KEGG ENZYME: 1.5.8.4

ENZYME: 1.5.8.4

Entry

EC 1.5.8.4                  Enzyme

Name

dimethylglycine dehydrogenase;
N,N-dimethylglycine oxidase;
N,N-dimethylglycine:(acceptor) oxidoreductase (demethylating);
Me2GlyDH;
N,N-dimethylglycine:electron-transfer flavoprotein oxidoreductase (demethylating)

Class

Oxidoreductases;
Acting on the CH-NH group of donors;
With a flavin or flavoprotein as acceptor

Sysname

N,N-dimethylglycine,5,6,7,8-tetrahydrofolate:electron-transferflavoprotein oxidoreductase (demethylating,5,10-methylenetetrahydrofolate-forming)

Reaction(IUBMB)

N,N-dimethylglycine + 5,6,7,8-tetrahydrofolate + electron-transfer flavoprotein = sarcosine + 5,10-methylenetetrahydrofolate + reduced electron-transfer flavoprotein [RN:R01565]

Reaction(KEGG)

R01565

Substrate

N,N-dimethylglycine [CPD:C01026];
5,6,7,8-tetrahydrofolate [CPD:C00101];
electron-transfer flavoprotein [CPD:C04253]

Product

sarcosine [CPD:C00213];
5,10-methylenetetrahydrofolate [CPD:C00143];
reduced electron-transfer flavoprotein [CPD:C04570]

Comment

A flavoprotein, containing a histidyl(Npi)-(8alpha)FAD linkage at position 91 in the human protein. An imine intermediate is channeled from the FAD binding site to the 5,6,7,8-tetrahydrofolate binding site through a 40 A tunnel [5,8,9]. In the absence of 5,6,7,8-tetrahydrofolate the enzyme forms formaldehyde [5,9].

History

EC 1.5.8.4 created 1972 as EC 1.5.99.2, transferred 2012 to EC 1.5.8.4, modified 2017

Pathway

ec00260

Glycine, serine and threonine metabolism

ec01100

Metabolic pathways

Orthology

K00315

dimethylglycine dehydrogenase

Genes

HSA:	29958(DMGDH)

PTR:	471505(DMGDH)

PPS:	100985018(DMGDH)

GGO:	101138464(DMGDH)

PON:	100457567(DMGDH)

NLE:	100587925(DMGDH)

HMH:	116471071(DMGDH)

MCC:	709237(DMGDH)

MCF:	102117996(DMGDH)

MTHB:

126957578

MNI:	105475093(DMGDH)

CSAB:

103223602(DMGDH)

CATY:

105599277(DMGDH)

PANU:

101021742(DMGDH)

TGE:	112626239(DMGDH)

MLEU:

105548269(DMGDH)

RRO:	104662973(DMGDH)

RBB:	108528899(DMGDH)

TFN:	117065309(DMGDH)

PTEH:

111544504(DMGDH)

CANG:

105524185(DMGDH)

CJC:	100393734(DMGDH)

SBQ:	101045195(DMGDH)

CIMI:

108303776(DMGDH)

CSYR:

103271037(DMGDH)

MMUR:

105872621(DMGDH)

LCAT:

123648426(DMGDH)

PCOQ:

105826497(DMGDH)

OGA:	100945232(DMGDH)

MMU:	74129(Dmgdh)

MCAL:

110307602(Dmgdh)

MPAH:

110329016(Dmgdh)

RNO:	245961(Dmgdh)

MCOC:

116083192(Dmgdh)

ANU:	117700509(Dmgdh)

MUN:	110539648(Dmgdh)

CGE:	100759503(Dmgdh)

MAUA:

101825798(Dmgdh)

PROB:

127221075(Dmgdh)

PLEU:

114694633(Dmgdh)

MORG:

121455768(Dmgdh)

MFOT:

126508483

AAMP:

119810202(Dmgdh)

NGI:	103750305(Dmgdh)

HGL:	101722315(Dmgdh)

CPOC:

100724353(Dmgdh)

CCAN:

109675254(Dmgdh)

DORD:

105985323(Dmgdh)

DSP:	122117211(Dmgdh)

PLOP:

125339841(Dmgdh)

NCAR:

124986616

MMMA:

107152308(Dmgdh)

OCU:

100340207

OPI:	101524954(DMGDH)

TUP:	102489576(DMGDH)

GVR:	103597319(DMGDH)

CFA:	488935(DMGDH)

CLUD:

112653283(DMGDH)

VVP:	112919589(DMGDH)

VLG:	121489124(DMGDH)

NPO:	129521083(DMGDH)

AML:	100466333(DMGDH)

UMR:	103681493(DMGDH)

UAH:	113254981(DMGDH)

UAR:	123791537(DMGDH)

ELK:

111148380

LLV:

125100500

MPUF:

101682529(DMGDH)

MNP:	132028757(DMGDH)

MLK:	131832392(DMGDH)

NVS:	122918260(DMGDH)

ORO:	101373953(DMGDH)

EJU:	114217588(DMGDH)

ZCA:	113929748(DMGDH)

MLX:	118016932(DMGDH)

NSU:	110587431(DMGDH)

LWW:	102732159(DMGDH)

FCA:	101089168(DMGDH)

PYU:	121014025(DMGDH)

PCOO:

112860572(DMGDH)

