KEGG ENZYME: 1.5.99.15

ENZYME: 1.5.99.15

Entry

EC 1.5.99.15                Enzyme

Name

dihydromethanopterin reductase (acceptor);
DmrX

Class

Oxidoreductases;
Acting on the CH-NH group of donors;
With unknown physiological acceptors

Sysname

5,6,7,8-tetrahydromethanopterin:acceptor 5,6-oxidoreductase

Reaction(IUBMB)

5,6,7,8-tetrahydromethanopterin + oxidized acceptor = 7,8-dihydromethanopterin + reduced acceptor [RN:R10802]

Reaction(KEGG)

R10802

Substrate

5,6,7,8-tetrahydromethanopterin [CPD:C01217];
oxidized acceptor

Product

7,8-dihydromethanopterin [CPD:C05927];
reduced acceptor [CPD:C00030]

Comment

This archaeal enzyme catalyses the last step in the biosynthesis of tetrahydromethanopterin, a folate analogue used in methanogenesis. The enzyme, characterized from the archaea Methanosarcina mazei and Methanocaldococcus jannaschii, is an iron-sulfur flavoprotein. cf. EC 1.5.1.47, dihydromethanopterin reductase [NAD(P)+].

History

EC 1.5.99.15 created 2014

Pathway

ec00790

Folate biosynthesis

Orthology

K18853

dihydromethanopterin reductase (acceptor)

Genes

MMT:	Metme_1237

MDN:	JT25_000420

MDH:	AYM39_08130

MKO:	MKLM6_1700

METL:

U737_09955

MPAD:

KEF85_13940

MELL:

IVG45_13805

MRP:	NM686_004240

MMOT:

QZJ86_12525

MAH:	MEALZ_1628

MBUR:

EQU24_12275

MPSY:

CEK71_07200

MEIN:

methR_P0790

MEJ:

Q7A_317

MEC:

Q7C_1997

MPIN:

LGT42_001330

BLEP:

AL038_02455

TSY:	THSYN_32925

SEDS:

AAY24_01730

COX:	E0W60_31950

BYI:	BYI23_B014400

BUE:	BRPE67_BCDS01380

BPH:

Bphy_5942

BCAI:

K788_0001560

PHS:	C2L64_21795 C2L64_38260

PTER:

C2L65_26200

PSAA:

QEN71_34065

VAP:	Vapar_3076

VPD:	VAPA_1c31400

MPT:

Mpe_A2615

METP:

C1M51_15065

RGE:

RGE_40310

LCH:

Lcho_3144

AON:	DEH84_18975

MFA:

Mfla_1582

MMB:

Mmol_0896

MEH:

M301_0950

MEI:	Msip34_1685

MEP:

MPQ_1685

MBAC:

BN1209_0839

MEU:	ACJ67_07090

MPAU:

ZMTM_14840

SPLB:

SFPGR_25830

AZA:	AZKH_p0267

AZD:	CDA09_11345

THU:	AC731_004865

THAU:

C4PIVTH_3702

THK:	CCZ27_13230

MCI:	Mesci_4268

MCIC:

A4R28_05715

MESW:

A9K65_023660

MESM:

EJ066_29785

MOH:	IHQ72_13835

MMEI:

LRP31_13955

PHT:	BLM14_23830

RGA:	RGR602_PC01576

NPM:	QEO92_19260

XAU:

Xaut_4101

XDI:	EZH22_22940

STAR:

G3545_09705

LNE:	FZC33_09375

SNO:

Snov_0764

ANC:	GBB76_00815

APRA:

G3A50_16560

APOL:

K9D25_20120

FIL:	BN1229_v1_0578

FIY:	BN1229_v1_0580

MSC:

BN69_1046

MBRY:

B1812_10070

MROS:

EHO51_11415

MHEY:

H2LOC_018400

MPAR:

F7D14_11875

MIWA:

SS37A_10570

MTW:	CQW49_15585

MECQ:

MSC49_01080

HDI:

