KEGG   ENZYME: 1.4.3.26
Entry
EC 1.4.3.26                 Enzyme                                 
Name
pre-mycofactocin synthase;
mftD (gene name)
Class
Oxidoreductases;
Acting on the CH-NH2 group of donors;
With oxygen as acceptor
Sysname
3-amino-5-[(4-hydroxyphenyl)methyl]-4,4-dimethylpyrrolidin-2-one:oxygen oxidoreductase
Reaction(IUBMB)
3-amino-5-[(4-hydroxyphenyl)methyl]-4,4-dimethylpyrrolidin-2-one + O2 + H2O = 5-[(4-hydroxyphenyl)methyl]-4,4-dimethylpyrrolidine-2,3-dione + NH3 + H2O2 (overall reaction) [RN:R12684];
(1a) 3-amino-5-[(4-hydroxyphenyl)methyl]-4,4-dimethylpyrrolidin-2-one + O2 = 5-[(4-hydroxyphenyl)methyl]-3-imino-4,4-dimethylpyrrolidin-2-one + H2O2 [RN:R12685];
(1b) 5-[(4-hydroxyphenyl)methyl]-3-imino-4,4-dimethylpyrrolidin-2-one + H2O = 5-[(4-hydroxyphenyl)methyl]-4,4-dimethylpyrrolidine-2,3-dione + NH3 (spontaneous) [RN:R12686]
Reaction(KEGG)
Substrate
3-amino-5-[(4-hydroxyphenyl)methyl]-4,4-dimethylpyrrolidin-2-one [CPD:C22330];
O2 [CPD:C00007];
H2O [CPD:C00001];
5-[(4-hydroxyphenyl)methyl]-3-imino-4,4-dimethylpyrrolidin-2-one [CPD:C22332]
Product
5-[(4-hydroxyphenyl)methyl]-4,4-dimethylpyrrolidine-2,3-dione [CPD:C22331];
NH3 [CPD:C00014];
H2O2 [CPD:C00027];
5-[(4-hydroxyphenyl)methyl]-3-imino-4,4-dimethylpyrrolidin-2-one [CPD:C22332]
Comment
A flavoprotein (FMN). The enzyme participates in the biosynthesis of the enzyme cofactor mycofactocin. The enzyme uses oxygen as an electron source to oxidize a C-N bond, followed by spontaneous exchange with water to form an alpha-keto moiety on the resulting molecule.
History
EC 1.4.3.26 created 2020
Orthology
K24693  pre-mycofactocin synthase
Genes
MTURv0694
MTVRVBD_0694
MTCMT0721
MRAMRA_0702(lldD1)
MTFTBFG_10708
MTBTBMG_00707
MTKTBSG_00711
MTZTBXG_000700
MTIMRGA423_04330
MTECCDC5079_0645
MTURCFBS_0730(lldD1)
MTLCCDC5180_0636
MTOMTCTRI2_0710(lldD1)
MTDUDA_0694(lldD1)
MTNERDMAN_0766(lldD1)
MTJJ112_03715
MTUBMT7199_0712
MTUEJ114_03705
MTXM943_03610
MTUHI917_04945
MTULTBHG_00689
MTUTHKBT1_0730(lldD1)
MTUUHKBT2_0731(lldD1)
MTQHKBS1_0730(lldD1)
MBOBQ2027_MB0713(lldD1)
MBBBCG_0743(lldD1)
MBTJTY_0713(lldD1)
MBMBCGMEX_0714(lldD1)
MBKK60_007400
MBXBCGT_0486
MAFMAF_07030(lldD1)
MMICRN08_0774
MCEMCAN_06951(lldD1)
MCQBN44_10764(lldD)
MCVBN43_20126(lldD)
MCXBN42_20449(lldD)
MCZBN45_10794(lldD)
MORYMO_000739(mftD)
MPAMAP_4154(lldD1)
MAOMAP4_4280
MAVIRC58_21260
MAVURE97_21310
MAVMAV_4477
MITOCO_43680
MIAOCU_43440
MIDMIP_06628
MYOOEM_43910
MCHIAN480_22765
MIROCQ_44790
MMALCKJ54_20790
MLPMLM_3633
MMANMMAN_31910
MSAMycsm_00994
MULMUL_0774(lldD1)
MMIMMAR_1022(lldD1)
MMAEMMARE11_09750(lldD1)
MLIMULP_01149(lldD1)
MPSEMPSD_11590(lldD1)
MSHOMSHO_28110(mftD)
MMCMmcs_1002
MKMMkms_1019
MJLMjls_1029
MMMW7S_22020
MKNMKAN_19595
MYVG155_07140
MYEAB431_05555
MHADB586_18790
MDXBTO20_28585
MSHGMSG_00883(mftD)
MFJMFLOJ_25790(mftD)
MSTOMSTO_29430(lldD1)
MSIMMSIM_16070(mftD)
