Entry
Name
4-methylaminobutanoate oxidase (methylamine-forming);
mao (gene name, ambiguous)
Class
Oxidoreductases;
Acting on the CH-NH group of donors;
With oxygen as acceptor
BRITE hierarchy
Sysname
4-methylaminobutanoate methylamidohydrolase
Reaction(IUBMB)
4-methylaminobutanoate + O2 + H2O = succinate semialdehyde + methylamine + H2O2 [RN:
R10101 ]
Reaction(KEGG)
Substrate
Product
Comment
The enzyme participates in the nicotine degradation pathway of the soil bacterium Arthrobacter nicotinovorans. Has a very weak monoamine oxidase (EC
1.4.3.4 ) activity with 4-aminobutanoate [1].
History
EC 1.5.3.21 created 2012
Pathway
ec00760 Nicotinate and nicotinamide metabolism
ec01120 Microbial metabolism in diverse environments
Orthology
K20155 4-methylaminobutanoate oxidase (methylamine-forming)
Genes
Taxonomy
Reference
Authors
Chiribau CB, Sandu C, Fraaije M, Schiltz E, Brandsch R
Title
A novel gamma-N-methylaminobutyrate demethylating oxidase involved in catabolism of the tobacco alkaloid nicotine by Arthrobacter nicotinovorans pAO1.
Journal
Sequence
Reference
Authors
Chiribau CB, Mihasan M, Ganas P, Igloi GL, Artenie V, Brandsch R
Title
Final steps in the catabolism of nicotine.
Journal
Sequence
Other DBs
ExplorEnz - The Enzyme Database: 1.5.3.21
ExPASy - ENZYME nomenclature database: 1.5.3.21
UM-BBD (Biocatalysis/Biodegradation Database): 1.5.3.21