PBG:	122490193(DMGDH)

PVIV:

125172158(DMGDH)

LRUF:

124504400

PTG:	102963363(DMGDH)

PPAD:

109274942(DMGDH)

PUC:

125934944

AJU:

106974795

HHV:	120242009(DMGDH)

BTA:	504453(DMGDH)

BOM:	102287393(DMGDH)

BIU:	109564663(DMGDH)

BBUB:

102393250(DMGDH)

BBIS:

104984715(DMGDH)

CHX:	102189681(DMGDH)

OAS:	101113594(DMGDH)

BTAX:

128054427(DMGDH)

ODA:	120852578(DMGDH)

CCAD:

122443005(DMGDH)

MBEZ:

129563602(DMGDH)

SSC:	100525563(DMGDH)

CFR:	102522919(DMGDH)

CBAI:

105064350(DMGDH)

CDK:	105084826(DMGDH)

VPC:	102525581(DMGDH)

BACU:

103000721(DMGDH)

BMUS:

118892301(DMGDH)

LVE:	103081304(DMGDH)

OOR:	101281736(DMGDH)

DLE:	111184963(DMGDH)

PCAD:

102991899(DMGDH)

PSIU:

116752240(DMGDH)

NASI:

112406749(DMGDH)

ECB:	100073267(DMGDH)

EPZ:	103548668(DMGDH)

EAI:	106841177(DMGDH)

MYB:	102246690(DMGDH)

MYD:	102758327(DMGDH)

MMYO:

118656692(DMGDH)

MLF:	102426434(DMGDH)

PKL:	118703203(DMGDH)

EFUS:

103305220(DMGDH)

MNA:	107535045(DMGDH)

DRO:	112307504(DMGDH)

SHON:

118977291(DMGDH)

AJM:	119048139(DMGDH)

PDIC:

114508094(DMGDH)

PHAS:

123824645(DMGDH)

MMF:	118641668(DMGDH)

PPAM:

129074637(DMGDH)

HAI:	109381891(DMGDH)

RFQ:	117024941(DMGDH)

PALE:

102895924(DMGDH)

PGIG:

120612467(DMGDH)

PVP:	105303565(DMGDH)

RAY:	107497232(DMGDH)

MJV:	108398417(DMGDH)

TOD:	119260223(DMGDH)

SARA:

101540926(DMGDH)

LAV:	100671550(DMGDH)

TMU:

101355257

ETF:	101642554(DMGDH)

DNM:	101441072(DMGDH)

MDO:	100032620(DMGDH)

GAS:	123251619(DMGDH)

SHR:	100931635(DMGDH)

AFZ:

127558452

PCW:	110216593(DMGDH)

OAA:	100088110(DMGDH)

GGA:	416370(DMGDH)

PCOC:

116239924(DMGDH)

CJO:	107305932(DMGDH)

TPAI:

128074388(DMGDH)

LMUT:

125687325(DMGDH)

NMEL:

110389379(DMGDH)

APLA:

101802594(DMGDH)

ACYG:

106042090(DMGDH)

CATA:

118251485(DMGDH)

AFUL:

116500625

TGU:	100231246(DMGDH)

LSR:	110470993(DMGDH)

SCAN:

103819544(DMGDH)

PMOA:

120502443(DMGDH)

OTC:	121341266(DMGDH)

PRUF:

121355471(DMGDH)

GFR:	102044591(DMGDH)

FAB:	101806587(DMGDH)

OMA:	130265577(DMGDH)

PHI:	102112577(DMGDH)

PMAJ:

107216431(DMGDH)

CCAE:

111941402(DMGDH)

CCW:	104695710(DMGDH)

CBRC:

103622044(DMGDH)

ETL:	114056907(DMGDH)

ZAB:	102071490(DMGDH)

ACHL:

103804225(DMGDH)

SVG:	106856207(DMGDH)

MMEA:

130572274(DMGDH)

HRT:	120765161(DMGDH)

FPG:	101910969(DMGDH)

FCH:	102049188(DMGDH)

CLV:	102091750(DMGDH)

EGZ:	104124898(DMGDH)

NNI:	104017622(DMGDH)

PLET:

104622259(DMGDH)

EHS:	104516007(DMGDH)

PCAO:

104053649(DMGDH)

ACUN:

113489761(DMGDH)

TALA:

104369114(DMGDH)

PADL:

103919764(DMGDH)

AFOR:

103899794(DMGDH)

ACHC:

115336615(DMGDH)

HALD:

104313141(DMGDH)

HLE:	104841314(DMGDH)

AGEN:

126035661

GCL:

127027345

CCRI:

104161024(DMGDH)

CSTI:

104549619(DMGDH)

CMAC:

104482089(DMGDH)

MUI:	104547929(DMGDH)

BREG:

104629029(DMGDH)

FGA:	104076537(DMGDH)

GSTE:

104256601(DMGDH)

LDI:	104342607(DMGDH)

MNB:	103779014(DMGDH)

OHA:	104331094(DMGDH)

NNT:	104411635(DMGDH)

SHAB:

115601219(DMGDH)

DPUB:

104309468(DMGDH)

ACAR:

104529321(DMGDH)

CPEA:

104395694(DMGDH)

AVIT:

104268283(DMGDH)

CVF:	104285792(DMGDH)

RTD:	128902454(DMGDH)