MSAKMSAS_44580(lldD1)
MKUI2456_05205(mftD)
MLWMJO58_04705(mftD)
MXEMYXE_39980(mftD)
MNVMNVI_25250(mftD)
MPAGC0J29_05585
MNMMNVM_27260
MGORH0P51_05080(mftD)
MCOOMCOO_41770(mftD)
MBAIMB901379_00883(lldD_1)
MSEOMSEO_48260(mftD)
MHEKJMUB5695_03903(mftD)
MGAUMGALJ_54740(mftD)
MLJMLAC_34940(mftD)
MBRDMBRA_06480(lldD1)
MSHJMSHI_27510(lldD1)
MMAMK3U93_04270(mftD)
MSPGF6B93_04320(mftD)
MOTLTS72_20555(mftD)
MPAAMKK62_01645(mftD) MKK62_20120(mftD)
MMEHM5I08_21205(mftD)
MKYIWGMT90018_10160
MADIA7U43_25305
MWUPT015_22330(mftD)
MSMMSMEG_1424
MSGMSMEI_1389(lldD1)
MSBLJ00_07100
MSNLI99_07100
MSHLI98_07100
MVAMvan_1297
MGIMflv_5059
MSPMspyr1_44770
MCBMycch_0935 Mycch_5885
MNED174_06610
MYNMyAD_06475
MFTXA26_14280
MPHLMPHLCCUG_01294(lldD)
MVQMYVA_1102
MLLB1R94_05280 B1R94_22380
MRHMycrhN_0707 MycrhN_3065
MTHN4412656_00904(lldD)
MHASMHAS_00223(mftD)
MDUMDUV_34200
MCHTMCHIJ_01190
MDRMDOR_06290
MAUUNCTC10437_01080(lldD)
MMAGMMAD_11160
MMORMMOR_54170(mftD)
MFXMFAL_21350
MAICMAIC_45860
MIJMINS_13340
MALVMALV_24320
MTYMTOK_31930
MPSCMPSYJ_14440(lldD1) MPSYJ_53840
MARZMARA_27870
MGADMGAD_28130(lldD1)
MHEVMHEL_11870
MSARMSAR_25560
MANYMANY_39930 MANY_49640 MANY_50610(mftD)
MAUBMAUB_22110
MPOFMPOR_01030(lldD1) MPOR_15790
MPHUMPHO_48450
MMUCC1S78_023000(mftD)
MMATMMAGJ_31380(mftD) MMAGJ_42620
MBOKMBOE_62320
MFGK6L26_25500(mftD)
MSEIMSEDJ_23780
MFLVNCTC10271_04119(lldD)
MCEEMCEL_23180
MMONEWR22_05395(mftD)
MGOAFA91_31795
MHOLK3U96_21200(mftD)
MSENK3U95_06220(mftD)
MPAEK0O64_05090(mftD)
MRFMJO55_05340(mftD) MJO55_24970(mftD)
MDFK0O62_05975(mftD)
MCROMI149_05815(mftD)
MGROFZ046_11355(mftD)
MKRMKOR_22770
MPAKMIU77_15070(mftD)
MABMAB_3834c
MMVMYCMA_2120
MABBMASS_3845
MABLMMASJCM_3849
MCHEBB28_19630
MIZBAB75_21905
MSTEMSTE_03983
MSAOMYCSP_17700
MSALDSM43276_03627(lldD)
MJDJDM601_3347(lldD1)
MTER4434518_03334(lldD1)
MMINMMIN_10490
MHIBMHIB_27750
MHERK3U94_19115(mftD)
MVMMJO54_19080(mftD)
ASDAS9A_4329 AS9A_4369
NFANFA_22320 NFA_32080
NFRERS450000_00862(lldD_1) ERS450000_01865(lldD_2)
NCYNOCYR_3384
NNONONO_c43720
NOZDMB37_06070(mftD)
NAHF5544_26880(mftD)
NADNCTC11293_04501(lldD)
NWLNWFMUON74_31330
NGPLTT66_26875(mftD)
NSPUIFM12276_22320(lldD1)
RHARHA1_ro06073
RERRER_18000
REYO5Y_08635
REBXU06_08875
RQIC1M55_09110
ROPROP_61310
ROAPd630_LPD02714
RPYY013_08770
RBYCEJ39_19665
RHBNY08_1951
RAVAAT18_18585
RFAA3L23_00296(mftD_2)
RHSA3Q41_03118(mftD_1)
RHWBFN03_03200
RRZCS378_08055
RHUA3Q40_00413(mftD)
RHQIM25_00600
RHODAOT96_19475
RRT4535765_03564(lldD)
RCRNCTC10994_03688(mdlB)
RTMG4H71_16290(mftD)
RKOJWS14_33115(mftD)
RGOKYT97_09555(mftD)
ROZCBI38_20390
RPSKJWS13_10845(mftD)
RGORNMQ04_15525(mftD)
RANTRHODO2019_14315(mftD) RHODO2019_14320(mftD)
RHOPD8W71_12600(mftD) D8W71_12605(mftD)
REQREQ_36260
PDEFP9209_16160(mftD)
WHROG579_07505(mftD)
GBRGbro_3777
GPOGPOL_c36470
GORKTR9_3736
GOQACH46_15910
GTABCM27_19565
GOCCXX93_06960
GITC6V83_16210(mftD)
GRUGCWB2_19175(lldD)
