KEGG ENZYME: 1.4.1.19

ENZYME: 1.4.1.19

Entry

EC 1.4.1.19                 Enzyme

Name

tryptophan dehydrogenase;
NAD(P)+-L-tryptophan dehydrogenase;
L-tryptophan dehydrogenase;
L-Trp-dehydrogenase;
TDH

Class

Oxidoreductases;
Acting on the CH-NH2 group of donors;
With NAD+ or NADP+ as acceptor

Sysname

L-tryptophan:NAD(P)+ oxidoreductase (deaminating)

Reaction(IUBMB)

L-tryptophan + NAD(P)+ + H2O = (indol-3-yl)pyruvate + NH3 + NAD(P)H + H+ [RN:R00675 R00676]

Reaction(KEGG)

R00675 R00676;
(other) R00145 R00146

Substrate

L-tryptophan [CPD:C00078];
NAD+ [CPD:C00003];
NADP+ [CPD:C00006];
H2O [CPD:C00001]

Product

(indol-3-yl)pyruvate [CPD:C00331];
NH3 [CPD:C00014];
NADH [CPD:C00004];
NADPH [CPD:C00005];
H+ [CPD:C00080]

Comment

Activated by Ca2+.

History

EC 1.4.1.19 created 1989

Reference

Authors

Vackova, K., Mehta, A. and Kutacek, M.

Title

Tryptophan aminotransferase and tryptophan dehydrogenase - activities in some cell compartments of spinach leaves - the effect of calcium-ions on tryptophan dehydrogenase.

Journal

Biol Plant 27:154-158 (1985)

Other DBs

ExplorEnz - The Enzyme Database:

1.4.1.19

IUBMB Enzyme Nomenclature:

1.4.1.19

ExPASy - ENZYME nomenclature database:

1.4.1.19

BRENDA, the Enzyme Database:

1.4.1.19

CAS:	94047-13-9

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