CUCA:

104064015(DMGDH)

TEO:	104382592(DMGDH)

BRHI:

104493397(DMGDH)

AROW:

112967364(DMGDH)

NPD:	112945129(DMGDH)

TGT:	104581209(DMGDH)

DNE:	112987054(DMGDH)

SCAM:

104152992(DMGDH)

ASN:	102383441(DMGDH)

AMJ:	102561678(DMGDH)

CPOO:

109307687(DMGDH)

GGN:	109297739(DMGDH)

PSS:	102445412(DMGDH)

CMY:	102947394(DMGDH)

CCAY:

125636504(DMGDH)

DCC:	119855821(DMGDH)

CPIC:

101938519(DMGDH)

TST:	117878733(DMGDH)

CABI:

116821376(DMGDH) 116823757

MRV:	120408207(DMGDH)

ACS:	100564503(dmgdh)

ASAO:

132767047(DMGDH)

PVT:	110073960(DMGDH)

SUND:

121921272(DMGDH)

PBI:	103049444(DMGDH)

PMUR:

107287877(DMGDH)

CTIG:

120312301(DMGDH)

TSR:	106544490(DMGDH)

PGUT:

117679271(DMGDH)

APRI:

131192925(DMGDH)

PTEX:

113447487(DMGDH)

NSS:	113413945(DMGDH)

VKO:	123031610(DMGDH)

PMUA:

114606167(DMGDH)

PRAF:

128423191(DMGDH)

ZVI:	118076697(DMGDH)

HCG:	128344706(DMGDH)

GJA:	107117472(DMGDH)

STOW:

125436278(DMGDH)

EMC:	129334811(DMGDH)

XLA:	446949(dmgdh.L)

XTR:	100492188(dmgdh)

NPR:	108799972(DMGDH)

RTEM:

120929326(DMGDH)

BBUF:

120992414(DMGDH)

BGAR:

122924737(DMGDH)

MUO:	115463049(DMGDH)

GSH:	117353532(DMGDH)

DRE:	100141496(dmgdh)

SRX:	107717757 107724713

SANH:

107694541(dmgdh)

SGH:	107574100(dmgdh)

CAUA:

113080753 113090445

CGIB:

127942093

PTET:

122341030(dmgdh)

LROH:

127162117(dmgdh)

OMC:	131528434(dmgdh)

PPRM:

120461889(dmgdh)

RKG:	130088054(dmgdh)

MAMB:

125252260(dmgdh)

CIDE:

127504041

MASI:

127428970 127430822

TROS:

130550719 130550721

TDW:	130407732(dmgdh)

MANU:

129423062(dmgdh)

IPU:

108279027

IFU:	128622543(dmgdh)

PHYP:

113535384(dmgdh)

SMEO:

124398447(dmgdh)

TFD:	113646386(dmgdh)

TVC:	132859925(dmgdh)

AMEX:

103034486(dmgdh)

CMAO:

118819648(dmgdh)

EEE:	113573718(dmgdh)

TRU:	101062880(dmgdh)

TFS:	130517445(dmgdh)

LCO:	104936285(dmgdh)

NCC:	104966861(dmgdh)

TBEN:

117476531(dmgdh)

CGOB:

115016354(dmgdh)

PGEO:

117455765(dmgdh)

GACU:

117561382(dmgdh)

EMAC:

134868904(dmgdh)

ELY:	117269427(dmgdh)

EFO:	125905686(dmgdh)

PLEP:

121960316(dmgdh)

SLUC:

116062809(dmgdh)

ECRA:

117959334(dmgdh)

ESP:	116704779(dmgdh)

PFLV:

114570945(dmgdh)

GAT:	120832186(dmgdh)

PPUG:

119226901(dmgdh)

AFB:	129102455(dmgdh)

CLUM:

117740637(dmgdh)

PSWI:

130205405(dmgdh)

MSAM:

119914232(dmgdh)

SCHU:

122865355(dmgdh)

CUD:	121525709(dmgdh)

ALAT:

119030451(dmgdh)

MZE:	101476130(dmgdh)

ONL:	100707764(dmgdh)

OAU:	116315576(dmgdh)

OLA:	101169624(dmgdh)

OML:	112162824(dmgdh)

CSAI:

133455077(dmgdh)

XMA:	102227264(dmgdh)

XCO:	114150099(dmgdh)

XHE:	116724977(dmgdh)

PRET:

103473305(dmgdh)

PFOR:

103135836(dmgdh)

PLAI:

106937103(dmgdh)

PMEI:

106916209(dmgdh)

GAF:	122819376(dmgdh)

PPRL:

129374177(dmgdh)

CVG:	107093770(dmgdh)

CTUL:

119788279(dmgdh)

GMU:	124872054(dmgdh)

NFU:	107374847(dmgdh)

KMR:	108251297(dmgdh)

ALIM:

106515070(dmgdh)

NWH:	119424604(dmgdh)

AOCE:

111570345(dmgdh)

MCEP:

124997064(dmgdh)

CSEM:

103390008(dmgdh)

POV:	109626536(dmgdh)

SSEN:

122758600(dmgdh)

HHIP:

117771689(dmgdh)

HSP:	118098095(dmgdh)

SMAU:

118301041(dmgdh)

LCF:

108895442

SDU:	111239025(dmgdh)

