KEGG ENZYME: 1.4.1.25

ENZYME: 1.4.1.25

Entry

EC 1.4.1.25                 Enzyme

Name

L-arginine dehydrogenase;
dauB (gene name);
anabolic L-arginine dehydrogenase

Class

Oxidoreductases;
Acting on the CH-NH2 group of donors;
With NAD+ or NADP+ as acceptor

Sysname

L-arginine:NAD(P)+ oxidoreductase (deaminating)

Reaction(IUBMB)

L-arginine + H2O + NAD(P)+ = 5-guanidino-2-oxopentanoate + NH3 + NAD(P)H + H+ [RN:R11031 R11032]

Reaction(KEGG)

R11031 R11032

Substrate

L-arginine [CPD:C00062];
H2O [CPD:C00001];
NAD+ [CPD:C00003];
NADP+ [CPD:C00006]

Product

5-guanidino-2-oxopentanoate [CPD:C03771];
NH3 [CPD:C00014];
NADH [CPD:C00004];
NADPH [CPD:C00005];
H+ [CPD:C00080]

Comment

The enzyme, which has been isolated from the bacterium Pseudomonas aeruginosa PAO1, forms with EC 1.4.99.6, D-arginine dehydrogenase, a two-enzyme complex involved in the racemization of D- and L-arginine.

History

EC 1.4.1.25 created 2017

Pathway

ec00470

D-Amino acid metabolism

ec01100

Metabolic pathways

Orthology

K19744

L-arginine dehydrogenase

Genes

PALH:

B1H58_18955

PPR:	PBPRB0030(PA3862)

PAE:	PA3862(dauB)

PAEV:

N297_3988

PAEI:

N296_3988

PAU:	PA14_14020

PAP:	PSPA7_1243

PAG:	PLES_11121

PAF:	PAM18_1076

PNC:	NCGM2_5052

PAEB:

NCGM1900_1111

PDK:	PADK2_05005

PSG:	G655_05385

PRP:	M062_20420

PAEP:

PA1S_05510

PAER:

PA1R_gp1756

PAEM:

U769_05545

PAEL:

T223_05460

PAES:

SCV20265_1135

PAEU:

BN889_04293

PAEG:

AI22_28105

PAEC:

M802_3986

PAEO:

M801_3854

PMY:

Pmen_3566

PRE:	PCA10_11000

PFUW:

KF707C_10270

PALC:

A0T30_06955

PMUI:

G4G71_09100

PNT:	G5B91_26035

PPAA:

B7D75_05425

PFL:

PFL_1045

PPRC:

PFLCHA0_c10640

PPRO:

PPC_1082

PFE:	PSF113_4742

PFO:	Pfl01_0970

PFC:	PflA506_2228

PFB:

VO64_5502

PMAN:

OU5_2435

PTV:	AA957_03145

PCG:	AXG94_09920

PVR:	PverR02_12350

PAZO:

AYR47_18380

PRX:	HRH33_11185

PMED:

E3Z27_23060

PKR:	AYO71_07590

PFW:	PF1751_v1c20450

PFF:	PFLUOLIPICF726490

PFX:	A7318_09935

PBA:	PSEBR_a4580

PBC:	CD58_24250

PPUU:

PputUW4_04461

PDR:	H681_19275

PSK:	U771_12280

PKC:

PKB_0989

PCH:	EY04_04570

PCZ:	PCL1606_50590

PCP:	JM49_25075

PCHP:

C4K32_1113

PALK:

PSAKL28_08840

PSEM:

TO66_05260

PSOS:

POS17_1042

PFK:	PFAS1_16745

PANR:

A7J50_2221

PSET:

THL1_1153

PSIL:

PMA3_04250

PKE:	DLD99_05210

PUM:	HGP31_04845

POJ:	PtoMrB4_46060(dauB)

PGY:	AWU82_19030 AWU82_29060

PLAL:

FXN65_05125

PVK:	EPZ47_24275

PBZ:	GN234_24070

PATA:

JWU58_22700

PDW:	BV82_4677C

PZE:	HU754_006325

PMOE:

HV782_005900

PCAM:

HNE05_02895

PSEP:

C4K39_1054

PPII:

