KEGG   ENZYME: 1.5.7.1
Entry
EC 1.5.7.1                  Enzyme                                 
Name
methylenetetrahydrofolate reductase (ferredoxin);
5,10-methylenetetrahydrofolate reductase
Class
Oxidoreductases;
Acting on the CH-NH group of donors;
With an iron-sulfur protein as acceptor
Sysname
5-methyltetrahydrofolate:ferredoxin oxidoreductase
Reaction(IUBMB)
5-methyltetrahydrofolate + 2 oxidized ferredoxin = 5,10-methylenetetrahydrofolate + 2 reduced ferredoxin + 2 H+ [RN:R01217]
Reaction(KEGG)
R01217
Substrate
5-methyltetrahydrofolate [CPD:C00440];
oxidized ferredoxin [CPD:C00139]
Product
5,10-methylenetetrahydrofolate [CPD:C00143];
reduced ferredoxin [CPD:C00138];
H+ [CPD:C00080]
Comment
An iron-sulfur flavoprotein that also contains zinc. The enzyme from Clostridium formicoaceticum catalyses the reduction of methylene blue, menadione, benzyl viologen, rubredoxin or FAD with 5-methyltetrahydrofolate and the oxidation of reduced ferredoxin or FADH2 with 5,10-methylenetetrahydrofolate. However, unlike EC 1.5.1.53, methylenetetrahydrofolate reductase (NADPH); EC 1.5.1.54, methylenetetrahydrofolate reductase (NADH); or EC 1.5.1.20, methylenetetrahydrofolate reductase [NAD(P)H], there is no activity with either NADH or NADP+.
History
EC 1.5.7.1 created 2005, modified 2021
Pathway
ec00670  One carbon pool by folate
Reference
1  [PMID:6381490]
  Authors
Clark JE, Ljungdahl LG.
  Title
Purification and properties of 5,10-methylenetetrahydrofolate reductase, an iron-sulfur flavoprotein from Clostridium formicoaceticum.
  Journal
J Biol Chem 259:10845-9 (1984)
Other DBs
ExplorEnz - The Enzyme Database: 1.5.7.1
IUBMB Enzyme Nomenclature: 1.5.7.1
ExPASy - ENZYME nomenclature database: 1.5.7.1
BRENDA, the Enzyme Database: 1.5.7.1

  All links  
Pathway (2)   
   KEGG PATHWAY (2)   
Chemical substance (5)   
   KEGG COMPOUND (5)   
Chemical reaction (2)   
   KEGG REACTION (1)   
   KEGG RCLASS (1)   
Protein sequence (2)   
   UniProt (2)   
DNA sequence (8)   
   GenBank (4)   
   EMBL (4)   
All databases (19)   

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