KEGG   ENZYME: 1.5.3.22
Entry
EC 1.5.3.22                 Enzyme                                 
Name
coenzyme F420H2 oxidase;
FprA
Class
Oxidoreductases;
Acting on the CH-NH group of donors;
With oxygen as acceptor
Sysname
reduced coenzyme F420:oxygen oxidoreductase
Reaction(IUBMB)
2 reduced coenzyme F420 + O2 = 2 oxidized coenzyme F420 + 2 H2O [RN:R10602]
Reaction(KEGG)
R10602
Substrate
reduced coenzyme F420 [CPD:C01080];
O2 [CPD:C00007]
Product
oxidized coenzyme F420 [CPD:C00876];
H2O [CPD:C00001]
Comment
The enzyme contains FMN and a binuclear iron center. The enzyme from the archaeon Methanothermobacter marburgensis is Si-face specific with respect to C-5 of coenzyme F420 [2].
History
EC 1.5.3.22 created 2013
Orthology
K19817  coenzyme F420H2 oxidase
Genes
MJA: MJ_0748
MFE: Mefer_1066
MVU: Metvu_0447
MFS: MFS40622_1428
MIF: Metin_0358
MJH: JH146_1173
MESG: MLAUSG7_0421(fprA)
MESA: MLASG1_1600(fprA)
MIG: Metig_0112
MMP: MMP1134 MMP1135
MMQ: MmarC5_0450
MMZ: MmarC7_0386
MMD: GYY_06520 GYY_06525
MMAK: MMKA1_13130(fprA) MMKA1_13140(fprA)
MMAO: MMOS7_12430(fprA) MMOS7_12440(fprA)
MMAD: MMJJ_17110(fprA_2)
MAE: Maeo_0955
MVN: Mevan_0456 Mevan_0457
MVO: Mvol_0029 Mvol_0089
MOK: Metok_0623
METF: CFE53_02040
MTH: MTH_1350
MMG: MTBMA_c06690(fprA2) MTBMA_c17400(fprA3)
MWO: MWSIV6_0632(fprA) MWSIV6_1734(fpaA)
METC: MTCT_0182 MTCT_1224
METE: tca_00200(fprA_2) tca_01304(fprA_3)
METZ: METMT2_0665
METK: FVF72_01205 FVF72_04815
MTHM: FZP57_03005 FZP57_08485
METJ: FZP68_02240 FZP68_08040
METB: AW729_03335 AW729_05285
MEIS: PXD04_09260
MRU: mru_0131(fprA2) mru_1507(fprA1)
MSI: Msm_0222 Msm_1349
MEB: Abm4_0699(fprA1) Abm4_1680(fprA2)
MMIL: sm9_1011(fprA1) sm9_2237(fprA2)
MEYE: TL18_00440 TL18_05365
MOL: YLM1_0883 YLM1_1543
MARO: MarbSA_12840
METV: K4897_01570 K4897_04585
MEL: Metbo_0137 Metbo_0708
MEW: MSWAN_1545 MSWAN_2352
METH: MBMB1_1267(fprA) MBMB1_1978(fpaA)
MFC: BRM9_0483(fprA) BRM9_2322
MFI: DSM1535_0464(fprA1) DSM1535_1256(fprA3)
MCUB: MCBB_1482(fprA1) MCBB_2279(fprA3)
MSUB: BK009_05250 BK009_09185
METN: BK008_00795 BK008_04810
METT: CIT01_04960 CIT01_09555
METO: CIT02_07615 CIT02_11720
MEME: HYG87_05990
MFEG: GCM10025860_06480 GCM10025860_26120
MFV: Mfer_0426
MHU: Mhun_1554
MRTJ: KHC33_06000
MEM: Memar_0432
MBG: BN140_0391
MEMA: MMAB1_0501(fprA)
MCHK: MchiMG62_05600(fprA)
MPI: Mpet_0105
MOU: OU421_04815
MBN: Mboo_1153
MPL: Mpal_2265
MEZ: Mtc_2433(fprA-2)
 » show all
Reference
1  [PMID:15340796]
  Authors
Seedorf H, Dreisbach A, Hedderich R, Shima S, Thauer RK
  Title
F420H2 oxidase (FprA) from Methanobrevibacter arboriphilus, a coenzyme F420-dependent enzyme involved in O2 detoxification.
  Journal
Arch Microbiol 182:126-37 (2004)
DOI:10.1007/s00203-004-0675-3
  Sequence
[ag:ACA13278]
Reference
2  [PMID:16218963]
  Authors
Seedorf H, Kahnt J, Pierik AJ, Thauer RK
  Title
Si-face stereospecificity at C5 of coenzyme F420 for F420H2 oxidase from methanogenic Archaea as determined by mass spectrometry.
  Journal
FEBS J 272:5337-42 (2005)
DOI:10.1111/j.1742-4658.2005.04931.x
Reference
3  [PMID:17480207]
  Authors
Seedorf H, Hagemeier CH, Shima S, Thauer RK, Warkentin E, Ermler U
  Title
Structure of coenzyme F420H2 oxidase (FprA), a di-iron flavoprotein from methanogenic Archaea catalyzing the reduction of O2 to H2O.
  Journal
FEBS J 274:1588-99 (2007)
DOI:10.1111/j.1742-4658.2007.05706.x
Other DBs
ExplorEnz - The Enzyme Database: 1.5.3.22
IUBMB Enzyme Nomenclature: 1.5.3.22
ExPASy - ENZYME nomenclature database: 1.5.3.22
BRENDA, the Enzyme Database: 1.5.3.22

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Chemical substance (4)   
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   KEGG REACTION (1)   
   KEGG RCLASS (1)   
Gene (128)   
   KEGG ORTHOLOGY (1)   
   KEGG GENES (97)   
   KEGG MGENES (28)   
   RefGene (2)   
Protein sequence (9)   
   UniProt (5)   
   SWISS-PROT (4)   
Protein domain (8)   
   InterPro (8)   
All databases (151)   

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