Entry
Name
Class
Oxidoreductases;
Acting on the CH-NH2 group of donors;
With oxygen as acceptor
BRITE hierarchy
Sysname
L-arginine:oxygen oxidoreductase (deaminating)
Reaction(IUBMB)
L-arginine + H2O + O2 = 5-guanidino-2-oxopentanoate + NH3 + H2O2 [RN:
R11604 ]
Reaction(KEGG)
Substrate
Product
Comment
Contains FAD. The enzyme from cyanobacteria can also act on other basic amino acids with lower activity. The enzyme from the bacterium Pseudomonas sp. TPU 7192 is highly specific.
History
EC 1.4.3.25 created 2017
Pathway
ec00330 Arginine and proline metabolism
Orthology
Genes
LAVI : INQ42_12295 INQ42_12305
Taxonomy
Reference
Authors
Miller DL, Rodwell VW
Title
Metabolism of basic amino acids in Pseudomonas putida. Intermediates in L-arginine catabolism.
Journal
J Biol Chem 246:5053-8 (1971)
Reference
Authors
Pistorius EK, Voss H
Title
Some properties of a basic L-amino-acid oxidase from Anacystis nidulans.
Journal
Reference
Authors
Gau AE, Heindl A, Nodop A, Kahmann U, Pistorius EK
Title
L-amino acid oxidases with specificity for basic L-amino acids in cyanobacteria.
Journal
Sequence
Reference
Authors
Matsui D, Terai A, Asano Y
Title
L-Arginine oxidase from Pseudomonas sp. TPU 7192: Characterization, gene cloning, heterologous expression, and application to L-arginine determination.
Journal
Other DBs
ExplorEnz - The Enzyme Database: 1.4.3.25
ExPASy - ENZYME nomenclature database: 1.4.3.25