HDIA_2296

GBE:	GbCGDNIH1_0764

GBH:	GbCGDNIH2_0764

GBC:	GbCGDNIH3_0764

GBS:	GbCGDNIH4_0764

ALI:	AZOLI_p10902

AOZ:	HUE56_08975

AZS:	E6C72_18300

FWA:	DCMF_03865

AMO:	Anamo_1804

MJA:

MJ_0208

MFE:	Mefer_0472

MVU:	Metvu_1597

MFS:	MFS40622_0016

MJH:	JH146_1595

MESG:

MLAUSG7_0445(dmrX)

MESA:

MLASG1_0063(dmrX)

MIG:	Metig_0591

MTH:

MTH_1379

MMG:	MTBMA_c17660

MWO:	MWSIV6_1760(dmrX)

MTEE:

MTTB_15510

METC:

MTCT_1253

METE:

tca_01333

METZ:

METMT2_0031

METK:

FVF72_04685

MTHM:

FZP57_08615

METJ:

FZP68_02110

MST:

Msp_1473

METB:

AW729_08040

MEIS:

PXD04_03120

MRU:	mru_0123(afpA)

MSI:

Msm_1338

MEB:	Abm4_1689(afpA)

MMIL:

sm9_2248(afpA)

MEYE:

TL18_00390

MOL:

YLM1_1552

MARO:

MarbSA_12740

METV:

K4897_04635

MEL:	Metbo_0161

MEW:	MSWAN_2323

METH:

MBMB1_1960

MFC:	BRM9_2301(afpA3)

MFI:	DSM1535_1235

MCUB:

MCBB_2245(dmrX)

MSUB:

BK009_09065

METN:

BK008_04685

METT:

CIT01_05265

METO:

CIT02_07725

MEME:

HYG87_06115

MFEG:

GCM10025860_06190

MFV:

Mfer_0803

MKA:

MK1484

TSI:

TSIB_0734

TBA:	TERMP_00681

TLT:

OCC_04872

THS:

TES1_0923

THV:	ADU37_CDS11180

PPAC:

PAP_04215

MBA:	Mbar_A1610

MBY:	MSBRM_2843

MBW:	MSBRW_3121

MBAR:

MSBR2_2801

MBAK:

MSBR3_1897

MAC:

MA_0696

MMA:

MM_1854

MMAZ:

MmTuc01_1929

MMJ:	MSMAS_2830

MMAC:

MSMAC_1600

MVC:	MSVAZ_2783

MEK:	MSKOL_2775

MLS:	MSLAZ_0417

METM:

MSMTP_2728

MEF:	MSWH1_0446

MEQ:	MSWHS_0457

MSJ:	MSSAC_0632

MSZ:	MSSIH_0583

MSW:	MSSIT_0615

MTHR:

MSTHT_2252

MTHE:

MSTHC_1028

MHOR:

MSHOH_3527

MFZ:	AOB57_004565

MZI:	HWN40_03795

MMAV:

RE476_06440

MSEB:

RE474_02085

MTP:

Mthe_1166

MHI:

Mhar_0340

MPD:

MCP_1352

MEZ:

Mtc_1049

RCI:

RRC38

MEAM:

MU439_06155

MEAE:

QEN48_03990

SHC:	Shell_1373

IHO:

Igni_0932

IIS:

EYM_03085

DKA:

DKAM_0424

DFD:	Desfe_0335

DMU:	Desmu_0823

TAG:

Tagg_0595

IAG:

Igag_0279

THG:	TCELL_0838

PFM:	Pyrfu_0994

PSYT:

DSAG12_01802

» show all

Reference

1 [PMID:23995635]

Authors

Wang S, Tiongson J, Rasche ME

Title

Discovery and characterization of the first archaeal dihydromethanopterin reductase, an iron-sulfur flavoprotein from Methanosarcina mazei.

Journal

J Bacteriol 196:203-9 (2014)
DOI:10.1128/JB.00457-13

Sequence

[mma:MM_1854]

Other DBs

ExplorEnz - The Enzyme Database:

1.5.99.15

IUBMB Enzyme Nomenclature:

1.5.99.15

ExPASy - ENZYME nomenclature database:

1.5.99.15

BRENDA, the Enzyme Database:

1.5.99.15

DBGET integrated database retrieval system