KEGG ENZYME: 1.5.1.45

ENZYME: 1.5.1.45

Entry

EC 1.5.1.45                 Enzyme

Name

FAD reductase [NAD(P)H];
GTNG_3158 (gene name)

Class

Oxidoreductases;
Acting on the CH-NH group of donors;
With NAD+ or NADP+ as acceptor

Sysname

FADH2:NAD(P)+ oxidoreductase

Reaction(IUBMB)

FADH2 + NAD(P)+ = FAD + NAD(P)H + H+ [RN:R09520 R09748]

Reaction(KEGG)

R09520 R09748

Substrate

FADH2 [CPD:C01352];
NAD+ [CPD:C00003];
NADP+ [CPD:C00006]

Product

FAD [CPD:C00016];
NADH [CPD:C00004];
NADPH [CPD:C00005];
H+ [CPD:C00080]

Comment

This enzyme, isolated from the bacterium Geobacillus thermodenitrificans, participates in the pathway of tryptophan degradation. The enzyme is part of a system that also includes a bifunctional riboflavin kinase/FMN adenylyltransferase and EC 1.14.14.8, anthranilate 3-monooxygenase (FAD). It can reduce either FAD or flavin mononucleotide (FMN) but prefers FAD. The enzyme has a slight preference for NADPH as acceptor. cf. EC 1.5.1.37, FAD reductase (NADH).

History

EC 1.5.1.45 created 2012

Pathway

ec00740

Riboflavin metabolism

ec01100

Metabolic pathways

Orthology

K16902

FAD reductase [NAD(P)H]

Genes

BMET:

BMMGA3_15280

GST:	HW35_13015

BACO:

OXB_0115

NTX:	NQZ71_16505

BMQ:

BMQ_3594

BMD:

BMD_3579

BMEG:

BG04_468

BKO:	CKF48_21905

CSOA:

LIS82_16125

BDA:	FSZ17_13420

OJD:	NP439_16250

OON:	NP440_15125

GTN:

GTNG_3158

GMC:	GY4MC1_3653

PTL:	AOT13_04015

ASED:

IRT44_17660

LYP:	MTP04_05370 MTP04_06180

HNZ:	P9989_01650 P9989_02080

HSAN:

MUN89_21615

HSHI:

MUO14_14530

HAMY:

MUO15_11750 MUO15_12285

VNT:	OLD84_18510

VIK:	KFZ58_18400

APAK:

AP3564_00250

BMUR:

ABE28_004135

PASA:

BAOM_0491

PFRI:

L8956_02840

RAX:	KO561_06640 KO561_15520

MLIT:

KDJ21_024660

BVJ:	I5776_05115

BOU:	I5818_06410

MSUT:

LC048_10450

DOM:	RRU94_06045 RRU94_18790

BHUI:

LOK74_00570 LOK74_23405

BAYD:

BSPP4475_07425

BBOR:

RFB14_22190

BRUM:

NDK47_11220

PBJ:	VN24_18680 VN24_25630

PNP:	IJ22_33750

PTHI:

NDS46_13530

PMAH:

PTQ21_20410

PDY:	QJQ58_08510

PSPN:

L1F29_06950

PPAB:

KET34_16295

PLIG:

NAG76_11950

EFF:	skT53_06260

SSIL:

SOLI23_13720

STHO:

QNH10_00625

UTH:	DKZ56_04195

ACTY:

OG774_22995

HSAI:

HPS36_14230

NARA:

QQ977_12260

» show all

Reference

1 [PMID:19942660]

Authors

Liu X, Dong Y, Li X, Ren Y, Li Y, Wang W, Wang L, Feng L

Title

Characterization of the anthranilate degradation pathway in Geobacillus thermodenitrificans NG80-2.

Journal

Microbiology 156:589-95 (2010)
DOI:10.1099/mic.0.031880-0

Sequence

[gtn:GTNG_3158]

Other DBs

ExplorEnz - The Enzyme Database:

1.5.1.45

IUBMB Enzyme Nomenclature:

1.5.1.45

ExPASy - ENZYME nomenclature database:

1.5.1.45

BRENDA, the Enzyme Database:

1.5.1.45

DBGET integrated database retrieval system