KEGG   ENZYME: 1.7.2.6
Entry
EC 1.7.2.6                  Enzyme                                 
Name
hydroxylamine dehydrogenase;
HAO (ambiguous);
hydroxylamine oxidoreductase (ambiguous);
hydroxylamine oxidase (misleading)
Class
Oxidoreductases;
Acting on other nitrogenous compounds as donors;
With a cytochrome as acceptor
Sysname
hydroxylamine:ferricytochrome-c oxidoreductase (nitrite-forming)
Reaction(IUBMB)
hydroxylamine + H2O + 4 ferricytochrome c = nitrite + 4 ferrocytochrome c + 5 H+ [RN:R10164]
Reaction(KEGG)
R10164
Substrate
hydroxylamine [CPD:C00192];
H2O [CPD:C00001];
ferricytochrome c [CPD:C00125]
Product
nitrite [CPD:C00088];
ferrocytochrome c [CPD:C00126];
H+ [CPD:C00080]
Comment
The enzymes from the nitrifying bacterium Nitrosomonas europaea [1,4] and the methylotrophic bacterium Methylococcus capsulatus [5] are hemoproteins with seven c-type hemes and one specialized P-460-type heme per subunit. The enzyme converts hydroxylamine to nitrite via an enzyme-bound nitroxyl intermediate [3]. While nitrite is the main product, the enzyme from Nitrosomonas europaea can also produce nitric oxide by catalysing the activity of EC 1.7.2.9, hydroxylamine oxidase [2].
History
EC 1.7.2.6 created 1972 as EC 1.7.3.4, part transferred 2012 to EC 1.7.2.6, modifed 2021, modified 2021
Pathway
ec00910  Nitrogen metabolism
ec01100  Metabolic pathways
ec01120  Microbial metabolism in diverse environments
Orthology
K10535  hydroxylamine dehydrogenase
Genes
VFL: AL536_13820
PGH: FH974_09640
GHO: AL542_00990
SSE: Ssed_3758 Ssed_4366
SHL: Shal_1091
SWD: Swoo_4755
SKH: STH12_01223(hao1)
SCYP: JYB88_10420
SSEM: JYB85_07405
AGZ: M0C34_15345
AGQ: LQZ07_18345
HALC: EY643_14770
MCA: MCA0956
METU: GNH96_08475
MMEO: OOT43_17560
MRP: NM686_000190
MAH: MEALZ_1830(hao)
MBUR: EQU24_08350
MMAI: sS8_3996
MSZE: MSZNOR_3397(hao)
MMOB: F6R98_20735
MOZ: MoryE10_01020
MEIY: MIN45_P1027
MCAU: MIT9_P2476
NOC: Noc_0892
NHL: Nhal_1085
NWA: Nwat_0758
NWR: E3U44_17775
TVI: Thivi_1285 Thivi_1727
TMB: Thimo_1376
NTT: TAO_0474(haoA)
TTP: E6P07_00340
NTG: NSCAC_1127(hao)
THIP: N838_23495
THIM: KFB96_23910
TBOG: LT988_06870 LT988_19330
TLR: Thiosp_01677(hao1_1)
EPS: L0Y14_05540 L0Y14_06805 L0Y14_09955
MGEO: CFI10_15045
MSEC: LN244_03125
GSN: YC6258_02023
SVA: SVA_2722
THO: SP60_06870
REV: HUE57_17855
RFR: Rfer_0059
COF: FOZ74_14370
NEU: NE0962(hao2) NE2044(hao1) NE2339(hao3)
NET: Neut_1672 Neut_1793 Neut_2335
NIT: NAL212_1807 NAL212_2138 NAL212_2750
NII: Nit79A3_0807 Nit79A3_0822 Nit79A3_2942
NCO: AAW31_01285 AAW31_16290 AAW31_18275
NUR: ATY38_00070 ATY38_06640 ATY38_10080 ATY38_15220
NST: Nstercoris_00693 Nstercoris_01409 Nstercoris_02225
NMU: Nmul_A0805 Nmul_A1082 Nmul_A2662
