KEGG ENZYME: 1.7.1.9

ENZYME: 1.7.1.9

Entry

EC 1.7.1.9                  Enzyme

Name

nitroquinoline-N-oxide reductase;
4-nitroquinoline 1-oxide reductase;
4NQO reductase;
NAD(P)H2:4-nitroquinoline-N-oxide oxidoreductase

Class

Oxidoreductases;
Acting on other nitrogenous compounds as donors;
With NAD+ or NADP+ as acceptor

Sysname

4-(hydroxyamino)quinoline N-oxide:NADP+ oxidoreductase

Reaction(IUBMB)

4-(hydroxyamino)quinoline N-oxide + 2 NAD(P)+ + H2O = 4-nitroquinoline N-oxide + 2 NAD(P)H + 2 H+ [RN:R04228 R04229]

Reaction(KEGG)

R04228 R04229

Substrate

4-hydroxyaminoquinoline N-oxide [CPD:C04050];
NAD+ [CPD:C00003];
NADP+ [CPD:C00006];
H2O [CPD:C00001]

Product

4-nitroquinoline N-oxide [CPD:C03474];
NADH [CPD:C00004];
NADPH [CPD:C00005];
H+ [CPD:C00080]

History

EC 1.7.1.9 created 1972 as EC 1.6.6.10, transferred 2002 to EC 1.7.1.9

Reference

Authors

Toriyama, N.

Title

[Metabolism of quinoline derivatives. On the reducing enzyme of 4-nitroquinoline-N-oxide].

Journal

Nichidai Igaku Zasshi 24:423-432 (1965)

Reference

2 [PMID:1370076]

Authors

Stanley JS, York JL, Benson AM.

Title

Nitroreductases and glutathione transferases that act on 4-nitroquinoline 1-oxide and their differential induction by butylated hydroxyanisole in mice.

Journal

Cancer Res 52:58-63 (1992)

Other DBs

ExplorEnz - The Enzyme Database:

1.7.1.9

IUBMB Enzyme Nomenclature:

1.7.1.9

ExPASy - ENZYME nomenclature database:

1.7.1.9

BRENDA, the Enzyme Database:

1.7.1.9

CAS:	37256-35-2

All links

Chemical substance (8)   
   KEGG COMPOUND (8)   
Chemical reaction (3)   
   KEGG REACTION (2)   
   KEGG RCLASS (1)   
Protein sequence (3)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (1)   
DNA sequence (2)   
   RefSeq(nuc) (2)   
Protein domain (3)   
   InterPro (3)   
All databases (19)   

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