KEGG ENZYME: 1.5.98.1

ENZYME: 1.5.98.1

Entry

EC 1.5.98.1                 Enzyme

Name

methylenetetrahydromethanopterin dehydrogenase;
N5,N10-methylenetetrahydromethanopterin dehydrogenase;
5,10-methylenetetrahydromethanopterin dehydrogenase

Class

Oxidoreductases;
Acting on the CH-NH group of donors;
With other, known, physiological acceptors

Sysname

5,10-methylenetetrahydromethanopterin:coenzyme-F420 oxidoreductase

Reaction(IUBMB)

5,10-methylenetetrahydromethanopterin + oxidized coenzyme F420 = 5,10-methenyltetrahydromethanopterin + reduced coenzyme F420 [RN:R04456]

Reaction(KEGG)

R04456

Substrate

5,10-methylenetetrahydromethanopterin [CPD:C04377];
oxidized coenzyme F420 [CPD:C00876]

Product

5,10-methenyltetrahydromethanopterin [CPD:C04330];
reduced coenzyme F420 [CPD:C01080]

Comment

Coenzyme F420 is a 7,8-didemethyl-8-hydroxy-5-deazariboflavin derivative; methanopterin is a pterin analogue. The enzyme is involved in the formation of methane from CO2 in the methanogen Methanothermobacter thermautotrophicus.

History

EC 1.5.98.1 created 1989 as EC 1.5.99.9, modified 2004, transferred to EC 1.5.98.1 2014

Pathway

ec00680

Methane metabolism

ec01100

Metabolic pathways

ec01120

Microbial metabolism in diverse environments

Orthology

K00319

methylenetetrahydromethanopterin dehydrogenase

Genes

MJA:

MJ_1035

MFE:	Mefer_1257

MVU:	Metvu_0302

MFS:	MFS40622_1652

MIF:	Metin_0918

MJH:	JH146_0907

MESG:

MLAUSG7_1174(mtd)

MESA:

MLASG1_0617(mtd)

MMP:	MMP0372(mtd)

MMQ:	MmarC5_1303

MMX:	MmarC6_0579

MMZ:	MmarC7_1368

MMD:

GYY_01920

MMAK:

MMKA1_03910(mtd)

MMAO:

MMOS7_03850(mtd)

MMAD:

MMJJ_07050

MAE:

Maeo_1367

MVN:	Mevan_1360

MVO:

Mvol_1675

MOK:	Metok_0668

METF:

CFE53_05635

MTH:

MTH_1464

MMG:	MTBMA_c00500(mtd)

MWO:	MWSIV6_0005(mtd)

MTEE:

MTTB_00390

METC:

MTCT_1331

METE:

tca_01413

METZ:

METMT2_1375

METK:

FVF72_04285

MTHM:

FZP57_09025

METJ:

FZP68_01710

MST:	Msp_0163(mtd)

METB:

AW729_06295

MEIS:

PXD04_04700

MRU:	mru_2142(mtd)

MSI:

Msm_1204

MEB:	Abm4_0039(mtd)

MMIL:

sm9_0086(mtd1) sm9_1352(mtd2)

MEYE:

TL18_10280

MOL:

YLM1_1676

MARO:

MarbSA_11530

METV:

K4897_05370

MEL:	Metbo_0080

MEW:	MSWAN_0008

METH:

MBMB1_0003(mtd)

MFC:	BRM9_0042(mtd)

MFI:	DSM1535_1363(mtd)

MCUB:

MCBB_0002(mtd)

MSUB:

BK009_09725

METN:

BK008_05395

METT:

CIT01_05640

METO:

CIT02_07115

MEME:

HYG87_06515

MFEG:

GCM10025860_07640

MFV:

Mfer_0811

MKA:	MK0011(mtd)

AFU:

AF_0714

AFG:	AFULGI_00007960

APO:	Arcpr_1586

AVE:	Arcve_1338

AST:	Asulf_02280

FPL:

Ferp_1018

GAC:

GACE_0596

GAH:

GAH_01690

MBA:	Mbar_A1095

MBY:	MSBRM_3350

MBW:	MSBRW_3627

MBAR:

MSBR2_3303

MBAK:

MSBR3_3304

MAC:	MA_4430(mtd)

MMA:

MM_1108

MMAZ:

MmTuc01_1147

MMJ:	MSMAS_0195

MMAC:

MSMAC_0200

MVC:	MSVAZ_0176

MEK:	MSKOL_0171

MLS:	MSLAZ_2924

METM:

MSMTP_0225

MEF:	MSWH1_0494

MEQ:	MSWHS_0504

MSJ:	MSSAC_4111

MSZ:	MSSIH_3647

MSW:	MSSIT_3702

MTHR:

MSTHT_1723

MTHE:

MSTHC_1565

MHOR:

MSHOH_0247

MFZ:	AOB57_007795

MBU:	Mbur_0929(mtd)

MMET:

MCMEM_1436

MELO:

J7W08_05895

MMH:

Mmah_0679

MHAZ:

BHR79_10205

MPOT:

BKM01_09905

MEV:	Metev_1727

MZH:	Mzhil_0239

MPY:

Mpsy_1459

MZI:	HWN40_01520

MMAV:

RE476_08770

MSEB:

RE474_05330

MHZ:	Metho_0243

MTP:

Mthe_0809

MCJ:	MCON_1052(mtd)

MHI:

Mhar_1470

MHU:

Mhun_2255

MRTJ:

KHC33_15685

MLA:

Mlab_0079

MEM:	Memar_0562

MBG:	BN140_1676(mtd)

MEMA:

MMAB1_2159(mtd)

MCHK:

MchiMG62_06880

MSUM:

OH143_09530

MRC:	R6Y96_09835

MPI:

Mpet_2185

MEND:

L6E24_10145

MEFW:

F1737_01875

MAQE:

RJ40_06365

MFK:	E2N92_06500

MOU:	OU421_03220

MESB:

L1S32_06805

MANQ:

L1994_02955

MBN:

Mboo_0530

MFO:	Metfor_2657

MPL:

Mpal_0329

MPD:	MCP_1313(mtd)

MEZ:	Mtc_1592(mtd)

RCI:	RCIX2230(mtd)

MEAM:

MU439_04045

MEAE:

QEN48_06140

» show all

Reference

1 [PMID:4084309]

Authors

Hartzell PL, Zvilius G, Escalante-Semerena JC, Donnelly MI.

Title

Coenzyme F420 dependence of the methylenetetrahydromethanopterin dehydrogenase of Methanobacterium thermoautotrophicum.

Journal

Biochem Biophys Res Commun 133:884-90 (1985)
DOI:10.1016/0006-291X(85)91218-5

Reference

2 [PMID:1911853]

Authors

te Brommelstroet BW, Geerts WJ, Keltjens JT, van der Drift C, Vogels GD

Title

Purification and properties of 5,10-methylenetetrahydromethanopterin dehydrogenase and 5,10-methylenetetrahydromethanopterin reductase, two coenzyme F420-dependent enzymes, from Methanosarcina barkeri.

Journal

Biochim Biophys Acta 1079:293-302 (1991)
DOI:10.1016/0167-4838(91)90072-8

Other DBs

ExplorEnz - The Enzyme Database:

1.5.98.1

IUBMB Enzyme Nomenclature:

1.5.98.1

ExPASy - ENZYME nomenclature database:

1.5.98.1

BRENDA, the Enzyme Database:

1.5.98.1

CAS:	100357-01-5

DBGET integrated database retrieval system