KEGG ENZYME: 1.5.8.1

ENZYME: 1.5.8.1

Entry

EC 1.5.8.1                  Enzyme

Name

dimethylamine dehydrogenase

Class

Oxidoreductases;
Acting on the CH-NH group of donors;
With a flavin or flavoprotein as acceptor

Sysname

dimethylamine:electron-transfer flavoprotein oxidoreductase

Reaction(IUBMB)

dimethylamine + H2O + electron-transfer flavoprotein = methylamine + formaldehyde + reduced electron-transfer flavoprotein [RN:R01588]

Reaction(KEGG)

R01588

Substrate

dimethylamine [CPD:C00543];
H2O [CPD:C00001];
electron-transfer flavoprotein [CPD:C04253]

Product

methylamine [CPD:C00218];
formaldehyde [CPD:C00067];
reduced electron-transfer flavoprotein [CPD:C04570]

Comment

Contains FAD and a [4Fe-4S] cluster.

History

EC 1.5.8.1 created 1999 as EC 1.5.99.10, transferred 2002 to EC 1.5.8.1

Pathway

ec00680

Methane metabolism

ec01100

Metabolic pathways

ec01120

Microbial metabolism in diverse environments

Orthology

K00317

dimethylamine/trimethylamine dehydrogenase

Genes

PMEX:

H4W19_11290

RHD:	R2APBS1_0788

RTH:	LRK53_05475

DJI:	CH75_07125

DTX:	ATSB10_15590

XBA:	C7S18_14515

PRE:	PCA10_47330

PFC:	PflA506_4693(tmd)

POI:	BOP93_22725

PSHH:

HU773_024440

PHYG:

JTY93_23165

PTRL:

OU419_05970

HPIS:

P1P91_05060

TSN:	W908_00015

THIN:

CRN91_01375

RSO:

RSp0682

RSE:

F504_4539

RPU:	CDC45_21030

RNC:	GO999_17495

RSL:	RPSI07_mp0583

RSN:	RSPO_m01017(stcD)

RSM:	CMR15_mp10652

RSY:	RSUY_38890(tmd)

RSG:	JK151_04710

COX:	E0W60_31885

BPH:

Bphy_5960

BCAI:

K788_0001542

PHS:	C2L64_21885

PTER:

C2L65_26085

PSAA:

QEN71_34155

PPAI:

E1956_20380

PSPU:

NA29_08505

CDN:	BN940_13011

RHOA:

HZ993_23385

IDC:	LRM40_18490

CFU:

CFU_2684

CPRA:

CPter91_1920(tmd)

MEH:

M301_1400

MEI:	Msip34_2459

MEP:

MPQ_2403

AZA:	AZKH_p0217

AZI:	AzCIB_2375

MCI:	Mesci_2636

MCIC:

A4R28_14440

MOP:	Mesop_5984

MAM:	Mesau_02601

MESW:

A9K65_014455

MESP:

C1M53_02585

MERD:

EB233_12920 EB233_26910

MESR:

FGU64_14490

MMEI:

LRP31_28040

AAK:	AA2016_5993

PHT:	BLM14_27655

KMN:	HW532_16390

SME:

SMa0257

SMK:	Sinme_5357

SMX:	SM11_pC1602

SMI:	BN406_04939(tmd)

SMEG:

C770_GR4pC1294

SMEL:

SM2011_a0257

SMER:

DU99_24725

SMD:

Smed_1285

SIX:	BSY16_2386(hdh) BSY16_277

SKM:	PZL22_005785

ATA:	AWN88_01220

RHID:

FFM81_027465

SHZ:	shn_10745 shn_30205

SZO:	K8M09_09840 K8M09_20940

OIN:	IAR37_22770

OAN:

Oant_3262

OAH:	DR92_3227(hdh)

OPS:	A8A54_15775

BPSN:

NIK97_15890

OCH:	CES85_4558(tmd)

OCR:	HGK82_18870

OCL:	GTN27_18995

XAU:

Xaut_0917

STAR:

G3545_26390

LNE:	FZC33_09600 FZC33_21465

HDN:	Hden_0194 Hden_0535

HDT:	HYPDE_25228 HYPDE_25748 HYPDE_34963

HMC:	HYPMC_3962 HYPMC_3963

MCG:

GL4_2663

BLAG:

BLTE_16710

PLEO:

OHA_1_00468(tmd_1) OHA_1_00478(tmd_2)

NOH:	G5V57_02665 G5V57_05590 G5V57_06430 G5V57_31675

CAUL:

KCG34_05695 KCG34_22905

RUA:	D1823_18085

RCON:

K3740_03325

RDE:	RD1_4141(tmd)

RLI:	RLO149_c003340(tmd)

RPON:

G3256_12605 G3256_12610 G3256_12615

OAT:	OAN307_c42970(tmd)

OAR:	OA238_c47830(tmd1) OA238_c47840(tmd2) OA238_c47850(tmd3)

OTM:	OSB_15670(tmd)

LMD:	METH_21805

LEJ:	ETW24_01555 ETW24_05525

LCAE:

K3721_20240 K3721_20805

YAN:	AYJ57_15570

SUAM:

BOO69_07220

SULI:

C1J05_06740 C1J05_19580

SINL:

DSM14862_03441(tmd_1) DSM14862_03666(tmd_2)

RMM:	ROSMUCSMR3_03636(tmd)

ROK:	RAK1035_2462

RID:	RIdsm_00662(tmd_1) RIdsm_04243(tmd_2) RIdsm_04244(tmd_3)

ROM:	EI983_01485 EI983_01490 EI983_01495 EI983_09835 EI983_12585

ROH:	FIU89_18495(tmd)

RPEL:

N7U68_06485 N7U68_11895

AHT:	ANTHELSMS3_00564

THAA:

CFI11_03135

MALU:

KU6B_04850

RHP:	LPB142_07370

RBL:	B6K69_00080

PAMN:

pAMV3p0110(dmd) pAMV3p0194(tmd)

PSEW:

JHW44_16105

PSAP:

JHX88_10600

PFIS:

JHX87_13990

DON:	BSK21_05955

RBZ:	B9057_07560

GEH:	HYN69_03530 HYN69_12980

GFU:	KM031_01850 KM031_19465

TAW:	EI545_11145 EI545_19315

SEDI:

EBB79_22970 EBB79_23890

PPSO:

QPJ95_18105 QPJ95_18110 QPJ95_19445

HML:	HmaOT1_18870

PPRU:

FDP22_03105

PAED:

G5B38_12110 G5B38_17400 G5B38_20470

NSM:	JO391_00855 JO391_09270 JO391_14010

AALK:

LGT41_0005560

AMYL:

QBD29_02340 QBD29_12395

SNJ:	A7E77_04570

SMY:	BJP26_14925

SCH:	Sphch_1857

SMIC:

SmB9_20160

HTQ:	FRZ44_06770 FRZ44_10820 FRZ44_23470 FRZ44_47380

HADH:

FRZ61_06860 FRZ61_11050 FRZ61_23740

GSO:	PH603_02775

MDX:	BTO20_01230

MVQ:

MYVA_5919

MMAT:

MMAGJ_23260

MSEI:

MSEDJ_15750

MGO:	AFA91_30545

MRF:	MJO55_07995

MDF:	K0O62_08600

NYA:	LTV02_09175

RHA:	RHA1_ro01789

ROP:	ROP_14630 ROP_27330

ROA:	Pd630_LPD05948 Pd630_LPD07456

RKO:	JWS14_09075

RPSK:

JWS13_36935

GOI:	LK459_16700

GMG:	NWF22_14920

TPR:

Tpau_0381

SPHV:

F9278_41870

SANU:

K7396_16130

LDN:	H9L06_06465

NCA:	Noca_0579 Noca_0618

NARO:

CFH99_14995

PSIM:

KR76_16005

AGRA:

AGRA3207_001949

PHH:	AFB00_19150

KUT:	JJ691_53080(tmd)

PLK:	CIK06_05545

SBAE:

DSM104329_00584(tmd_1) DSM104329_02421(tmd_2) DSM104329_02427(tmd_3) DSM104329_03741(tmd_4)

RRS:	RoseRS_2964

RCA:

Rcas_1934

» show all

Reference

1 [PMID:7556160]

Authors

Yang CC, Packman LC, Scrutton NS

Title

The primary structure of Hyphomicrobium X dimethylamine dehydrogenase. Relationship to trimethylamine dehydrogenase and implications for substrate recognition.

Journal

Eur J Biochem 232:264-71 (1995)
DOI:10.1111/j.1432-1033.1995.tb20808.x

Sequence

[hdn:Hden_0194]

Other DBs

ExplorEnz - The Enzyme Database:

1.5.8.1

IUBMB Enzyme Nomenclature:

1.5.8.1

ExPASy - ENZYME nomenclature database:

1.5.8.1

UM-BBD (Biocatalysis/Biodegradation Database):

1.5.8.1

BRENDA, the Enzyme Database:

1.5.8.1

CAS:	68247-64-3

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