QL104_05235

PVW:	HU752_020810

PTRT:

HU722_0011760

PSAM:

HU731_027915

PTZ:	HU718_005960

PQI:	KH389_22200

PHV:	HU739_012660

PPRG:

HU725_013415

PAZE:

KSS91_23795

PALV:

KSS97_06345

PORY:

EJA05_04850

PTK:	EXN22_22875

PTW:	TUM18999_49970(dauB)

PZA:	HU749_024085

PIE:	HU724_005725

PGF:	J0G10_06125

PHF:	NLY38_20290

PIZ:	LAB08_R50310

PPEG:

KUA23_18535

PSII:

NF676_05395

PSIH:

LOY51_04750

PCAS:

LOY40_05280 LOY40_17935

PFIT:

KJY40_05985

PNB:	NK667_22285

PSOA:

PSm6_09800(dauB)

PKJ:	Q1W70_05420

PHOM:

KJF94_21230

PCUC:

PSH97_23065

PTRL:

OU419_22390

PPAE:

LDL65_21670

PRHZ:

CRX69_09255

PDEN:

F1C79_17795

THAT:

H3N35_19390

TACT:

SG35_020515

TVD:	SG34_008640

ORB:	IPMB12_01150

VOG:	LCH97_01975

BUR:	Bcep18194_A3938

BCM:	Bcenmc03_0820

BCH:	Bcen2424_0848

BCJ:

BCAL3157

BCEN:

DM39_657

BCEW:

DM40_1511

BCEO:

I35_0706

BAM:

Bamb_0723

BAC:	BamMC406_0740

BMJ:	BMULJ_00699

BMU:

Bmul_2539

BMK:

DM80_839

BMUL:

NP80_860

BCT:

GEM_2683

BCED:

DM42_982

BCEP:

APZ15_07875

BDL:

AK34_2328

BPYR:

ABD05_09845

BCON:

NL30_11560

BDF:	WI26_03730

BLAT:

WK25_03945

BTEI:

WS51_14505

BSEM:

WJ12_03835

BPSL:

WS57_21640

BMEC:

WJ16_03870

BSTG:

WT74_04145

BSTL:

BBJ41_07940

BANN:

JFN94_04020

BARI:

NLX30_04155

BAEN:

L3V59_04145

BUG:	BC1001_3931

BYI:	BYI23_C013410

BUE:	BRPE67_CCDS13080

BUQ:	AC233_21940

BURK:

DM992_17370

BPH:

Bphy_3431

BGE:	BC1002_4530

BPX:	BUPH_00515

BPY:	Bphyt_2072

BUZ:	AYM40_32340

BFN:

OI25_6281

BCAI:

K788_0007543

PHS:	C2L64_22690

PTER:

C2L65_24905

PGP:	CUJ91_21585

PCJ:	CUJ87_22380

PTS:	CUJ90_24110

PCAF:

DSC91_002143

PTRO:

G5S35_15200

PSAA:

QEN71_12465

PPAI:

E1956_18045

CABK:

NK8_47300

TVL:	FAZ95_34320

EAD:	OV14_b1239

EAH:	FA04_28125

REL:	REMIM1_PC00033

SHZ:

shn_32355

ABAW:

D5400_18045

MOC:	BB934_32250

MTEZ:

HPT29_027530

AUZ:	Sa4125_45440(dauB)

CAUL:

KCG34_07640

SULZ:

C1J03_09690

SEDI:

EBB79_04115

SMAG:

AN936_14040

SMAZ:

LH19_04515

SECH:

B18_02355

STRE:

GZL_01015

MCRA:

ID554_30815

» show all

Reference

1 [PMID:19139398]

Authors

Li C, Lu CD

Title

Arginine racemization by coupled catabolic and anabolic dehydrogenases.

Journal

Proc Natl Acad Sci U S A 106:906-11 (2009)
DOI:10.1073/pnas.0808269106

Sequence

[pae:PA3862]

Other DBs

ExplorEnz - The Enzyme Database:

1.4.1.25

IUBMB Enzyme Nomenclature:

1.4.1.25

ExPASy - ENZYME nomenclature database:

1.4.1.25

BRENDA, the Enzyme Database:

1.4.1.25

DBGET integrated database retrieval system