KEGG ENZYME: 1.7.2.8

ENZYME: 1.7.2.8

Entry

EC 1.7.2.8                  Enzyme

Name

hydrazine dehydrogenase;
HDH

Class

Oxidoreductases;
Acting on other nitrogenous compounds as donors;
With a cytochrome as acceptor

Sysname

hydrazine:ferricytochrome c oxidoreductase

Reaction(IUBMB)

hydrazine + 4 ferricytochrome c = N2 + 4 ferrocytochrome c [RN:R07174]

Reaction(KEGG)

R07174

Substrate

hydrazine [CPD:C05361];
ferricytochrome c [CPD:C00125]

Product

N2 [CPD:C00697];
ferrocytochrome c [CPD:C00126]

Comment

The enzyme, which is involved in the pathway of anaerobic ammonium oxidation in anammox bacteria, has been purified from the bacterium Candidatus Kuenenia stuttgartiensis. The electrons derived from hydrazine are eventually transferred to the quinone pool.

History

EC 1.7.2.8 created 2003 as EC 1.7.99.8, modified 2010, transferred 2016 to EC 1.7.2.8

Pathway

ec00910

Nitrogen metabolism

ec01100

Metabolic pathways

ec01120

Microbial metabolism in diverse environments

Orthology

K20935

hydrazine dehydrogenase

Genes

KST:	KSMBR1_1220(hdh) KSMBR1_2369(hdh)

BROC:

IPI25_10085

BPIT:

BPIT_07300 BPIT_13410

JET:	L3J17_08080 L3J17_11210

Reference

1 [PMID:10820012]

Authors

Schalk J, de Vries S, Kuenen JG, Jetten MS.

Title

Involvement of a novel hydroxylamine oxidoreductase in anaerobic ammonium oxidation.

Journal

Biochemistry 39:5405-12 (2000)
DOI:10.1021/bi992721k

Reference

2 [PMID:11404106]

Authors

Jetten MS, Wagner M, Fuerst J, van Loosdrecht M, Kuenen G, Strous M.

Title

Microbiology and application of the anaerobic ammonium oxidation ('anammox') process.

Journal

Curr Opin Biotechnol 12:283-8 (2001)
DOI:10.1016/S0958-1669(00)00211-1

Reference

3 [PMID:21964329]

Authors

Kartal B, Maalcke WJ, de Almeida NM, Cirpus I, Gloerich J, Geerts W, Op den Camp HJ, Harhangi HR, Janssen-Megens EM, Francoijs KJ, Stunnenberg HG, Keltjens JT, Jetten MS, Strous M

Title

Molecular mechanism of anaerobic ammonium oxidation.

Journal

Nature 479:127-30 (2011)
DOI:10.1038/nature10453

Sequence

[ag:CAJ71439]

Reference

4 [PMID:23210799]

Authors

Kartal B, de Almeida NM, Maalcke WJ, Op den Camp HJ, Jetten MS, Keltjens JT

Title

How to make a living from anaerobic ammonium oxidation.