GOMD7316_04927(mftD)
GAVC5O27_08965(mftD)
GODGKZ92_18105(mftD)
GAMGII34_18045(mftD)
GPDGII33_17500(mftD)
GJIH1R19_17925(mftD)
GOILK459_15810(mftD)
GHNMVF96_18490(mftD)
GAMIIHQ52_22080(mftD)
GMGNWF22_03540(mftD)
GSIP5P27_15280(mftD)
SPINKV203_02220(mftD)
TSMASU32_04095
TSDMTP03_02830
DTMBJL86_2335
DITC3V38_01375(mftD)
DIZCT688_11590
DPCA6048_12170
DLUA6035_11190
DKNNHB83_11610(mftD)
TOYFO059_05815(mftD)
SHYSHJG_2442
SHOSHJGH_2207
SBROGQF42_07990(mftD)
STUIGCM10017668_53910
SPRACP972_11020(mftD)
SCIRSTRCI_007930(mftD)
SANTQR300_11385(mftD)
YIALO772_03295(mftD)
MSEDE3O41_00715(mftD)
MCAWF6J84_03085(mftD)
MELYL2X98_23820(mftD)
FSBGCM10025867_43720
AARCG127AT_05870(mftD)
AMAVGCM10025877_11550(mftD)
CPHYB5808_07305
CHREIE160_02970(mftD)
HUMDVJ78_13580(mftD)
LTREVS81_11980(mftD)
LALLMUN78_01460(mftD)
LRPMUN76_06410(mftD)
HEAHL652_05855(mftD)
HEHL3i23_13060(lldD1)
SUBALQ955_15000(mftD)
AJGKKR91_08560(mftD)
AZXN2K95_07770(mftD)
AJRN2K98_08380(mftD)
BEIGCM100_01110
JLIEXU32_11040(mftD)
JAYH7A72_14565(mftD)
NDPE2C04_03205(mftD)
NAROCFH99_21860 CFH99_24465
NAQUENKNEFLB_00510(mftD)
NROK8W59_04735(mftD)
NPCKUV85_09745(mftD)
NPSKRR39_16375(mftD)
NMARHPC71_02605
PSIMKR76_00720 KR76_24780
AEZC3E78_15425(mftD)
AEBC6I20_03060(mftD)
AEFGEV26_02915(mftD)
NBTKLP28_13000(mftD)
TFUTfu_2980
THAONI17_018885(mftD)
TALXFOF52_16185(mftD)
SAIUJ4H86_09355(mftD)
TCUTcur_2361
ACTWF7P10_02080(mftD)
AMAZLUW76_43945(mftD)
FREFranean1_3205
FALFRAAL3579
NMLNamu_0776
NAKAH7F38_19405(mftD)
GOBGobs_0573
BSDBLASA_4816
MMARMODMU_5387(lldD)
SENSACE_2390(lldD1)
SACGFDZ84_25660(mftD) FDZ84_29570(mftD) FDZ84_34695(mftD)
AMQAMETH_2163(lldD1)
AMYCCU254_14340
APRTMUY14_18335(mftD)
AROONQK81_28205(mftD)
ATHML1857_13410(mftD)
ARHDVSH64_10225(mftD)
PDXPsed_4052
PSEAWY02_22925
PSEEFRP1_19815
PSEHXF36_04020
PSEQAD006_27230
PECQAD017_06825
PHHAFB00_18590
PAUTPdca_15250
PBROHOP40_01230(mftD)
PPELH6H00_24630(mftD)
KBUQ4V64_47340(mftD)
ALOCRK56115
PMADBAY61_16740
ACTYOG774_18855(mftD)
ASEACPL_6088
AMSAMIS_27210
ACTSACWT_5956
ACTLL3i22_048290 L3i22_048330(mftD)
CATICS0771_62040(mftD)
DROSDrose_15385(mftD)
EKEEK0264_02670(mftD)
RXYRxyl_3151
RRDRradSPS_2637
RMARGBA65_20425(mftD)
SBAEDSM104329_01720(mftD)
AYMYM304_36360
AQZKSP35_11425(mftD)
IAMHC251_02950(mftD)
TROtrd_A0844
STISthe_2860
MICAP0L94_00220(mftD)
 » show all
Reference
1  [PMID:31381312]
  Authors
Ayikpoe RS, Latham JA.
  Title
MftD Catalyzes the Formation of a Biologically Active Redox Center in the Biosynthesis of the Ribosomally Synthesized and Post-translationally Modified Redox Cofactor Mycofactocin.
  Journal
J Am Chem Soc 141:13582-13591 (2019)
DOI:10.1021/jacs.9b06102
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 1.4.3.26
IUBMB Enzyme Nomenclature: 1.4.3.26
ExPASy - ENZYME nomenclature database: 1.4.3.26
BRENDA, the Enzyme Database: 1.4.3.26

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