81_05200(crtI)

HALY:

HYG82_06630(crtI)

HJT:	DVR14_14705(crtI)

HLO:	J0X27_13920(crtI)

NGE:	Natgr_2200

HRU:	Halru_1199

SAWL:

NGM29_09970(crtI)

HALV:

NGM15_02175(crtI)

NOU:	Natoc_1917

HLR:	HALLA_16025

HLC:	CHINAEXTREME08695 CHINAEXTREME13560

NAJ:	B1756_14580

NAG:	AArcMg_0573 AArcMg_2863

NAN:	AArc1_0585 AArc1_0840

NARA:

QQ977_09750(crtI)

NBG:	DV706_10185(crtI)

NAS:	GCU68_01890(crtI)

HDA:	BB347_07035 BB347_09725

CDIV:

CPM_0973

CSTY:

KN1_09430

PAS:

Pars_0409

POG:

Pogu_1958

PYW:	PYWP30_01285

CSU:	CSUB_C0582

» show all

Reference

1 [PMID:25712483]

Authors

Yang Y, Yatsunami R, Ando A, Miyoko N, Fukui T, Takaichi S, Nakamura S

Title

Complete biosynthetic pathway of the C50 carotenoid bacterioruberin from lycopene in the extremely halophilic archaeon Haloarcula japonica.

Journal

J Bacteriol 197:1614-23 (2015)
DOI:10.1128/JB.02523-14

Sequence

[ag:BAP82509]

Other DBs

ExplorEnz - The Enzyme Database:

1.3.99.37

IUBMB Enzyme Nomenclature:

1.3.99.37

ExPASy - ENZYME nomenclature database:

1.3.99.37

BRENDA, the Enzyme Database:

1.3.99.37

DBGET integrated database retrieval system