KEGG ENZYME: 1.5.1.27

ENZYME: 1.5.1.27

Entry

EC 1.5.1.27                 Enzyme

Name

1,2-dehydroreticulinium reductase (NADPH);
1,2-dehydroreticulinium ion reductase

Class

Oxidoreductases;
Acting on the CH-NH group of donors;
With NAD+ or NADP+ as acceptor

Sysname

(R)-reticuline:NADP+ oxidoreductase

Reaction(IUBMB)

(R)-reticuline + NADP+ = 1,2-dehydroreticulinium + NADPH + H+ [RN:R04695]

Reaction(KEGG)

R04695

Substrate

(R)-reticuline [CPD:C05178];
NADP+ [CPD:C00006]

Product

1,2-dehydroreticulinium [CPD:C06167];
NADPH [CPD:C00005];
H+ [CPD:C00080]

Comment

Reduces the 1,2-dehydroreticulinium ion to (R)-reticuline, which is a direct precursor of morphinan alkaloids in the poppy plant. The enzyme does not catalyse the reverse reaction to any significant extent under physiological conditions.

History

EC 1.5.1.27 created 1999, modified 2004

Pathway

ec00950

Isoquinoline alkaloid biosynthesis

ec01100

Metabolic pathways

ec01110

Biosynthesis of secondary metabolites

Orthology

K22093

1,2-dehydroreticuline synthase/reductase

Genes

PSOM:

113322712

Reference

Authors

De-Eknamkul, W. and Zenk, M.H.

Title

Purification and properties of 1,2-dehydroreticulinium reductase from Papaver somniferum seedlings.

Journal

Phytochemistry 31:813-821 (1992)

Other DBs

ExplorEnz - The Enzyme Database:

1.5.1.27

IUBMB Enzyme Nomenclature:

1.5.1.27

ExPASy - ENZYME nomenclature database:

1.5.1.27

BRENDA, the Enzyme Database:

1.5.1.27

CAS:	130590-58-8

DBGET integrated database retrieval system