Entry Name NAD(P)H oxidase (H2O-forming)
Class Oxidoreductases;BRITE hierarchy
Sysname NAD(P)H:oxygen oxidoreductase (H2O-forming)
Reaction(IUBMB) 2 NAD(P)H + 2 H+ + O2 = 2 NAD(P)+ + 2 H2O [RN:
R10517 R10518 ]
Reaction(KEGG) Substrate Product Comment A flavoprotein (FAD). NADPH is a better substrate than NADH [1,3]. By removal of oxygen the enzyme is involved in aerobic tolerance in the thermophilic anaerobic archaeon Thermococcus profundus and in Giardia intestinalis, a microaerophilic single-celled parasite of the order Diplomonadida.
History EC 1.6.3.2 created 2013
Reference Authors Brown DM, Upcroft JA, Upcroft P
Title A H2O-producing NADH oxidase from the protozoan parasite Giardia duodenalis.
Journal Reference Authors Li L, Wang CC
Title A likely molecular basis of the susceptibility of Giardia lamblia towards oxygen.
Journal Reference Authors Jia B, Park SC, Lee S, Pham BP, Yu R, Le TL, Han SW, Yang JK, Choi MS, Baumeister W, Cheong GW
Title Hexameric ring structure of a thermophilic archaeon NADH oxidase that produces predominantly H2O.
Journal Reference Authors Jia B, Lee S, Pham BP, Cho YS, Yang JK, Byeon HS, Kim JC, Cheong GW
Title An archaeal NADH oxidase causes damage to both proteins and nucleic acids under oxidative stress.
Journal Other DBs ExplorEnz - The Enzyme Database: 1.6.3.2
ExPASy - ENZYME nomenclature database: 1.6.3.2
BRENDA, the Enzyme Database: 1.6.3.2
