Entry
Name
2,4-diaminopentanoate dehydrogenase (NAD+);
DAPDH (ambiguous)
Class
Oxidoreductases;
Acting on the CH-NH2 group of donors;
With NAD+ or NADP+ as acceptor
BRITE hierarchy
Sysname
(2R,4S)-2,4-diaminopentanoate:NADP+ oxidoreductase (deaminating)
Reaction(IUBMB)
(2R,4S)-2,4-diaminopentanoate + H2O + NAD+ = (2R)-2-amino-4-oxopentanoate + NH3 + NADH + H+ [RN:
R04200 ]
Reaction(KEGG)
Substrate
Product
Comment
The enzyme, characterized from an unknown bacterium in an environmental sample, has some activity with (2R,4R)-2,4-diaminopentanoate. It has very low activity with NADP+ (cf. EC
1.4.1.12 , 2,4-diaminopentanoate dehydrogenase).
History
EC 1.4.1.26 created 2017
Pathway
Orthology
K21672 2,4-diaminopentanoate dehydrogenase
Genes
CACE : CACET_c17480(dapB2)
CTAG : LL095_13645 LL095_13650
PDF : CD630DERM_04420(ord)
» show all
Taxonomy
Reference
Authors
Fonknechten N, Perret A, Perchat N, Tricot S, Lechaplais C, Vallenet D, Vergne C, Zaparucha A, Le Paslier D, Weissenbach J, Salanoubat M
Title
A conserved gene cluster rules anaerobic oxidative degradation of L-ornithine.
Journal
Sequence
Other DBs
ExplorEnz - The Enzyme Database: 1.4.1.26
ExPASy - ENZYME nomenclature database: 1.4.1.26