SLAL:

111666799(dmgdh)

XGL:	120806343(dmgdh)

HCQ:	109517687(dmgdh)

SSCV:

125979272

SBIA:

133515232(dmgdh)

PEE:	133413930(dmgdh)

PTAO:

133489841(dmgdh)

BPEC:

110157318(dmgdh)

MALB:

109953004(dmgdh)

BSPL:

114867452(dmgdh)

SJO:	128380734(dmgdh)

SASA:

106568126(dmgdh)

STRU:

115159734

OTW:	112220276(dmgdh)

OMY:	110523447(dmgdh)

OGO:	124049092(dmgdh)

ONE:	115121049(dmgdh)

OKI:

109867929

OKE:	118371635(dmgdh)

SALP:

111961762

SNH:

120025444

CCLU:

121541556 121582648(dmgdh)

ELS:	105015173(dmgdh)

SFM:	108925069(dmgdh)

PKI:	111849812(dmgdh)

AANG:

118213302(dmgdh)

LOC:	102682151(dmgdh)

PSPA:

121305151(dmgdh)

ARUT:

117403612 117404061

PSEX:

120532415(dmgdh)

LCM:

102353346

CMK:	103177764(dmgdh)

CPLA:

122558379(dmgdh)

HOC:	132822379(dmgdh)

LERI:

129694842(dmgdh)

PMRN:

116942188(DMGDH)

LRJ:	133343912 133343915

BFO:	118409370 118409371 118409372

BBEL:

109475888 109476278

SPU:

587447

LPIC:

129262596

APLC:

110987881 110988117 110988587

AJC:

117119805

SKO:	100377832 100377978

IEL:

124153972

PVM:

113817447

PJA:

122247004

PCHN:

125035399

PMOO:

119583530

HAME:

121878893

PCLA:

123771694

CQD:	128696648 128696657

PTRU:

123512442

ESN:

127008694

HAZT:

108669472

EAF:

111708869

PPOI:

119096221 119096222

DSV:

119442633

RSAN:

119387354 119387359

RMP:

119188313

PTEP:

107451370

ABRU:

129961803

UDV:

129225265

SDM:

118188531

LPOL:

106462892

CEL:	CELE_Y37E3.17(Y37E3.17)

CBR:

CBG_22093

CRQ:	GCK72_001081

NAI:	NECAME_09711

BMY:	BM_BM6398(Bm6398)

LOA:	LOAG_05663

LAK:

106166448

NVE:

5512014

EPA:

110231395

ATEN:

116305412

ADF:

107342978

AMIL:

114953801

PDAM:

113682317 113683486

SPIS:

111324311 111327844

DGT:

114533878

HMG:

100209590

HSY:

130644981

TAD:	TRIADDRAFT_54121

SMIN:

v1.2.028204.t1(symbB.v1.2.028204.t1) v1.2.028204.t2(symbB.v1.2.028204.t2) v1.2.028204.t3(symbB.v1.2.028204.t3)

SPAR:

SPRG_07877

EHX:	EMIHUDRAFT_457242

PKK:	QQ992_12820

GAI:	IMCC3135_12455(abo_3) IMCC3135_18055(abo_4) IMCC3135_27130(abo_5)

HAF:	C8233_04785

MRZ:	KDW95_13055 KDW95_18085

TSN:	W908_00470 W908_00955 W908_05595 W908_07550

THIN:

CRN91_00510 CRN91_00900 CRN91_02465 CRN91_02630

BGO:

BM43_4044

PKF:	RW095_14000

TVL:	FAZ95_10840

AZA:	AZKH_p0176

MLO:	mll1517 mll1653 mll2449 mlr1213 mlr1280

MLN:	A9174_01365 A9174_12360 A9174_18060 A9174_18565 A9174_20015 A9174_20275 A9174_30160

MCI:	Mesci_0276 Mesci_3080 Mesci_3179 Mesci_3332 Mesci_3392 Mesci_3401 Mesci_5747

MCIC:

A4R28_09725 A4R28_09770 A4R28_10085 A4R28_10870 A4R28_12265 A4R28_26990

MOP:	Mesop_3464 Mesop_3570 Mesop_3782 Mesop_3823 Mesop_3876 Mesop_6323

MAM:	Mesau_03350 Mesau_03612 Mesau_03663 Mesau_05797

MAMO:

A6B35_09220 A6B35_10505 A6B35_12565 A6B35_21685 A6B35_21955 A6B35_23330

MESW:

A9K65_001380 A9K65_016715 A9K65_017220 A9K65_018025 A9K65_018325 A9K65_018375

MESM:

EJ066_25580 EJ066_25820 EJ066_27085

MESP:

C1M53_21985 C1M53_24225 C1M53_24480

MHUA:

MCHK_0600 MCHK_2856 MCHK_2910 MCHK_3149 MCHK_3256 MCHK_4075 MCHK_6281

MJR:	EB229_01390 EB229_12225 EB229_18325 EB229_18850 EB229_19775 EB229_20045 EB229_30760

MERD:

EB233_01470 EB233_12470 EB233_15650 EB233_16180 EB233_17110 EB233_17420 EB233_26985

MESR:

FGU64_05200 FGU64_05430

MOH:	IHQ72_13450 IHQ72_16530 IHQ72_17795 IHQ72_18020

MMEI:

