KEGG ENZYME: 1.7.2.7

ENZYME: 1.7.2.7

Entry

EC 1.7.2.7                  Enzyme

Name

hydrazine synthase;
HZS

Class

Oxidoreductases;
Acting on other nitrogenous compounds as donors;
With a cytochrome as acceptor

Sysname

hydrazine:ferricytochrome-c oxidoreductase

Reaction(IUBMB)

hydrazine + H2O + 3 ferricytochrome c = nitric oxide + ammonium + 3 ferrocytochrome c [RN:R09799]

Reaction(KEGG)

R09799

Substrate

hydrazine [CPD:C05361];
H2O [CPD:C00001];
ferricytochrome c [CPD:C00125]

Product

nitric oxide [CPD:C00533];
ammonium;
ferrocytochrome c [CPD:C00126]

Comment

The enzyme, characterized from anaerobic ammonia oxidizers (anammox bacteria), is one of only a few enzymes that are known to form an N-N bond (other examples include EC 1.7.1.14, nitric oxide reductase [NAD(P)+, nitrous oxide-forming] and EC 4.8.1.1, L-piperazate synthase). The enzyme from the bacterium Candidatus Kuenenia stuttgartiensis is a dimer of heterotrimers and contains multiple c-type cytochromes.

History

EC 1.7.2.7 created 2016, modified 2021

Pathway

ec00910

Nitrogen metabolism

ec01100

Metabolic pathways

ec01120

Microbial metabolism in diverse environments

Orthology

K20932

hydrazine synthase subunit

K20933

hydrazine synthase subunit

K20934

hydrazine synthase subunit

Genes

KST:	KSMBR1_2703(hzsC_3) KSMBR1_2704(hzsB_3) KSMBR1_2711(hzsC_1) KSMBR1_2712(hzsB_1) KSMBR1_2713(hzsA_1) KSMBR1_3601(hzsC_2) KSMBR1_3602(hzsB_2) KSMBR1_3603(hzsA_2)

BROC:

IPI25_02780 IPI25_02805 IPI25_02810 IPI25_10105 IPI25_10120

BPIT:

BPIT_07240 BPIT_07250 BPIT_07260 BPIT_07540 BPIT_26620 BPIT_26630 BPIT_26640

JET:	L3J17_02470 L3J17_02475 L3J17_02480 L3J17_08105 L3J17_08110 L3J17_09005

Reference

1 [PMID:21964329]

Authors

Kartal B, Maalcke WJ, de Almeida NM, Cirpus I, Gloerich J, Geerts W, Op den Camp HJ, Harhangi HR, Janssen-Megens EM, Francoijs KJ, Stunnenberg HG, Keltjens JT, Jetten MS, Strous M

Title

Molecular mechanism of anaerobic ammonium oxidation.

Journal

Nature 479:127-30 (2011)
DOI:10.1038/nature10453

Sequence

[ag:CAJ73611 CAJ73612 CAJ73613]

Reference

2 [PMID:26479033]

Authors

Dietl A, Ferousi C, Maalcke WJ, Menzel A, de Vries S, Keltjens JT, Jetten MS, Kartal B, Barends TR.

Title

The inner workings of the hydrazine synthase multiprotein complex.