KEGG ENZYME: 1.6.5.12

ENZYME: 1.6.5.12

Entry

EC 1.6.5.12                 Enzyme

Name

demethylphylloquinone reductase;
ndbB (gene name);
NDC1 (gene name);
demethylphylloquinone:NADPH oxidoreductase

Class

Oxidoreductases;
Acting on NADH or NADPH;
With a quinone or similar compound as acceptor

Sysname

NADPH:demethylphylloquinone oxidoreductase

Reaction(IUBMB)

demethylphylloquinone + NADPH + H+ = demethylphylloquinol + NADP+ [RN:R11061]

Reaction(KEGG)

R11061

Substrate

demethylphylloquinone [CPD:C13309];
NADPH [CPD:C00005];
H+ [CPD:C00080]

Product

demethylphylloquinol [CPD:C21084];
NADP+ [CPD:C00006]

Comment

The enzyme, found in plants and cyanobacteria, is involved in the biosynthesis of phylloquinone (vitamin K1), an electron carrier associated with photosystem I. The enzyme is a type II NADPH dehydrogenase and requires a flavine adenine dinucleotide cofactor.

History

EC 1.6.5.12 created 2015

Pathway

ec00130

Ubiquinone and other terpenoid-quinone biosynthesis

ec01100

Metabolic pathways

ec01110

Biosynthesis of secondary metabolites

Orthology

K17872

demethylphylloquinone reductase

Genes

ATH:	AT5G08740(NDC1)

ALY:

9309449

CRB:

17882848

CSAT:

104708204 104734909 104769096

EUS:	EUTSA_v10013258mg

BRP:

103847188

BNA:	106419271 111212609

BOE:

106319430

RSZ:

108817949

THJ:

104819353

CPAP:

110816571

CIT:

102618551

CIC:	CICLE_v10000807mg

PVY:	116105075 116106474

MINC:

123199089

TCC:

18611964

GRA:

105762580

GHI:	107930822 107931253

GAB:

108476577

HSYR:

120144484 120147677

DZI:

111316878

EGR:

104415973

GMX:

100795521

GSJ:

114413256

PVU:	PHAVU_002G275600g

VRA:

106769327

VAR:

108323929

VUN:

114174969

VUM:

124834409

CCAJ:

109789425

APRC:

113854729

MTR:

11437509

TPRA:

123916097

CAM:

101503757

PSAT:

127104529

VVO:	131602889 131602909

LJA:	Lj4g3v2827910.1(Lj4g3v2827910.1) Lj4g3v2827910.2(Lj4g3v2827910.2)

ADU:

107480195

AIP:

107630920

AHF:	112733033 112791068

LANG:

109358669

PCIN:

129307686

QSA:	O6P43_030251

FVE:

101308875

RCN:

112176025

PPER:

18777173

PMUM:

103337243

PAVI:

110753675

PDUL:

117628767

MDM:

103433086

MSYL:

126617742

PXB:

103952273

ZJU:

107425337

MNT:

21407825

CSAV:

115714294

CSV:

101223053

CMO:

103486095

BHJ:

120073875

MCHA:

111017844

CMAX:

111465980

CMOS:

111432564

CPEP:

111782254

RCU:

8282114

JCU:

105639437

HBR:	110657024 110660355

MESC:

110624194

POP:

7490188

PEU:

105124511

PALZ:

118043455

JRE:

108996371

CILL:

122303325

CAVE:

132165495

QSU:

112019031

QLO:

115964007

TWL:

119990388

VVI:

100264660

VRI:

117918827

SLY:

101263978

SPEN:

107015022

SOT:

102581506

SSTN:

125859518

SDUL:

129894231

CANN:

107868106

LBB:

132617261

NTA:	107796444 107800648

NSY:

104238606

NTO:

104085114

NAU:

109225159

INI:

109179495

ITR:

116012717

SIND:

105176066

OEU:	111365483 111409157

EGT:	105959868 105964861

SSPL:

121779817 121782608

SMIL:

131008639

SHIS:

125213312

APAN:

127257388

HAN:

110873719

ECAD:

122581717

LSV:

111879295

CCAV:

112519684

DCR:

108219442

CSIN:

114307524

RVL:

131315804

AEW:

130785265

BVG:

104890540

SOE:

110800407

CQI:	110701317 110736653

ATRI:

130828174

MOF:

131160634

NNU:

104587537

MING:

122063951 122069453 122081702

TSS:	122666642 122668851

PSOM:

113346448 113356398

OSA:

4340478

DOSA:

Os06t0214900-01(Os06g0214900)

OBR:

102715487

OGL:

127776414

BDI:

100823745

ATS:

109746764

TDC:	119328641 119341753

TAES:

123148304 123161869 123164500

TUA:

125525340

LPER:

127317730

LRD:

124685253

SBI:

8080027

ZMA:

100282489

SITA:

101767448

SVS:

117852339

PVIR:

120669531 120703183

PHAI:

112889324

PDA:

103723780

EGU:

105034423

MUS:

103986928

ZOF:	122008689 122016738

DCT:

110115656

PEQ:

110035971

AOF:

109832866

MSIN:

131242549

NCOL:

116259399

ATR:

18429029

SMO:	SELMODRAFT_178273 SELMODRAFT_268023

PPP:

112277043

CRE:	CHLRE_16g671000v5

VCN:	VOLCADRAFT_107672

MNG:

MNEG_6066

CSL:	COCSUDRAFT_12331

APRO:

F751_3208

OLU:	OSTLU_36839

OTA:	OT_ostta04g03900

BPG:	Bathy08g03260

MIS:	MICPUN_60345

MPP:	MICPUCDRAFT_47596(JGI:MicpuC2_47596)

CME:	CYME_CMM178C

GSL:	Gasu_20690

CCP:	CHC_T00004265001

EHX:	EMIHUDRAFT_461368 EMIHUDRAFT_470045

PMAW:

MACH26_20330(yjlD)

SYN:	slr1743(ndh)

SYZ:	MYO_112180(ndh)

SYY:	SYNGTS_1207(ndh)

SYT:	SYNGTI_1207(ndh)

SYS:	SYNPCCN_1206(ndh)

SYQ:	SYNPCCP_1206(ndh)

SYJ:	D082_23110(ndbB)

SYO:	C7I86_06260

SYC:	syc1598_c(ndbB)

SYU:	M744_03695

SYF:	Synpcc7942_2508

SYD:	Syncc9605_2310

SYE:	Syncc9902_0383

SYG:

sync_2511

SYR:	SynRCC307_0389(ndh)

SYX:	SynWH7803_2175(ndh)

CYA:

CYA_0862

CYB:

CYB_1748

SYNE:

Syn6312_3456

SYNP:

Syn7502_00863

SYNK:

KR100_14260

SYNR:

KR49_07070

SYND:

KR52_04635

SYH:	Syncc8109_2392

SYNW:

SynWH8103_02483

SYNC:

CB0101_14370

SYNY:

BM449_09305

DSL:	Dacsa_1246

SYW:

SYNW2165

CGC:	Cyagr_1568

CYI:	CBM981_3061

PMA:	Pro_0096(ndh)

PMM:

PMM0082

PMT:

PMT_1625

PMN:	PMN2A_1446

PMI:	PMT9312_0085

PMB:	A9601_00951

PMC:	P9515_00921

PMF:	P9303_02581

PMG:	P9301_00941

PMH:	P9215_00951

PMJ:	P9211_00911

PME:	NATL1_01471

PRC:

EW14_0102

PRM:

EW15_0164

WNA:	KA717_28445

CMP:	Cha6605_4090

CYN:	Cyan7425_1446

CEP:	Cri9333_2861

TVN:	NIES2134_101430(ndbB)

SLW:	BRW62_03875

AMR:

AM1_2697

ACAM:

HRE53_10465

TEL:	tlr1136(ndbB)

THN:	NK55_02985(ndbB)

THEC:

FFX45_12480

TSZ:	OOK60_00830

LEN:	LEP3755_58200

LET:	O77CONTIG1_02936(ndh)

LBO:	LBWT_15670

KOV:	K9N68_15810

LSC:	KIK02_04980

LSK:	J5X98_03075

HHG:	XM38_046090

PSEU:

Pse7367_2005

PSER:

ABRG53_2102

PGX:	OA858_09790

THEU:

HPC62_17325

TOG:	HNI00_21205

TSIN:

OXH18_01100

GLP:	Glo7428_4351

CHON:

NIES4102_17540

GDU:	P0S91_11105

GEN:	GM3709_2091

GEE:	GM3708_3185

CAN:	Cyan10605_3058

CSN:	Cyast_0025

CYL:	AA637_13705(ndh-2)

SYP:	SYNPCC7002_A2120(ndbB)