LRP31_16770 LRP31_18015 LRP31_18255 LRP31_33515

MESO:

BSQ44_15470 BSQ44_15795

CHEA:

PVE73_11055

HOE:	IMCC20628_00539 IMCC20628_01684

AAK:	AA2016_2973 AA2016_3040

AMIH:

CO731_02954(gcvT_6) CO731_03008(gcvT_9) CO731_03534(gcvT_11)

AMIS:

Amn_33920 Amn_34580

ANJ:	AMD1_2874(gcvT) AMD1_2933(gcvT) AMD1_3493(gcvT)

PHT:	BLM14_05370 BLM14_05485 BLM14_08065

PHYL:

HB779_17815 HB779_17945

RPOD:

E0E05_04465

NIY:	FQ775_22505

NKI:	KW403_01365 KW403_16460

NRH:	T8J41_13240 T8J41_16880

ORM:	HTY61_02185

KMN:	HW532_09130 HW532_10840

SME:	SMa1483 SMc01663

SMK:	Sinme_2255 Sinme_6001

SMQ:	SinmeB_2099 SinmeB_6321

SMX:	SM11_chr0983 SM11_pC0842

SMI:	BN406_02099 BN406_04544

SMEG:

C770_GR4Chr2334 C770_GR4pC0569

SMEL:

SM2011_a1483 SM2011_c01663

SMER:

DU99_12730 DU99_21970

SMD:	Smed_2198 Smed_5112

RHI:	NGR_b16530 NGR_c21820

SFH:	SFHH103_02078

SFD:	USDA257_c45740(gcvT5)

SIX:	BSY16_102 BSY16_4802 BSY16_522

SAME:

SAMCFNEI73_Ch2544

SINO:

SS05631_c23310

ESJ:	SJ05684_c23260

EAK:	EKH55_2257

EMX:	FKV68_14760

ENU:	PYH37_004747

EGI:	PZN02_002416

SKM:	PZL22_002610 PZL22_005008

STEG:

QA637_11400

EAD:	OV14_3709 OV14_4043 OV14_a0111

EAH:	FA04_11570 FA04_13205

ECAA:

J3R84_11705 J3R84_13580 J3R84_27260

ENP:	JVX98_08120 JVX98_26555

ATU:

Atu1632

ATA:	AWN88_13155

AGR:	AGROH133_06455

ATF:	Ach5_15600

AGC:	BSY240_4127

AGT:	EYD00_06215

ALF:	CFBP5473_07370

ARUI:

G6M88_01705

AVQ:	HRR99_08460

AVV:	RvVAT039_01930

AVF:	RvVAR031_23200

ASAL:

CFBP5507_06825

RIR:	BN877_I1595

RPUS:

CFBP5875_06765

ACUC:

KZ699_06580

ALEG:

CFBP4996_06510

AVI:

Avi_2727

RLT:	Rleg2_3310

RTR:	RTCIAT899_CH13890

RHL:	LPU83_2074

RHV:	BA939_02800

RJG:	CCGE525_12245 CCGE525_15975

RHR:	CKA34_16800

RAD:	CO657_17030

ROY:	G3A56_02985

RROS:

D4A92_00005

RRHO:

PR018_10905 PR018_18620

RTU:	PR017_11065 PR017_27300

ARA:	Arad_3491 Arad_7067

ARO:	B0909_04860

NGL:	RG1141_CH19670

NGG:	RG540_CH20470

NEO:	CYG48_06565

NEN:	NCHU2750_25890 NCHU2750_44930

NPM:	QEO92_10585

RHT:

NT26_1995

RFV:	RFYW14_02071

SHZ:	shn_12225 shn_14410

SZO:	K8M09_10925

SOJ:	K6301_09700 K6301_11200 K6301_20490

SSUM:

Q9314_15460 Q9314_16950 Q9314_19625

ABAW:

D5400_09000

PDES:

FE840_016960

OIN:	IAR37_13385

OCH:	CES85_4737

PSCQ:

KHQ08_09115 KHQ08_11380

BVES:

QO058_28675

LNE:	FZC33_05130 FZC33_07605 FZC33_17220 FZC33_19170

MMYR:

MXMO3_00053

MEY:	TM49_20070

MAAD:

AZF01_13610

MMED:

Mame_04001(gcvT_3)

MLUT:

JET14_14775

AUZ:	Sa4125_28800

AUB:	LXB15_10385

JAV:	OXU80_10315

NOH:	G5V57_01050 G5V57_25045 G5V57_32635

RBM:	TEF_07375 TEF_16760

PSF:

PSE_p0029

LAP:	ACP90_05180

LABR:

CHH27_14530 CHH27_15475 CHH27_24580

LABP:

FJ695_07950 FJ695_09645 FJ695_25365

LABT:

FIU93_10825(mlr1)

LAGG:

B0E33_16735

SIW:	GH266_01350

LIZ:	LGH83_00890 LGH83_07170

CAUL:

KCG34_01975

SIL:	SPO0207 SPO0544 SPO0564 SPO0635 SPO1592 SPO1628 SPO3400 SPOA0063 SPOA0310

SIT:	TM1040_0486 TM1040_1426 TM1040_2063

RUA:	D1823_00950 D1823_02745 D1823_06845 D1823_08205 D1823_10250 D1823_12790 D1823_16990 D1823_20780

RUT:	FIU92_00690(mlr1) FIU92_03040(mlr3) FIU92_05050(mlr4) FIU92_06380(mlr5) FIU92_10495(mlr6) FIU92_12160(mlr7) FIU92_14470(mlr9) FIU92_18060(mlr10) FIU92_20150(mlr14)