NLC: EBAPG3_003140 EBAPG3_006260 EBAPG3_012560
NIZ: NNRS527_00826 NNRS527_01109 NNRS527_02973
NIV: JY500_20665
DDZ: DSYM_27790
MSC: BN69_3242
MROS: EHO51_04010
MHEY: H2LOC_009200
MPAR: F7D14_18670
MIWA: SS37A_24720
SIL: SPOA0201
MAGQ: MGMAQ_1797
MGM: Mmc1_0550 Mmc1_3025
HFE: HFELIS_07960
HBI: HBZC1_10550
HCE: HCW_02425
HCM: HCD_03625
HHM: BN341_2930
HSH: NHP194022_13670
HAIL: ASB7_09160
CFF: CFF8240_0800
CFT: CFF04554_0806
CFV: CFVI03293_0949
CFX: CFV97608_0865
CFZ: CSG_11900
CAMP: CFT03427_0792
CFP: CR44_04030
CCV: CCV52592_0434
CCO: CCC13826_1552
CCOC: CCON33237_0583
CAJ: CIG1485E_1075
CGRA: CGRAC_2027
CHYO: CHH_0728
CPIN: CPIN18020_1239
CGEO: CGEO_1057
CBLA: CBLAS_1476
CMUC: CMCT_0574
ANT: Arnit_1867
AMOL: AMOL_1575
HEBR: AEBR_2203
AANA: AANAER_2174
NAM: NAMH_1280
NAP: C3L23_06730
CMED: FE773_03965
CPAF: C6V80_06735
DAV: DESACE_06540
GME: Gmet_0142
GPI: GPICK_00415
GEM: GM21_0983
GEB: GM18_0233 GM18_1834 GM18_2729
GUR: Gura_1628
GLO: Glov_1044
GBM: Gbem_3667
GBN: GEOBRER4_35680
GER: KP004_04185 KP004_20970
GSB: GSUB_01230
DEU: DBW_1324
DVE: DESUT3_15840
DES: DSOUD_1989
DFL: DFE_0004
PSYF: N1030_04880
DSB: LN040_02740
DDE: Dde_0300
DMS: E8L03_02115 E8L03_18435 E8L03_19655
DHY: DESAM_20150
DAF: Desaf_0946 Desaf_1748
DPI: BN4_11252 BN4_12791
DEJ: AWY79_06255 AWY79_08845
PPRF: DPRO_1839 DPRO_2651
PSEL: GM415_07795 GM415_15315
DDN: DND132_1554
PSEF: PSDVSF_14970
PPOR: JCM14722_11600
PNW: SYK_29610
PTHE: LF599_14705
DSX: GD604_02500
PBIZ: LWC08_15290
DBA: Dbac_0217
DRT: Dret_1248 Dret_2383
DSF: UWK_00763 UWK_02292
DBK: DGMP_05910 DGMP_39400
DDU: GF1_22420
DOL: Dole_1634
DAL: Dalk_2369 Dalk_2563 Dalk_3570
DAT: HRM2_00870 HRM2_07570
DTO: TOL2_C02850
DOV: DSCO28_29230 DSCO28_72600
DWD: DSCW_06220 DSCW_34050 DSCW_34270 DSCW_58830
DALK: DSCA_52000 DSCA_52610
DML: Dmul_03220 Dmul_30760
DLI: dnl_39220 dnl_50430
DMM: dnm_030860
DEK: DSLASN_29050
DTI: Desti_4134 Desti_4281
SFU: Sfum_2550
DAX: FDQ92_05200 FDQ92_07200
DBR: Deba_1332 Deba_1630
DMP: FAK_21050
TID: Thein_0424 Thein_2217
TOP: TOPB45_0384 TOPB45_0551
TAV: G4V39_02595 G4V39_10675
TMAI: FVE67_00020 FVE67_02225 FVE67_08170
ADE: Adeh_1764
ACP: A2cp1_0959 A2cp1_2170
AFW: Anae109_0953
ANK: AnaeK_0956 AnaeK_2076
CFUS: CYFUS_008857
MRM: A7982_01893
LLU: AKJ09_07040
DHR: LGS26_01085
DOR: Desor_3789
DAI: Desaci_0102 Desaci_0818
DMI: Desmer_0501
CALK: HUE98_14995
OPR: Ocepr_0853
MIN: Minf_2434(cccA)
MKC: kam1_2135
MFH: MFUM_2472(hao)
MCAO: IT6_06280
LCRE: Pla8534_10350(hao1)
PLH: VT85_05655(hao1)
PVAR: SH412_000825
PBOR: BSF38_05477(hao1)
AGV: OJF2_56510(hao1)
KST: KSMBR1_1764(hao_1) KSMBR1_2163(hao_2) KSMBR1_3397(hao_5) KSMBR1_3422(hao_6) KSMBR1_3442(hao_7) KSMBR1_3792(hao_8)
BROC: IPI25_04955 IPI25_06490 IPI25_07420 IPI25_09825 IPI25_11795 IPI25_13695