SYV:	AWQ23_10615

SYL:	AWQ21_10770

LEP:	Lepto7376_3344

SYNN:

NIES970_15700(ndbB)

MAR:	MAE_42940(ndbB2) MAE_62400(ndbB1)

MPK:	VL20_2143 VL20_2695

MIQ:	B5D77_01060 B5D77_12325

MVZ:	myaer102_17350(ndbB2) myaer102_34460(ndbB1)

HAO:	PCC7418_2212

ENN:	FRE64_05310

CYU:	UCYN_05790

CYT:	cce_0154(ndbB) cce_4052

CWA:	CwatDRAFT_6161

CYP:	PCC8801_0031 PCC8801_0681

CYH:	Cyan8802_0029 Cyan8802_0708

CYC:	PCC7424_3107 PCC7424_4523

CYJ:	Cyan7822_0200 Cyan7822_1479

TER:	Tery_3661 Tery_4096

ARP:	NIES39_C03210(ndbB)

PAGH:

NIES204_19420(ndbB)

PPSU:

NO713_01928(ndbB)

PRUN:

PCC7821_02333(ndbB)

OXY:	HCG48_23500

MVAG:

D0A34_10010

LFS:	HFV01_11460

OAC:	Oscil6304_3986

ONI:	Osc7112_2336

MPRO:

BJP34_02545

PHOR:

JWS08_08025 JWS08_21680

PYH:	NEA10_04525 NEA10_10525

MIC:	Mic7113_3565

GEI:	GEI7407_1584 GEI7407_3314

GVI:

glr3503

GLJ:	GKIL_1185(ndh)

GML:	ISF26_14955

ANA:

alr4094

NPU:	Npun_R1623

NOS:	Nos7107_4485

NOP:	Nos7524_0617

NON:	NOS3756_49290

NFL:	COO91_00248

NOE:	CLI64_02480

NSH:

GXM_05919

NED:	HUN01_32080

NPZ:	ACX27_21560

AVA:

Ava_0810

NAZ:

Aazo_4817

ANB:	ANA_C11689(ndh)

ACY:	Anacy_2011 Anacy_4522

AWA:	AA650_17225

ANN:	EH233_26120

CSG:	Cylst_6117

RSIN:

B6N60_02534

HBQ:	QI031_04880

CALO:

Cal7507_0568

CALT:

Cal6303_0926

CALH:

IJ00_11250

CALN:

NIES2098_10340

CALS:

NIES3974_46320

RIV:	Riv7116_6852

FIS:	FIS3754_01360

NSPH:

BDGGKGIB_01467(ndbB)

DOU:	BMF77_01764(ndh)

DFS:	HGD76_09485

CCUR:

IAR63_12545

CRK:	L3I90_11710

AFLO:

HEQ12_16425

STOQ:

K2F26_06975

AEE:	IM676_10380

RCS:	NIES932_30470

TOQ:	HCG51_22050

ALAX:

NIES50_13870

NCN:	BZZ01_13585

CTHE:

Chro_5076

PLP:	Ple7327_0734 Ple7327_4053

SCS:	Sta7437_2980 Sta7437_3640

STAN:

STA3757_26730 STA3757_30400(ndbB)

GLT:	GlitD10_0470(ndh)

GCY:	LQF76_14055

CEO:	ETSB_0596(ndbB)

CER:	RGRSB_0558(ndbB)

CEEC:

P3F56_02900

CTM:	Cabther_B0793

CVL:	J8C06_15040

CHLO:

J8C02_12325

MEAE:

QEN48_05755

» show all

Reference

1 [PMID:26023160]

Authors

Fatihi A, Latimer S, Schmollinger S, Block A, Dussault PH, Vermaas WF, Merchant SS, Basset GJ

Title

A Dedicated Type II NADPH Dehydrogenase Performs the Penultimate Step in the Biosynthesis of Vitamin K1 in Synechocystis and Arabidopsis.

Journal

Plant Cell 27:1730-41 (2015)
DOI:10.1105/tpc.15.00103

Sequence

[ath:AT5G08740] [syn:slr1743]

Other DBs

ExplorEnz - The Enzyme Database:

1.6.5.12

IUBMB Enzyme Nomenclature:

1.6.5.12

ExPASy - ENZYME nomenclature database:

1.6.5.12

BRENDA, the Enzyme Database:

1.6.5.12

DBGET integrated database retrieval system