RCON:

K3740_07250 K3740_12625 K3740_13670 K3740_14665 K3740_15760 K3740_16870 K3740_22425 K3740_22620

JAN:	Jann_0919 Jann_1481 Jann_1596 Jann_2488 Jann_2805

RDE:	RD1_0019 RD1_0607 RD1_1345 RD1_3093 RD1_3434

RLI:	RLO149_c023240(dmgdh1) RLO149_c027920(dmgdh2) RLO149_c034400(dmgdh3) RLO149_c039110(dmgdh4) RLO149_p940550(dmgdh)

RPON:

G3256_01370 G3256_09520 G3256_09530 G3256_10965 G3256_14570 G3256_16305

DSH:	Dshi_1485 Dshi_2967

PGA:	PGA1_262p01400(dmgdH) PGA1_c14040(dmgdH1) PGA1_c25540(dmgdH2) PGA1_c28230(dmgdH3) PGA1_c33130(dmgdH4)

PGL:	PGA2_239p1580(dmgdH) PGA2_c13940(dmgdH1) PGA2_c26230(dmgdH2) PGA2_c31400(dmgdH3)

PGD:	Gal_00601 Gal_01999 Gal_03372 Gal_03876

PHP:	PhaeoP97_00680(dmgdH3) PhaeoP97_01401(dmgdH1) PhaeoP97_03223(dmgdH4) PhaeoP97_03709(dmgdH)

PPIC:

PhaeoP14_01307(dmgdH1) PhaeoP14_02584(dmgdH3) PhaeoP14_03111(dmgdH4) PhaeoP14_03603(dmgdH)

PHQ:	D1820_03020 D1820_08825 D1820_11350 D1820_17765

OAT:	OAN307_c07010(dmgdh5) OAN307_c24050(dmgdh3) OAN307_c24060(dmgdh1) OAN307_c42890(dmgdh2) OAN307_c46320(dmgdh4)

OAR:	OA238_c04890(dmgdh2) OA238_c19930(dmgdh1) OA238_c19940(dmgdh3) OA238_c34950(dmgdh5) OA238_c40910(dmgdh4)

OTM:	OSB_05340(mlr_1) OSB_15100(mlr_2) OSB_15120(mlr_3) OSB_26970(mlr_5) OSB_30270(mlr_7)

OCT:	FTO60_03970 FTO60_07420 FTO60_07425 FTO60_12415 FTO60_13430 FTO60_15110

LMD:	METH_03735 METH_03940 METH_10325 METH_15465 METH_18800 METH_19120 METH_21940 METH_22240

LEJ:	ETW24_01830 ETW24_04590 ETW24_05260 ETW24_11035 ETW24_15600 ETW24_18640 ETW24_20765 ETW24_21005

LAQU:

R2C4_02365 R2C4_03560 R2C4_07700 R2C4_13145 R2C4_19080

LEV:	ETW23_01350 ETW23_14330 ETW23_14920 ETW23_15480 ETW23_21115 ETW23_22940

LCAE:

K3721_03875 K3721_03965 K3721_09475 K3721_13810 K3721_15285 K3721_16875 K3721_19865 K3721_20370

RED:	roselon_00386 roselon_02666 roselon_03053

MALG:

MALG_00176 MALG_02067 MALG_02872 MALG_05031

CON:	TQ29_02695 TQ29_08680

YAN:	AYJ57_04365

SUAM:

BOO69_09345 BOO69_09355 BOO69_14040 BOO69_14970 BOO69_16555

SULZ:

C1J03_02070 C1J03_02180 C1J03_12000 C1J03_12980 C1J03_12985 C1J03_18530 C1J03_24870

SULI:

C1J05_00620 C1J05_01555 C1J05_03595 C1J05_03615 C1J05_06305 C1J05_09340 C1J05_09350 C1J05_17060 C1J05_17365

SULD:

B5M07_03755 B5M07_09395 B5M07_10375

SPOT:

G6548_05775

SMED:

JNX03_03690 JNX03_03695 JNX03_10375 JNX03_12625 JNX03_14895 JNX03_17695

SINL:

DSM14862_01486(abo_1) DSM14862_01603(abo_3) DSM14862_02797(abo_4)

SFAV:

PL335_07650 PL335_13005

SUAL:

KDD17_01820 KDD17_04860 KDD17_16700 KDD17_17090

SDUB:

R1T39_13740

SPSE:

SULPSESMR1_00305(abo) SULPSESMR1_01729(abo) SULPSESMR1_01730(abo) SULPSESMR1_02942(abo)

TOM:	BWR18_06035 BWR18_06045 BWR18_12820 BWR18_14145 BWR18_15290 BWR18_17915

RMM:	ROSMUCSMR3_00197(abo) ROSMUCSMR3_00199(abo) ROSMUCSMR3_01611(dmg) ROSMUCSMR3_02526(abo) ROSMUCSMR3_03060(abo)

