Entry Name FMN reductase (NADH);
Class Oxidoreductases;BRITE hierarchy
Sysname FMNH2:NAD+ oxidoreductase
Reaction(IUBMB) FMNH2 + NAD+ = FMN + NADH + H+ [RN:
R05705 ]
Reaction(KEGG) Substrate Product Comment The enzyme often forms a two-component system with monooxygenases. Unlike EC
1.5.1.38 , FMN reductase (NADPH), and EC
1.5.1.39 , FMN reductase [NAD(P)H], this enzyme has a strong preference for NADH over NADPH, although some activity with the latter is observed [1,2].
While FMN is the preferred substrate, FAD can also be used with much lower activity [1,3].
History EC 1.5.1.42 created 2011
Pathway Orthology K20146 nitrilotriacetate monooxygenase reductase component
Genes Taxonomy Reference Authors Duane W, Hastings JW.
Title Flavin mononucleotide reductase of luminous bacteria.
Journal Reference Authors Gerlo E, Charlier J
Title Identification of NADH-specific and NADPH-specific FMN reductases in Beneckea harveyi.
Journal Reference Authors Uetz T, Schneider R, Snozzi M, Egli T
Title Purification and characterization of a two-component monooxygenase that hydroxylates nitrilotriacetate from "Chelatobacter" strain ATCC 29600.
Journal Sequence Reference Authors Izumoto Y, Mori T, Yamamoto K
Title Cloning and nucleotide sequence of the gene for NADH:FMN oxidoreductase from Vibrio harveyi.
Journal Other DBs ExplorEnz - The Enzyme Database: 1.5.1.42
ExPASy - ENZYME nomenclature database: 1.5.1.42