BPIT: BPIT_04170 BPIT_07980 BPIT_13210 BPIT_14680 BPIT_19600 BPIT_21190 BPIT_21780
JET: L3J17_01580 L3J17_03290 L3J17_04875 L3J17_06450
PCOR: KS4_29250(hao1)
ALUS: STSP2_00683(hao1)
THYD: TTHT_0107 TTHT_1535
IAL: IALB_0863
MRO: MROS_1112
TAM: Theam_0418
TTK: TST_0960 TST_1228
DDF: DEFDS_1818
DAP: Dacet_1014
FSI: Flexsi_0284
CABY: Cabys_2203 Cabys_2556
DTP: JZK55_10500
NMV: NITMOv2_1281
NIO: NITINOP_0065(hao)
NJA: NSJP_2412
NKF: Nkreftii_001662 Nkreftii_003177
NIF: W02_39400
NTI: DNFV4_01719
MOX: DAMO_2285 DAMO_2473(hao)
FSH: Q2T83_13455 Q2T83_17735
FPL: Ferp_0649 Ferp_0711 Ferp_1198
GAC: GACE_0430 GACE_1826
GAH: GAH_00817 GAH_01297
MBU: Mbur_0467
IHO: Igni_0955
IIS: EYM_05715
PFM: Pyrfu_1339
 » show all
Reference
1  [PMID:5758552]
  Authors
Rees MK.
  Title
Studies of the hydroxylamine metabolism of Nitrosomonas europaea. I. Purification of hydroxylamine oxidase.
  Journal
Biochemistry 7:353-66 (1968)
DOI:10.1021/bi00841a045
Reference
2  [PMID:497235]
  Authors
Hooper AB, Terry KR
  Title
Hydroxylamine oxidoreductase of Nitrosomonas. Production of nitric oxide from hydroxylamine.
  Journal
Biochim Biophys Acta 571:12-20 (1979)
DOI:10.1016/0005-2744(79)90220-1
Reference
3  [PMID:7117545]
  Authors
Hooper AB, Balny C.
  Title
Reaction of oxygen with hydroxylamine oxidoreductase of Nitrosomonas: fast kinetics.
  Journal
FEBS Lett 144:299-303 (1982)
DOI:10.1016/0014-5793(82)80658-3
Reference
4  [PMID:6289867]
  Authors
Lipscomb JD, Hooper AB.
  Title
Resolution of multiple heme centers of hydroxylamine oxidoreductase from Nitrosomonas. 1. Electron paramagnetic resonance spectroscopy.
  Journal
Biochemistry 21:3965-72 (1982)
DOI:10.1021/bi00260a010
Reference
5  [PMID:18650926]
  Authors
Poret-Peterson AT, Graham JE, Gulledge J, Klotz MG
  Title
Transcription of nitrification genes by the methane-oxidizing bacterium, Methylococcus capsulatus strain Bath.
  Journal
ISME J 2:1213-20 (2008)
DOI:10.1038/ismej.2008.71
Other DBs
ExplorEnz - The Enzyme Database: 1.7.2.6
IUBMB Enzyme Nomenclature: 1.7.2.6
ExPASy - ENZYME nomenclature database: 1.7.2.6
BRENDA, the Enzyme Database: 1.7.2.6
CAS: 9075-43-8

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Pathway (8)   
   KEGG PATHWAY (6)   
   KEGG MODULE (2)   
Chemical substance (6)   
   KEGG COMPOUND (6)   
Chemical reaction (2)   
   KEGG REACTION (1)   
   KEGG RCLASS (1)   
Gene (1213)   
   KEGG ORTHOLOGY (1)   
   KEGG GENES (299)   
   KEGG MGENES (859)   
   RefGene (54)   
Protein sequence (261)   
   UniProt (247)   
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DNA sequence (49)   
   GenBank (25)   
   EMBL (24)   
3D Structure (2)   
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