Entry
Name
thiomorpholine-carboxylate dehydrogenase;
ketimine reductase;
ketimine-reducing enzyme
Class
Oxidoreductases;
Acting on the CH-NH group of donors;
With NAD+ or NADP+ as acceptor
BRITE hierarchy
Sysname
thiomorpholine-3-carboxylate:NAD(P)+ 5,6-oxidoreductase
Reaction(IUBMB)
thiomorpholine 3-carboxylate + NAD(P)+ = 3,4-dehydro-thiomorpholine-3-carboxylate + NAD(P)H + H+ [RN:
R04339 R04340 ]
Reaction(KEGG)
Substrate
Product
3,4-dehydro-thiomorpholine-3-carboxylate;
NADH [CPD:
C00004 ];
NADPH [CPD:
C00005 ];
H+ [CPD:
C00080 ]
Comment
The product is the cyclic imine of the 2-oxoacid corresponding to S-(2-aminoethyl)cysteine. In the reverse direction, a number of other cyclic unsaturated compounds can act as substrates, but more slowly.
History
EC 1.5.1.25 created 1990
Orthology
K18258 thiomorpholine-carboxylate dehydrogenase
Genes
DSP : 122116149(Crym) 122124921
MGP : 100541881 104913518(CRYM)
CJO : 107306902 107321007(CRYM)
SCAN : 103817679 115484293
PMUR : 107292093(CRYM) 107300571
PTEX : 113452661 113452668
XLA : 100101313(crym.L) 447114(crym.S)
SCLV : 120342475 120348143 120348144
SPU : 100890368 115926012 579068 593410
LPIC : 129274865 129274935
APLC : 110986982 110988835
SKO : 100376681 100377686 100378729
DSI : Dsimw501_GD17316(Dsim_GD17316)
SCAC : 106085711 106085713
BCOO : 119073013 119079613 119079830 119084539
PPYR : 116179010 116179070 116179241 116179244 116179251 116179252
HVI : 124353598 124353696 124373265
DPX : DAPPUDRAFT_16502 DAPPUDRAFT_187780
» show all
Taxonomy
Reference
Authors
Nardini M, Ricci G, Caccuri AM, Solinas SP, Vesci L, Cavallini D.
Title
Purification and characterization of a ketimine-reducing enzyme.
Journal
Other DBs
ExplorEnz - The Enzyme Database: 1.5.1.25
ExPASy - ENZYME nomenclature database: 1.5.1.25