ROK:	RAK1035_0653 RAK1035_1554 RAK1035_1955 RAK1035_3049 RAK1035_3051

RID:	RIdsm_01012(gcvT_2) RIdsm_01919(gcvT_6) RIdsm_02570(gcvT_9) RIdsm_02572(gcvT_10) RIdsm_02862(gcvT_11) RIdsm_04377(gcvT_13) RIdsm_04955(gcvT_17) RIdsm_05137(gcvT_18) RIdsm_05412(gcvT_19)

ROM:	EI983_07495 EI983_07510 EI983_08870 EI983_10870 EI983_11245 EI983_15160 EI983_16220 EI983_18010

ROH:	FIU89_01700(mlr1) FIU89_04725(mlr3) FIU89_05485(mlr5) FIU89_09085(mlr6) FIU89_09090(mlr7)

RPEL:

N7U68_01680 N7U68_01695 N7U68_03735 N7U68_04390 N7U68_11165 N7U68_15355 N7U68_15850

AHT:	ANTHELSMS3_00322 ANTHELSMS3_02047 ANTHELSMS3_02167 ANTHELSMS3_03636 ANTHELSMS3_03637 ANTHELSMS3_04119(gcvT)

SAGU:

CDO87_04200 CDO87_04815 CDO87_18660

THAA:

CFI11_10575 CFI11_10585 CFI11_17605 CFI11_17875 CFI11_21505

OCD:	FHY55_05645 FHY55_10830

ROT:	FIV09_01580(mlr1)

RMH:	LVO79_13600

MALU:

KU6B_16150 KU6B_29170 KU6B_29180 KU6B_41430 KU6B_42750 KU6B_44080

TGL:	HFZ77_01210

HAT:	RC74_01400

LSAL:

KBK07_01945

LALG:

LentiSH36_00144(dmgdH3) LentiSH36_00395(dmgdH1_1) LentiSH36_01371(dmgdH) LentiSH36_01372(dmgdH1_2) LentiSH36_02504(dmgdH2) LentiSH36_02924(dmgdH4)

TRY:	QF118_09455 QF118_10250 QF118_12630 QF118_12635 QF118_18490

MARU:

FIU81_03420(mlr)

RMAI:

MACH21_09120 MACH21_13320 MACH21_24120

RSP:

RSP_3566

RSH:	Rsph17029_3249

RSQ:	Rsph17025_3155

RSK:	RSKD131_3734

CAZT:

LV780_15740

RCP:	RCAP_rcc00526

RHP:	LPB142_03920

RBL:	B6K69_00135 B6K69_00670 B6K69_07415

PDE:

Pden_1940

PAMI:

JCM7686_0185

PYE:	A6J80_15065

PZH:	CX676_08395 CX676_11705

PARO:

CUV01_18175

PARS:

DRW48_15525

PARR:

EOJ32_13270

PAAK:

FIU66_08115 FIU66_16345

PKD:	F8A10_07450

PPAN:

ESD82_13955

PLIA:

E4191_12060

PMAU:

CP157_00951(abo)

PMEH:

JWJ88_03720

PSEW:

JHW44_16570 JHW44_16690

PSAP:

JHX88_09195 JHX88_14910

PFIS:

JHX87_06120

PSTL:

JHW45_04070

PTP:	RCA23_c00660 RCA23_c01560 RCA23_c15530 RCA23_c15540 RCA23_c20240 RCA23_c21230

RSU:

NHU_00780

RHM:	B5V46_04750

RMB:	K529_002195 K529_003550 K529_006445

TSCO:

R1T40_01480 R1T40_01935 R1T40_04815 R1T40_15290

DAA:	AKL17_0631 AKL17_1896

DON:	BSK21_11185

RBZ:	B9057_02430

THW:	BMG03_16345

TEC:	AKL02_016090

LVS:	LOKVESSMR4R_00303(abo) LOKVESSMR4R_02748(abo)

RBG:	BG454_17160 BG454_17495 BG454_17960

GEH:	HYN69_00790 HYN69_09150

GFU:	KM031_00015 KM031_00510 KM031_13160

TAW:	EI545_00905 EI545_01500 EI545_13050

SALO:

EF888_02530

SEDI:

EBB79_09265 EBB79_11090 EBB79_17395 EBB79_23745

PPSO:

QPJ95_05440 QPJ95_19025 QPJ95_22325

HML:	HmaOT1_07020

BOO:	E2K80_03410 E2K80_06725 E2K80_08300 E2K80_09280 E2K80_14235

PSEB:

EOK75_17315

PPRU:

FDP22_07225 FDP22_17495

PAED:

G5B38_00855 G5B38_01410 G5B38_03515 G5B38_03530 G5B38_08335 G5B38_08835 G5B38_12785

MON:	G8E03_14350

PAMO:

BAR1_13035 BAR1_14675

POZ:	I0K15_02065 I0K15_05420

PALW:

PSAL_009130(abo_1) PSAL_018780(abo_2)

PSHQ:

F3W81_04160 F3W81_20390

PPAF:

I8N54_09580 I8N54_15200

PGV:	SL003B_2784

CACT:

HZ995_04745 HZ995_05725 HZ995_06915 HZ995_07390 HZ995_10220 HZ995_10555 HZ995_15380

THAS:

C6Y53_03320 C6Y53_08730 C6Y53_16540

HDH:	G5B40_00965 G5B40_01990 G5B40_17880

CMAG:

CBW24_01220

GCE:	KYE46_08385 KYE46_11150 KYE46_13420 KYE46_15840 KYE46_17050

NSM:	JO391_07230 JO391_08970 JO391_15875

ACRO:

K3J57_02380 K3J57_13150

SINR:

O5O51_12150

AALK:

LGT41_0002835 LGT41_0002980 LGT41_0006600 LGT41_0011770

AMYL:

QBD29_02625 QBD29_05035 QBD29_06815 QBD29_07555 QBD29_09020 QBD29_15455 QBD29_15880

AMAQ:

GO499_13745 GO499_19135

RHOC:

QTA57_01540 QTA57_12440 QTA57_14800 QTA57_17780

PBAE:

P8S53_13210

LVR:	T8T21_09175

FAQ:	G5B39_05390 G5B39_14330 G5B39_16070

RBX:	I3V23_02345 I3V23_07030

SWI:

Swit_0939

SPHD:

HY78_21825

SMIC:

SmB9_18450

ANH:	A6F65_00140(mlr_2)

HTQ:	FRZ44_31630 FRZ44_34370 FRZ44_36700

HADH:

FRZ61_16050 FRZ61_33550

NACI:

NUH88_07300 NUH88_15070

THAR:

T8K17_10120 T8K17_13700

PUB:	SAR11_1253

PEG:	E5R92_06935

APM:	HIMB5_00008670 HIMB5_00008920

APB:	SAR116_0544 SAR116_1059 SAR116_1184 SAR116_2173

SNEA:

NBZ79_06220 NBZ79_06330 NBZ79_08355 NBZ79_08560

DWD:	DSCW_61450

DALK:

DSCA_57620

ORN:	DV701_04675

» show all

Reference

1 [PMID:13895406]

Authors

FRISELL WR, MACKENZIE CG.

Title

Separation and purification of sarcosine dehydrogenase and dimethylglycine dehydrogenase.

Journal

J Biol Chem 237:94-8 (1962)

Reference

2 [PMID:13716069]

Authors

HOSKINS DD, MACKENZIE CG.

Title

Solubilization and electron transfer flavoprtein requirement of mitochondrial sarcosine dehydrogenase and dimethylglycine dehydrogenase.

Journal

J Biol Chem 236:177-83 (1961)

Reference

3 [PMID:6163777]

Authors

Wittwer AJ, Wagner C

Title

Identification of the folate-binding proteins of rat liver mitochondria as dimethylglycine dehydrogenase and sarcosine dehydrogenase. Purification and folate-binding characteristics.

Journal

J Biol Chem 256:4102-8 (1981)

Reference

4 [PMID:6163778]

Authors

Wittwer AJ, Wagner C

Title

Identification of the folate-binding proteins of rat liver mitochondria as dimethylglycine dehydrogenase and sarcosine dehydrogenase. Flavoprotein nature and enzymatic properties of the purified proteins.

Journal

J Biol Chem 256:4109-15 (1981)

Reference

5 [PMID:2417560]

Authors

Porter DH, Cook RJ, Wagner C

Title

Enzymatic properties of dimethylglycine dehydrogenase and sarcosine dehydrogenase from rat liver.

Journal

Arch Biochem Biophys 243:396-407 (1985)
DOI:10.1016/0003-9861(85)90516-8

Reference

6 [PMID:15358367]

Authors

Brizio C, Brandsch R, Bufano D, Pochini L, Indiveri C, Barile M

Title

Over-expression in Escherichia coli, functional characterization and refolding of rat dimethylglycine dehydrogenase.

Journal

Protein Expr Purif 37:434-42 (2004)
DOI:10.1016/j.pep.2004.06.011

Sequence

[rno:245961]

Reference

7 [PMID:18423846]

Authors

Brizio C, Brandsch R, Douka M, Wait R, Barile M

Title

The purified recombinant precursor of rat mitochondrial dimethylglycine dehydrogenase binds FAD via an autocatalytic reaction.

Journal

Int J Biol Macromol 42:455-62 (2008)
DOI:10.1016/j.ijbiomac.2008.03.001

Sequence

[rno:245961]

Reference

8 [PMID:24858690]

Authors

Luka Z, Pakhomova S, Loukachevitch LV, Newcomer ME, Wagner C

Title

Folate in demethylation: the crystal structure of the rat dimethylglycine dehydrogenase complexed with tetrahydrofolate.

Journal

Biochem Biophys Res Commun 449:392-8 (2014)
DOI:10.1016/j.bbrc.2014.05.064

Sequence

[rno:245961]

Reference

9 [PMID:27486859]

Authors

Augustin P, Hromic A, Pavkov-Keller T, Gruber K, Macheroux P

Title

Structure and biochemical properties of recombinant human dimethylglycine dehydrogenase and comparison to the disease-related H109R variant.

Journal

FEBS J 283:3587-3603 (2016)
DOI:10.1111/febs.13828

Sequence

[hsa:29958]

Other DBs

ExplorEnz - The Enzyme Database:

1.5.8.4

IUBMB Enzyme Nomenclature:

1.5.8.4

ExPASy - ENZYME nomenclature database:

1.5.8.4

BRENDA, the Enzyme Database:

1.5.8.4

CAS:	37256-30-7

DBGET integrated database retrieval system